GREMLIN Database
EccE - Putative type VII ESX secretion system translocon, EccE
PFAM: PF11203 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 99 (95)
Sequences: 1157 (758)
Seq/√Len: 77.8
META: 0.605

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
28_G31_G3.5041.00
14_D17_D3.4561.00
11_L43_L3.2751.00
26_G31_G3.1231.00
27_G31_G2.9851.00
88_R93_Y2.6991.00
58_D61_E2.4631.00
22_V31_G2.2021.00
53_R75_L2.1161.00
86_G95_T2.0741.00
25_R35_A1.8491.00
55_R61_E1.8181.00
40_A56_V1.8131.00
89_G94_H1.7731.00
58_D62_L1.5791.00
64_A77_P1.5700.99
81_R88_R1.5360.99
18_N21_A1.4990.99
13_L36_L1.4900.99
34_R37_A1.4870.99
41_R45_D1.4340.99
62_L66_L1.3890.99
50_A81_R1.3680.99
11_L61_E1.3340.98
22_V26_G1.3140.98
74_P83_T1.3040.98
40_A51_G1.2780.98
35_A42_R1.2530.97
35_A39_A1.2460.97
15_P41_R1.2270.97
36_L98_W1.2270.97
38_A45_D1.2150.97
18_N22_V1.2100.97
22_V27_G1.1660.96
87_W94_H1.1550.96
60_D67_A1.1470.96
38_A42_R1.1420.96
66_L69_L1.1400.95
12_R15_P1.1180.95
18_N31_G1.1160.95
45_D62_L1.1080.95
37_A81_R1.1020.95
13_L82_E1.1010.95
25_R31_G1.0920.94
66_L87_W1.0910.94
2_P46_R1.0690.94
14_D57_L1.0640.93
61_E64_A1.0330.92
9_L53_R1.0030.91
9_L52_L1.0000.91
2_P87_W0.9910.91
73_A77_P0.9840.91
26_G35_A0.9770.90
64_A68_R0.9710.90
27_G32_A0.9410.88
62_L68_R0.9280.88
25_R42_R0.9200.87
57_L66_L0.9140.87
43_L46_R0.9030.86
3_A35_A0.8970.86
7_T48_R0.8890.85
93_Y98_W0.8860.85
40_A93_Y0.8700.84
46_R69_L0.8610.84
7_T13_L0.8610.84
14_D65_A0.8520.83
90_D94_H0.8440.82
22_V36_L0.8330.81
3_A28_G0.8060.79
60_D72_G0.8050.79
44_A49_E0.8020.79
22_V87_W0.8000.79
60_D63_A0.8000.79
9_L72_G0.7900.78
15_P18_N0.7830.77
66_L94_H0.7800.77
90_D97_Y0.7620.75
67_A83_T0.7610.75
51_G98_W0.7450.74
21_A27_G0.7440.74
66_L71_G0.7440.74
87_W92_G0.7330.73
57_L82_E0.7240.72
39_A55_R0.7200.71
78_A81_R0.7110.70
12_R38_A0.6960.69
91_G95_T0.6850.67
88_R91_G0.6720.66
72_G94_H0.6630.65
75_L85_R0.6570.64
50_A83_T0.6550.64
74_P78_A0.6540.64
15_P31_G0.6540.64
12_R35_A0.6540.64
69_L72_G0.6520.64
63_A67_A0.6460.63
23_A29_V0.6450.63
67_A78_A0.6200.60
15_P45_D0.6120.59
83_T86_G0.6120.59
22_V28_G0.6110.59
73_A97_Y0.6050.58
62_L87_W0.6050.58
66_L85_R0.6040.58
26_G34_R0.6030.58
54_A88_R0.6000.57
7_T68_R0.6000.57
10_A69_L0.5980.57
82_E87_W0.5940.56
5_R48_R0.5930.56
70_A87_W0.5900.56
61_E68_R0.5790.55
25_R40_A0.5690.53
45_D48_R0.5670.53
25_R39_A0.5660.53
65_A86_G0.5600.52
75_L83_T0.5580.52
23_A28_G0.5550.52
28_G34_R0.5540.51
60_D78_A0.5530.51
9_L59_A0.5410.50
9_L97_Y0.5380.49
38_A54_A0.5310.48
86_G93_Y0.5310.48
19_A94_H0.5300.48
5_R39_A0.5300.48
94_H98_W0.5280.48
27_G34_R0.5270.48
16_A76_A0.5250.48
21_A25_R0.5240.48
22_V32_A0.5240.48
11_L95_T0.5200.47
74_P77_P0.5200.47
64_A67_A0.5180.47
13_L32_A0.5180.47
37_A41_R0.5160.47
67_A71_G0.5140.46
6_T53_R0.5140.46
24_A49_E0.5080.46
17_D22_V0.5060.45
9_L45_D0.5050.45
53_R60_D0.5000.44
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3jstA 1 0.3636 5.3 0.903 Contact Map
3agdA 2 0.5253 4.3 0.907 Contact Map
2v6uA 4 0.3939 4.2 0.907 Contact Map
4wilA 4 0.3737 3.4 0.912 Contact Map
3hxaA 5 0.3737 2.7 0.916 Contact Map
2vliA 2 0.7677 2.2 0.92 Contact Map
4onlB 1 0.5152 2.1 0.92 Contact Map
3i1aA 1 0.404 2 0.921 Contact Map
1tteA 1 0.5253 2 0.922 Contact Map
1fxtA 1 0.5152 1.8 0.924 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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