GREMLIN Database
DUF3011 - Protein of unknown function (DUF3011)
PFAM: PF11218 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 197 (195)
Sequences: 671 (524)
Seq/√Len: 37.5
META: 0.893

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
110_G117_W2.8131.00
40_G47_W2.7781.00
30_D100_G2.6211.00
18_T21_G2.5771.00
165_L195_A2.5221.00
93_R127_A2.5101.00
100_G171_D2.3801.00
179_T191_R2.2870.99
101_S172_S2.2640.99
82_Y112_D2.1820.99
31_S101_S2.1650.99
17_D21_G2.1060.99
169_L196_E2.0950.99
5_E28_L2.0920.99
158_D162_G2.0580.99
175_V178_R2.0420.99
13_E42_D2.0380.99
32_P102_P2.0250.99
98_L169_L2.0170.99
152_R190_D2.0010.99
183_D186_G1.9590.98
24_L94_L1.9500.98
172_S179_T1.9270.98
37_R107_R1.9130.98
74_E146_E1.8920.98
87_T90_G1.8670.98
18_T22_V1.8390.98
42_D45_G1.8320.98
167_R196_E1.8230.97
9_G78_G1.8060.97
35_E105_E1.7740.97
94_L124_A1.7490.97
31_S38_T1.7150.96
78_G150_G1.7120.96
5_E146_E1.7100.96
41_Y111_Y1.7010.96
159_T162_G1.6830.96
101_S108_T1.6790.96
25_V57_A1.6240.95
28_L98_L1.6210.95
104_V107_R1.6020.95
148_D153_R1.5900.94
50_R120_R1.5830.94
181_G188_W1.5540.94
157_A162_G1.5290.93
23_R57_A1.5270.93
95_V127_A1.5190.93
35_E41_Y1.5170.93
31_S172_S1.4890.92
159_T182_Y1.4850.92
26_R55_E1.4680.91
74_E98_L1.4490.91
30_D171_D1.4450.91
49_D119_D1.4430.91
34_I37_R1.4370.91
108_T120_R1.4030.90
28_L55_E1.3970.89
86_D90_G1.3820.89
154_Y183_D1.3800.89
87_T92_V1.3730.88
11_R152_R1.3650.88
96_R125_E1.3520.88
125_E196_E1.3430.87
38_T108_T1.3060.86
178_R191_R1.2950.85
53_R123_R1.2830.85
9_G150_G1.2820.85
74_E123_R1.2770.85
175_V179_T1.2690.84
156_G159_T1.2630.84
28_L169_L1.2440.83
3_R28_L1.2220.82
11_R42_D1.2190.82
159_T163_V1.2090.81
72_R144_T1.2000.81
123_R194_R1.1940.80
98_L125_E1.1860.80
11_R80_R1.1840.80
13_E45_G1.1820.80
103_C122_C1.1670.79
143_V187_I1.1600.78
52_C56_F1.1510.78
40_G110_G1.1450.77
162_G182_Y1.1430.77
53_R194_R1.1380.77
82_Y114_G1.1300.76
144_T169_L1.1280.76
11_R49_D1.1260.76
106_G177_G1.1200.76
173_P179_T1.1080.75
45_G115_G1.1060.75
32_P38_T1.1030.75
16_A58_V1.0860.73
58_V128_V1.0840.73
22_V40_G1.0750.73
72_R98_L1.0700.72
108_T195_A1.0620.72
29_S170_S1.0520.71
80_R119_D1.0500.71
3_R26_R1.0480.71
144_T196_E1.0470.71
87_T111_Y1.0440.70
74_E169_L1.0400.70
7_D12_R1.0390.70
5_E74_E1.0380.70
158_D163_V1.0320.70
13_E82_Y1.0130.68
149_D153_R1.0000.67
142_T183_D0.9930.67
37_R50_R0.9760.65
77_D149_D0.9730.65
73_C83_C0.9710.65
94_L165_L0.9680.65
82_Y115_G0.9590.64
47_W117_W0.9480.63
99_S123_R0.9480.63
97_Q102_P0.9440.63
76_D148_D0.9430.62
47_W110_G0.9340.62
66_G137_G0.9290.61
43_R113_R0.9280.61
179_T190_D0.9230.61
79_R151_R0.9220.61
82_Y154_Y0.9180.60
38_T50_R0.9160.60
81_R153_R0.9150.60
39_W46_I0.9140.60
107_R120_R0.9140.60
36_G177_G0.9020.59
77_D119_D0.8940.58
24_L54_A0.8910.58
8_D12_R0.8900.58
48_V52_C0.8790.57
7_D76_D0.8710.56
70_T95_V0.8620.56
193_C197_F0.8600.55
17_D59_G0.8560.55
77_D81_R0.8540.55
89_G161_G0.8530.55
99_S170_S0.8490.54
72_R125_E0.8440.54
16_A21_G0.8270.52
60_G130_G0.8230.52
21_G59_G0.8180.52
104_V127_A0.8180.52
189_V193_C0.8170.52
25_V166_V0.8160.51
39_W109_W0.8120.51
3_R55_E0.8050.50
34_I104_V0.8050.50
33_C52_C0.8040.50
90_G111_Y0.8000.50
3_R72_R0.7970.50
57_A127_A0.7950.50
10_R79_R0.7950.50
4_C14_C0.7920.49
2_V16_A0.7910.49
15_P84_P0.7910.49
12_R153_R0.7810.48
112_D115_G0.7790.48
97_Q168_Q0.7750.48
24_L124_A0.7730.48
83_C103_C0.7690.47
83_C122_C0.7660.47
115_G186_G0.7520.46
53_R167_R0.7490.46
48_V56_F0.7480.45
16_A46_I0.7450.45
73_C126_F0.7410.45
134_G137_G0.7410.45
166_V178_R0.7400.45
63_G132_G0.7400.45
46_I58_V0.7380.45
35_E42_D0.7340.44
17_D22_V0.7310.44
88_R106_G0.7180.43
108_T179_T0.7150.43
165_L168_Q0.6990.41
25_V95_V0.6970.41
87_T128_V0.6960.41
65_G134_G0.6940.41
106_G109_W0.6930.41
64_G133_G0.6900.40
157_A160_R0.6890.40
44_G185_N0.6830.40
131_G136_G0.6820.40
99_S168_Q0.6770.39
105_E176_E0.6760.39
140_G143_V0.6760.39
40_G117_W0.6730.39
13_E44_G0.6650.38
192_G197_F0.6620.38
127_A130_G0.6570.38
150_G153_R0.6560.38
33_C56_F0.6530.37
3_R36_G0.6500.37
11_R47_W0.6480.37
76_D81_R0.6480.37
54_A112_D0.6460.37
118_V126_F0.6450.37
83_C117_W0.6390.36
22_V47_W0.6320.36
178_R182_Y0.6320.36
54_A96_R0.6310.35
122_C126_F0.6280.35
116_I128_V0.6280.35
25_V54_A0.6240.35
24_L165_L0.6220.35
77_D101_S0.6170.34
83_C109_W0.6160.34
42_D115_G0.6130.34
119_D190_D0.6120.34
85_A128_V0.6100.34
68_G140_G0.6090.34
18_T41_Y0.6060.33
102_P108_T0.6040.33
92_V163_V0.6030.33
62_G134_G0.6010.33
182_Y187_I0.5990.33
87_T115_G0.5980.33
159_T187_I0.5980.33
71_V116_I0.5980.33
160_R164_R0.5970.33
13_E18_T0.5960.33
22_V46_I0.5940.33
73_C122_C0.5940.33
44_G114_G0.5940.33
83_C126_F0.5930.32
26_R96_R0.5930.32
61_G65_G0.5930.32
70_T125_E0.5910.32
53_R124_A0.5910.32
102_P173_P0.5890.32
103_C126_F0.5860.32
74_E97_Q0.5840.32
105_E111_Y0.5830.32
194_R197_F0.5800.31
74_E144_T0.5780.31
33_C39_W0.5770.31
13_E35_E0.5760.31
9_G26_R0.5750.31
80_R152_R0.5750.31
10_R15_P0.5710.31
5_E53_R0.5700.31
116_I124_A0.5700.31
13_E40_G0.5690.31
142_T154_Y0.5630.30
21_G42_D0.5620.30
156_G162_G0.5620.30
173_P178_R0.5620.30
92_V128_V0.5610.30
43_R184_R0.5610.30
27_Q55_E0.5570.30
73_C103_C0.5570.30
156_G160_R0.5560.30
62_G71_V0.5550.30
104_V108_T0.5540.29
165_L170_S0.5540.29
74_E152_R0.5520.29
18_T45_G0.5510.29
73_C118_V0.5480.29
75_S121_G0.5480.29
145_C180_W0.5480.29
146_E196_E0.5450.29
54_A194_R0.5420.29
152_R162_G0.5390.28
90_G129_G0.5390.28
178_R187_I0.5370.28
27_Q51_G0.5340.28
47_W52_C0.5340.28
68_G84_P0.5320.28
92_V111_Y0.5300.28
6_S14_C0.5290.28
170_S192_G0.5270.28
11_R40_G0.5250.27
118_V122_C0.5250.27
61_G131_G0.5240.27
11_R45_G0.5230.27
165_L179_T0.5210.27
189_V192_G0.5210.27
124_A161_G0.5190.27
33_C40_G0.5180.27
73_C109_W0.5170.27
158_D176_E0.5170.27
39_W180_W0.5130.27
168_Q192_G0.5120.26
33_C48_V0.5110.26
155_C180_W0.5110.26
145_C155_C0.5090.26
48_V54_A0.5050.26
26_R32_P0.5030.26
45_G186_G0.5000.26
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2kn0A 1 0.1421 5.7 0.965 Contact Map
2kmzA 1 0.1624 3.9 0.968 Contact Map
2eqpA 1 0.198 1.4 0.974 Contact Map
2kjxA 1 0.1117 1.1 0.976 Contact Map
3d3zA 1 0.3147 0.9 0.978 Contact Map
2mfaA 1 0.2081 0.8 0.978 Contact Map
2j5hA 1 0.1066 0.8 0.978 Contact Map
2m35A 1 0.1015 0.8 0.978 Contact Map
2kerA 1 0.1421 0.8 0.978 Contact Map
1ok0A 1 0.1523 0.8 0.978 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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