GREMLIN Database
DUF2992 - Protein of unknown function (DUF2992)
PFAM: PF11208 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 132 (132)
Sequences: 1400 (1075)
Seq/√Len: 93.6
META: 0.711

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
92_K95_Q5.4361.00
45_N48_R3.9951.00
85_T88_Q3.4081.00
118_F122_Q2.6631.00
4_F11_V2.5451.00
40_E44_K2.5171.00
116_R120_L2.5051.00
16_R23_S2.4911.00
14_F46_Y2.3241.00
115_E119_E2.3161.00
122_Q125_K2.3021.00
84_G89_Q2.3001.00
14_F42_V2.2501.00
108_E112_A2.2011.00
22_L87_A2.1981.00
14_F27_V2.1151.00
39_Y43_L2.1081.00
123_Q127_E2.0911.00
89_Q92_K1.8791.00
105_R109_Q1.8571.00
106_S109_Q1.8021.00
70_L74_A1.7561.00
5_F8_P1.7341.00
1_L12_G1.7031.00
84_G88_Q1.6091.00
113_E116_R1.5891.00
12_G29_F1.5661.00
22_L55_V1.5091.00
1_L14_F1.4641.00
94_Q97_Q1.4451.00
13_V82_G1.4431.00
64_K70_L1.4150.99
65_I70_L1.3870.99
111_E115_E1.3840.99
65_I73_E1.3450.99
18_E23_S1.3250.99
117_K120_L1.3150.99
53_P94_Q1.3130.99
94_Q98_N1.3030.99
107_R111_E1.2900.99
121_K125_K1.2790.99
71_Q74_A1.2700.99
25_C49_L1.2590.99
112_A116_R1.2500.99
75_R78_L1.2490.99
127_E132_H1.2450.99
69_R72_R1.2090.98
18_E21_K1.2080.98
127_E130_R1.2080.98
95_Q98_N1.1960.98
101_E104_K1.1910.98
13_V22_L1.1870.98
118_F121_K1.1690.98
46_Y51_F1.1450.97
111_E114_K1.1440.97
113_E117_K1.1390.97
106_S110_R1.1290.97
129_H132_H1.1240.97
4_F13_V1.0970.97
25_C51_F1.0910.97
41_F45_N1.0730.96
5_F10_W1.0690.96
6_E26_K1.0610.96
114_K117_K1.0410.96
128_K131_G1.0290.95
110_R114_K1.0280.95
4_F22_L1.0260.95
74_A77_Q1.0150.95
1_L42_V1.0130.95
125_K129_H0.9550.93
73_E77_Q0.9450.93
10_W32_E0.9410.93
86_K94_Q0.9320.92
53_P97_Q0.9280.92
67_P75_R0.9270.92
14_F23_S0.9190.92
92_K96_E0.8850.90
104_K108_E0.8780.90
85_T89_Q0.8760.90
120_L129_H0.8710.89
36_Y40_E0.8630.89
34_K38_V0.8580.89
37_E41_F0.8260.87
63_K87_A0.8100.86
107_R124_K0.8090.86
67_P72_R0.8070.85
17_I57_A0.8070.85
126_K132_H0.7970.85
98_N109_Q0.7960.85
8_P11_V0.7960.85
109_Q112_A0.7890.84
63_K70_L0.7850.84
93_L97_Q0.7840.84
83_I92_K0.7770.83
125_K130_R0.7520.81
74_A78_L0.7480.81
70_L73_E0.7460.81
60_K116_R0.7440.80
27_V45_N0.7360.80
55_V58_E0.7320.79
64_K73_E0.7240.79
46_Y125_K0.7210.78
98_N101_E0.7120.77
1_L10_W0.7090.77
98_N105_R0.7030.77
14_F51_F0.7030.77
2_T10_W0.7020.76
46_Y76_K0.6990.76
15_E22_L0.6970.76
57_A60_K0.6960.76
84_G90_A0.6880.75
34_K37_E0.6790.74
17_I21_K0.6790.74
120_L123_Q0.6700.73
78_L81_T0.6670.73
21_K54_A0.6660.73
73_E76_K0.6610.72
71_Q86_K0.6580.72
118_F125_K0.6570.72
47_Y80_N0.6570.72
40_E63_K0.6550.71
4_F12_G0.6520.71
27_V42_V0.6520.71
55_V87_A0.6490.71
92_K98_N0.6480.71
50_R97_Q0.6450.70
125_K128_K0.6430.70
86_K118_F0.6420.70
48_R112_A0.6400.70
51_F86_K0.6370.69
56_E59_V0.6360.69
61_E79_Q0.6250.68
17_I87_A0.6190.67
91_L94_Q0.6150.67
102_R106_S0.6110.66
1_L38_V0.6100.66
61_E65_I0.6050.65
38_V67_P0.6000.65
11_V26_K0.5990.64
11_V25_C0.5990.64
61_E64_K0.5970.64
124_K128_K0.5960.64
89_Q93_L0.5930.64
16_R51_F0.5850.63
46_Y50_R0.5850.63
3_V16_R0.5820.62
65_I74_A0.5820.62
119_E123_Q0.5800.62
50_R107_R0.5780.62
27_V51_F0.5760.61
26_K61_E0.5760.61
108_E114_K0.5760.61
80_N114_K0.5710.61
9_F28_T0.5640.60
118_F132_H0.5640.60
47_Y81_T0.5630.60
2_T15_E0.5630.60
70_L78_L0.5630.60
9_F103_K0.5620.60
88_Q96_E0.5620.60
3_V13_V0.5610.59
26_K29_F0.5580.59
102_R113_E0.5570.59
17_I22_L0.5570.59
100_K106_S0.5550.59
29_F35_D0.5520.58
2_T132_H0.5490.58
28_T71_Q0.5470.58
105_R108_E0.5470.58
42_V47_Y0.5430.57
84_G92_K0.5420.57
53_P120_L0.5360.56
17_I20_G0.5350.56
55_V94_Q0.5330.56
115_E123_Q0.5320.56
58_E63_K0.5290.55
52_S55_V0.5250.55
24_V94_Q0.5240.54
65_I79_Q0.5240.54
46_Y75_R0.5220.54
15_E24_V0.5200.54
21_K24_V0.5170.53
53_P56_E0.5160.53
23_S51_F0.5150.53
75_R81_T0.5150.53
86_K90_A0.5130.53
60_K63_K0.5100.52
94_Q129_H0.5100.52
5_F43_L0.5070.52
11_V28_T0.5070.52
107_R129_H0.5060.52
3_V10_W0.5050.52
25_C114_K0.5050.52
49_L89_Q0.5040.52
77_Q126_K0.5030.51
27_V41_F0.5030.51
68_K76_K0.5020.51
29_F41_F0.5000.51
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2oq1A 1 0.4242 44 0.922 Contact Map
2y3aB 1 0.4242 43 0.923 Contact Map
2hdvA 1 0.4318 39.9 0.924 Contact Map
2cs0A 1 0.4697 38.8 0.925 Contact Map
2mk2A 1 0.4091 38.8 0.925 Contact Map
4tziA 1 0.4242 38.7 0.925 Contact Map
4u5wB 2 0.4318 37.6 0.925 Contact Map
1nrvA 1 0.3864 37.6 0.925 Contact Map
2ecdA 1 0.4848 37.1 0.926 Contact Map
1ka6A 1 0.447 36.9 0.926 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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