GREMLIN Database
DUF2993 - Protein of unknown function (DUF2993)
PFAM: PF11209 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 225 (211)
Sequences: 4336 (3413)
Seq/√Len: 235.0
META: 0.612

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
74_D93_G5.9021.00
33_G50_D3.3011.00
4_R7_A3.0361.00
52_S69_D2.8671.00
13_R17_A2.8551.00
7_A11_E2.6431.00
48_S71_T2.5471.00
53_A56_V2.2731.00
64_R105_D2.1551.00
8_A12_R2.1221.00
36_P39_T2.0871.00
9_Y13_R2.0811.00
24_L28_P2.0541.00
5_V9_Y2.0081.00
102_T105_D1.9791.00
13_R16_D1.9741.00
153_T156_L1.9671.00
50_D71_T1.9581.00
3_D7_A1.9411.00
160_V163_G1.9051.00
216_T221_V1.8991.00
76_R93_G1.8761.00
19_R27_D1.8741.00
15_A19_R1.8221.00
69_D98_T1.7921.00
123_I127_Q1.7701.00
103_Y218_G1.7641.00
72_L95_A1.7461.00
103_Y215_V1.7291.00
131_L134_G1.7191.00
33_G48_S1.7161.00
214_E221_V1.7081.00
17_A20_S1.6971.00
72_L75_V1.6051.00
98_T221_V1.6041.00
97_G224_A1.5961.00
150_V156_L1.5931.00
11_E32_I1.5711.00
121_L124_S1.5541.00
66_A102_T1.5331.00
130_D133_N1.5141.00
121_L126_L1.5111.00
135_T139_T1.5061.00
35_F39_T1.4861.00
189_D193_D1.4861.00
212_S223_T1.4811.00
121_L125_D1.4811.00
73_D94_S1.4681.00
175_G178_G1.4631.00
134_G139_T1.4631.00
38_L42_L1.4611.00
98_T223_T1.4601.00
48_S73_D1.4531.00
216_T219_G1.4531.00
12_R16_D1.4491.00
105_D108_R1.4381.00
124_S127_Q1.4151.00
132_G137_E1.4101.00
5_V8_A1.4061.00
103_Y219_G1.3671.00
34_G40_Q1.3661.00
122_L125_D1.3641.00
41_L46_Y1.3501.00
165_L169_P1.3351.00
134_G140_G1.3141.00
55_G64_R1.3061.00
107_N110_L1.3051.00
3_D11_E1.2941.00
191_L195_L1.2591.00
2_A5_V1.2571.00
151_S156_L1.2511.00
154_A158_V1.2351.00
40_Q47_D1.2251.00
132_G140_G1.2181.00
132_G135_T1.2001.00
46_Y206_F1.1971.00
129_G133_N1.1951.00
147_G156_L1.1921.00
131_L140_G1.1821.00
39_T43_S1.1811.00
133_N139_T1.1721.00
16_D20_S1.1711.00
123_I126_L1.1701.00
133_N140_G1.1701.00
62_G65_I1.1681.00
132_G139_T1.1661.00
8_A11_E1.1541.00
152_V156_L1.1481.00
146_G149_P1.1451.00
147_G154_A1.1321.00
79_L82_L1.1271.00
131_L137_E1.1201.00
150_V153_T1.1201.00
100_T219_G1.1131.00
32_I49_V1.1111.00
26_E55_G1.1061.00
46_Y49_V1.0881.00
131_L135_T1.0691.00
174_L178_G1.0621.00
134_G141_D1.0611.00
107_N111_G1.0541.00
148_L154_A1.0441.00
2_A6_A1.0331.00
40_Q46_Y1.0291.00
11_E15_A1.0241.00
39_T99_A1.0231.00
104_A108_R1.0211.00
167_L197_F1.0201.00
15_A18_L1.0111.00
103_Y107_N1.0091.00
45_R76_R1.0011.00
142_T145_L0.9971.00
3_D10_A0.9941.00
150_V154_A0.9921.00
204_L207_G0.9891.00
24_L27_D0.9851.00
25_A28_P0.9821.00
149_P155_T0.9811.00
146_G154_A0.9751.00
149_P153_T0.9731.00
122_L127_Q0.9671.00
159_V163_G0.9611.00
165_L213_V0.9611.00
156_L160_V0.9601.00
135_T141_D0.9561.00
67_S100_T0.9481.00
15_A30_V0.9451.00
149_P156_L0.9351.00
122_L126_L0.9331.00
183_L187_L0.9311.00
195_L198_T0.9311.00
7_A32_I0.9301.00
134_G138_L0.9211.00
15_A28_P0.9191.00
188_L192_L0.9151.00
151_S155_T0.9151.00
44_G79_L0.9131.00
150_V155_T0.9111.00
169_P173_T0.9071.00
149_P154_A0.9021.00
76_R90_A0.8830.99
100_T221_V0.8820.99
129_G132_G0.8790.99
45_R93_G0.8760.99
157_T170_T0.8730.99
169_P172_V0.8710.99
132_G138_L0.8640.99
74_D92_A0.8610.99
3_D37_F0.8580.99
45_R74_D0.8570.99
164_T200_D0.8560.99
121_L127_Q0.8550.99
139_T142_T0.8510.99
61_G64_R0.8490.99
10_A32_I0.8480.99
181_Q184_P0.8430.99
35_F40_Q0.8400.99
73_D96_T0.8400.99
174_L177_G0.8370.99
136_V145_L0.8350.99
131_L139_T0.8340.99
29_D52_S0.8290.99
159_V168_T0.8290.99
221_V224_A0.8240.99
6_A38_L0.8190.99
130_D136_V0.8150.99
34_G39_T0.8140.99
192_L195_L0.8100.99
36_P40_Q0.8080.99
132_G136_V0.8010.99
134_G137_E0.7990.99
7_A14_A0.7880.99
190_A193_D0.7870.99
6_A10_A0.7870.99
14_A17_A0.7860.99
87_L91_T0.7840.99
9_Y12_R0.7830.99
28_P37_F0.7830.99
77_L87_L0.7820.99
28_P53_A0.7660.98
37_F46_Y0.7660.98
55_G66_A0.7640.98
157_T168_T0.7630.98
208_L224_A0.7580.98
159_V162_D0.7560.98
184_P188_L0.7530.98
68_L99_A0.7520.98
18_L53_A0.7490.98
63_L109_A0.7430.98
81_S86_K0.7420.98
130_D134_G0.7410.98
55_G105_D0.7330.98
193_D196_D0.7240.98
189_D192_L0.7180.98
166_R169_P0.7170.98
138_L143_V0.7100.97
3_D34_G0.7030.97
76_R91_T0.7020.97
55_G67_S0.7010.97
184_P191_L0.7000.97
151_S154_A0.6970.97
195_L199_L0.6960.97
4_R39_T0.6940.97
30_V51_V0.6860.97
218_G221_V0.6850.97
28_P36_P0.6770.97
22_L53_A0.6770.97
133_N145_L0.6720.96
6_A19_R0.6720.96
148_L151_S0.6710.96
169_P177_G0.6690.96
188_L191_L0.6670.96
41_L44_G0.6660.96
161_G166_R0.6650.96
13_R18_L0.6620.96
188_L197_F0.6610.96
44_G77_L0.6610.96
131_L138_L0.6550.96
129_G140_G0.6480.96
206_F210_L0.6470.96
7_A39_T0.6450.95
138_L141_D0.6420.95
65_I110_L0.6370.95
32_I37_F0.6350.95
204_L208_L0.6340.95
178_G183_L0.6340.95
11_E14_A0.6340.95
19_R24_L0.6320.95
31_S50_D0.6310.95
6_A37_F0.6270.95
19_R28_P0.6270.95
129_G138_L0.6260.95
153_T173_T0.6240.95
73_D92_A0.6230.95
47_D74_D0.6190.94
163_G168_T0.6190.94
75_V92_A0.6180.94
76_R80_S0.6180.94
32_I39_T0.6160.94
147_G151_S0.6150.94
211_T224_A0.6150.94
42_L79_L0.6150.94
172_V175_G0.6140.94
37_F40_Q0.6130.94
63_L68_L0.6120.94
12_R15_A0.6100.94
190_A196_D0.6090.94
134_G145_L0.6070.94
25_A53_A0.6060.94
7_A43_S0.6060.94
31_S52_S0.6030.94
56_V105_D0.6030.94
77_L99_A0.6000.93
191_L194_A0.5990.93
17_A21_Q0.5950.93
57_T62_G0.5930.93
25_A34_G0.5920.93
78_D89_L0.5880.93
43_S50_D0.5870.93
148_L152_V0.5870.93
21_Q32_I0.5850.93
57_T187_L0.5840.92
34_G37_F0.5840.92
130_D140_G0.5840.92
101_L106_L0.5820.92
133_N138_L0.5820.92
49_V75_V0.5810.92
46_Y75_V0.5790.92
14_A18_L0.5760.92
214_E223_T0.5730.92
4_R103_Y0.5700.92
19_R22_L0.5680.91
66_A105_D0.5640.91
213_V222_I0.5630.91
46_Y72_L0.5610.91
129_G136_V0.5610.91
7_A20_S0.5600.91
68_L72_L0.5600.91
54_R67_S0.5580.91
205_P210_L0.5570.91
192_L196_D0.5540.90
104_A107_N0.5530.90
194_A198_T0.5530.90
173_T194_A0.5520.90
164_T198_T0.5510.90
135_T138_L0.5510.90
159_V166_R0.5500.90
151_S160_V0.5450.90
76_R92_A0.5420.89
74_D81_S0.5410.89
185_P189_D0.5370.89
40_Q49_V0.5360.89
166_R198_T0.5360.89
74_D91_T0.5360.89
126_L135_T0.5330.89
147_G153_T0.5320.89
19_R23_G0.5320.89
104_A218_G0.5320.89
34_G47_D0.5310.88
58_V200_D0.5310.88
110_L169_P0.5290.88
167_L173_T0.5280.88
78_D81_S0.5240.88
56_V68_L0.5210.87
138_L142_T0.5210.87
47_D222_I0.5200.87
108_R112_S0.5160.87
16_D19_R0.5160.87
66_A219_G0.5120.87
54_R66_A0.5120.87
68_L74_D0.5120.87
55_G102_T0.5090.86
31_S55_G0.5030.86
70_A92_A0.5020.86
184_P189_D0.5010.85
207_G213_V0.5000.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3l6iA 2 0.5778 82 0.871 Contact Map
3oa1A 1 0.4222 7.9 0.931 Contact Map
4k3lA 2 0.4133 5.8 0.935 Contact Map
1vyiA 1 0.44 5 0.937 Contact Map
3t0pA 2 0.4711 4.1 0.939 Contact Map
4alzA 1 0.4267 3.9 0.94 Contact Map
2yjlA 1 0.3022 3.6 0.941 Contact Map
4trtA 2 0.4444 3.6 0.941 Contact Map
2wzlA 1 0.4489 3.6 0.941 Contact Map
4m4dA 1 0.8667 3.2 0.943 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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