GREMLIN Database
DUF3014 - Protein of unknown function (DUF3014)
PFAM: PF11219 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 156 (156)
Sequences: 4649 (3375)
Seq/√Len: 270.2
META: 0.945

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
100_H131_S3.1681.00
58_E147_R3.1661.00
73_Y91_N2.6531.00
151_K154_E2.6341.00
60_V65_L2.5801.00
130_L138_L2.4851.00
140_M148_V2.3741.00
106_E149_K2.3111.00
39_R112_A2.1501.00
48_A51_D2.0001.00
62_A151_K1.9991.00
42_I113_L1.9971.00
107_V111_I1.8641.00
97_A100_H1.8461.00
89_Y92_D1.7701.00
62_A66_A1.7471.00
3_R82_E1.7451.00
130_L134_Q1.7411.00
112_A123_A1.7351.00
27_P53_Y1.7211.00
40_L113_L1.7001.00
114_V121_E1.6891.00
81_R88_G1.6821.00
104_T134_Q1.6781.00
145_A149_K1.6731.00
34_T43_D1.6101.00
7_A11_N1.6091.00
81_R87_D1.5801.00
10_D14_R1.5791.00
7_A21_L1.5691.00
31_F42_I1.5471.00
51_D55_D1.5081.00
54_V148_V1.4921.00
98_I102_L1.4801.00
98_I152_L1.4751.00
35_G40_L1.4481.00
17_V22_L1.4471.00
9_V90_F1.4291.00
57_V148_V1.3831.00
104_T138_L1.3561.00
62_A154_E1.3541.00
64_A67_A1.3451.00
33_V40_L1.3341.00
117_K121_E1.3201.00
126_A130_L1.3181.00
2_I76_F1.3021.00
66_A155_L1.2761.00
142_P146_R1.2671.00
79_A82_E1.2621.00
73_Y89_Y1.2531.00
53_Y57_V1.2531.00
54_V58_E1.2481.00
1_L5_F1.2321.00
100_H134_Q1.2251.00
115_R118_V1.2201.00
13_A100_H1.2181.00
137_L140_M1.2111.00
143_E147_R1.2061.00
101_L152_L1.1971.00
80_Y93_R1.1971.00
61_D64_A1.1961.00
41_V112_A1.1891.00
10_D85_Y1.1621.00
121_E128_E1.1471.00
51_D144_N1.1451.00
32_A43_D1.1391.00
55_D143_E1.1341.00
62_A155_L1.1331.00
78_Q82_E1.1261.00
141_G144_N1.1181.00
40_L115_R1.1171.00
42_I47_Y1.1141.00
55_D147_R1.1021.00
99_D156_R1.0991.00
116_P119_L1.0971.00
77_Q89_Y1.0861.00
95_V99_D1.0861.00
68_L72_L1.0791.00
5_F9_V1.0751.00
45_A48_A1.0731.00
72_L76_F1.0561.00
57_V151_K1.0481.00
102_L153_R1.0461.00
104_T145_A1.0451.00
55_D58_E1.0451.00
19_A22_L1.0421.00
111_I138_L1.0401.00
128_E135_K1.0341.00
32_A46_N1.0321.00
101_L133_G1.0261.00
69_Y91_N1.0171.00
100_H104_T1.0051.00
75_L78_Q1.0041.00
58_E151_K1.0031.00
47_Y142_P0.9971.00
35_G41_V0.9951.00
151_K155_L0.9871.00
105_P134_Q0.9821.00
114_V123_A0.9771.00
85_Y88_G0.9621.00
89_Y95_V0.9621.00
104_T137_L0.9601.00
42_I122_F0.9481.00
99_D103_A0.9431.00
40_L120_Y0.9371.00
5_F76_F0.9291.00
35_G39_R0.9281.00
76_F94_L0.9181.00
107_V145_A0.9001.00
17_V21_L0.8941.00
91_N95_V0.8741.00
13_A97_A0.8721.00
90_F94_L0.8581.00
35_G38_G0.8471.00
95_V156_R0.8411.00
140_M145_A0.8350.99
42_I111_I0.8310.99
80_Y85_Y0.8290.99
27_P136_Q0.8210.99
77_Q81_R0.8190.99
92_D95_V0.8190.99
6_V10_D0.8140.99
36_R39_R0.8140.99
124_D127_L0.8080.99
138_L145_A0.8040.99
144_N147_R0.7960.99
132_A135_K0.7900.99
22_L27_P0.7900.99
54_V57_V0.7800.99
34_T44_P0.7740.99
36_R41_V0.7740.99
54_V140_M0.7730.99
34_T45_A0.7680.99
118_V121_E0.7650.99
150_A154_E0.7600.99
6_V76_F0.7600.99
113_L123_A0.7560.99
78_Q81_R0.7560.99
47_Y111_I0.7520.99
76_F90_F0.7520.99
140_M144_N0.7500.99
17_V136_Q0.7420.99
116_P121_E0.7380.99
107_V127_L0.7280.99
104_T149_K0.7250.99
147_R150_A0.7240.99
11_N21_L0.7220.99
56_A59_S0.7190.98
93_R96_E0.7180.98
54_V147_R0.7160.98
32_A45_A0.7090.98
143_E146_R0.7050.98
12_L133_G0.7030.98
34_T41_V0.7020.98
4_R8_T0.6940.98
108_E146_R0.6930.98
19_A26_P0.6910.98
80_Y90_F0.6910.98
43_D47_Y0.6900.98
80_Y86_P0.6890.98
67_A71_R0.6880.98
77_Q90_F0.6820.98
113_L116_P0.6780.98
18_P21_L0.6770.98
131_S134_Q0.6760.98
73_Y77_Q0.6760.98
25_L53_Y0.6740.98
64_A68_L0.6730.98
67_A70_R0.6680.98
69_Y73_Y0.6640.97
66_A70_R0.6640.97
52_P55_D0.6600.97
147_R151_K0.6580.97
42_I46_N0.6570.97
81_R89_Y0.6560.97
55_D59_S0.6550.97
126_A129_A0.6550.97
33_V120_Y0.6540.97
36_R40_L0.6510.97
10_D93_R0.6470.97
142_P145_A0.6430.97
76_F91_N0.6330.97
9_V93_R0.6320.97
94_L98_I0.6220.96
41_V110_P0.6190.96
51_D143_E0.6170.96
65_L68_L0.6140.96
73_Y95_V0.6140.96
100_H103_A0.6130.96
73_Y92_D0.6120.96
38_G41_V0.6090.96
127_L138_L0.6020.96
133_G136_Q0.5970.95
138_L142_P0.5950.95
63_A67_A0.5930.95
8_T11_N0.5930.95
22_L26_P0.5910.95
115_R121_E0.5910.95
11_N18_P0.5890.95
90_F93_R0.5870.95
107_V138_L0.5850.95
41_V111_I0.5830.95
18_P22_L0.5810.95
14_R85_Y0.5780.94
97_A101_L0.5760.94
61_D151_K0.5670.94
144_N148_V0.5570.93
106_E146_R0.5520.93
8_T22_L0.5520.93
23_P136_Q0.5500.93
99_D102_L0.5490.93
145_A148_V0.5490.93
33_V113_L0.5460.93
62_A65_L0.5460.93
79_A84_G0.5450.93
5_F23_P0.5410.92
51_D54_V0.5390.92
13_A93_R0.5360.92
101_L145_A0.5330.92
15_G25_L0.5300.91
81_R86_P0.5290.91
13_A16_K0.5270.91
23_P26_P0.5250.91
106_E145_A0.5220.91
46_N54_V0.5190.91
22_L53_Y0.5180.91
53_Y155_L0.5160.90
10_D16_K0.5160.90
8_T12_L0.5150.90
38_G112_A0.5110.90
107_V110_P0.5070.90
146_R150_A0.5020.89
12_L97_A0.5010.89
19_A27_P0.5000.89
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3c1yA 5 0.8782 21.3 0.943 Contact Map
2d0tA 1 0.8333 20.1 0.943 Contact Map
3ktaB 1 0.5705 15.1 0.946 Contact Map
4ka7A 1 0.7564 10.4 0.95 Contact Map
1y791 1 0.7628 9.1 0.952 Contact Map
4nqwA 1 0.6795 7.9 0.953 Contact Map
2wtgA 2 0.5128 7.9 0.953 Contact Map
2b1eA 1 0.8141 6.9 0.954 Contact Map
3i10A 1 0.609 6.4 0.955 Contact Map
1mvfD 1 0.2692 6.2 0.955 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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