GREMLIN Database
DUF2891 - Protein of unknown function (DUF2891)
PFAM: PF11199 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 323 (322)
Sequences: 4703 (3035)
Seq/√Len: 169.1
META: 0.888

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
185_R188_R5.1051.00
196_C211_C3.7931.00
205_E258_K3.0811.00
171_R179_A2.8971.00
130_Q134_D2.6751.00
194_R233_A2.6551.00
179_A183_R2.6221.00
67_A71_R2.6071.00
37_A83_I2.5411.00
187_R191_L2.5181.00
216_D219_R2.4821.00
92_R95_R2.4741.00
29_R33_E2.4661.00
167_L179_A2.4351.00
167_L171_R2.4321.00
121_D124_R2.3921.00
287_R291_L2.3501.00
184_E188_R2.3311.00
141_L175_D2.3031.00
75_D124_R2.2841.00
223_P226_E2.1891.00
140_L166_A2.1781.00
167_L183_R2.1541.00
155_E258_K2.1481.00
83_I87_V2.1351.00
183_R187_R2.1181.00
71_R121_D2.0821.00
11_H77_S2.0781.00
55_V74_L2.0591.00
135_A139_R2.0501.00
171_R183_R2.0351.00
187_R226_E2.0101.00
23_N94_G2.0051.00
163_L182_I1.9981.00
59_R116_E1.9701.00
308_G313_E1.9571.00
148_T252_S1.9501.00
25_D30_P1.9381.00
273_L290_L1.9351.00
295_D299_A1.9341.00
75_D125_W1.9241.00
186_A218_M1.9211.00
219_R275_G1.8971.00
13_E32_R1.8931.00
137_A175_D1.8791.00
168_D220_R1.8721.00
87_V135_A1.8651.00
4_R69_E1.8551.00
115_R126_A1.8391.00
254_R263_D1.8351.00
214_E234_F1.8341.00
11_H76_A1.7911.00
71_R119_D1.7741.00
216_D275_G1.7671.00
195_D237_G1.7531.00
112_A172_A1.7471.00
117_W122_A1.7371.00
140_L162_A1.7351.00
80_A128_N1.7281.00
20_H89_Y1.7191.00
91_R135_A1.7151.00
115_R173_A1.7101.00
37_A82_N1.7021.00
138_E142_D1.6931.00
14_Y30_P1.6641.00
75_D121_D1.6581.00
30_P33_E1.6561.00
118_D123_R1.6201.00
111_A126_A1.5901.00
109_K112_A1.5821.00
21_V42_F1.5741.00
249_A266_N1.5601.00
8_A12_R1.5601.00
153_V157_S1.5541.00
111_A133_A1.5461.00
137_A178_L1.5421.00
185_R189_F1.5411.00
148_T250_V1.5231.00
59_R113_E1.5071.00
78_L128_N1.5011.00
166_A178_L1.4991.00
141_L181_L1.4981.00
18_L34_L1.4941.00
307_G313_E1.4861.00
4_R66_E1.4711.00
180_A184_E1.4651.00
78_L125_W1.4561.00
181_L185_R1.4271.00
55_V58_L1.4151.00
53_L321_V1.4101.00
73_A77_S1.4091.00
79_T82_N1.4021.00
227_F276_I1.3971.00
176_A179_A1.3801.00
111_A115_R1.3751.00
58_L71_R1.3701.00
17_K21_V1.3601.00
121_D125_W1.3601.00
178_L182_I1.3561.00
164_G220_R1.3531.00
13_E16_N1.3461.00
90_L136_I1.3371.00
115_R133_A1.3221.00
252_S259_L1.3211.00
141_L177_A1.3121.00
37_A77_S1.3121.00
109_K165_L1.3021.00
37_A78_L1.2801.00
66_E69_E1.2781.00
25_D32_R1.2771.00
9_C41_C1.2661.00
42_F257_G1.2621.00
164_G216_D1.2591.00
219_R279_A1.2501.00
135_A138_E1.2331.00
227_F231_L1.2301.00
4_R8_A1.2291.00
20_H34_L1.2291.00
24_S27_D1.2231.00
58_L67_A1.2211.00
59_R117_W1.2141.00
10_V54_L1.2111.00
137_A141_L1.2051.00
141_L178_L1.2041.00
55_V114_L1.1981.00
97_S257_G1.1941.00
276_I280_L1.1901.00
80_A84_A1.1871.00
56_R60_L1.1851.00
191_L222_L1.1831.00
14_Y25_D1.1831.00
2_F6_A1.1751.00
182_I217_L1.1721.00
203_S206_D1.1721.00
257_G311_E1.1591.00
84_A88_A1.1591.00
23_N92_R1.1531.00
133_A137_A1.1501.00
193_D214_E1.1401.00
54_L70_I1.1331.00
231_L238_L1.1161.00
155_E205_E1.1061.00
51_H74_L1.1001.00
116_E172_A1.0871.00
115_R130_Q1.0871.00
213_A272_C1.0781.00
69_E72_A1.0761.00
79_T128_N1.0661.00
14_Y22_L1.0550.99
56_R113_E1.0520.99
145_P181_L1.0510.99
166_A182_I1.0510.99
208_L213_A1.0440.99
90_L135_A1.0400.99
186_A217_L1.0390.99
274_R295_D1.0360.99
292_A296_A1.0290.99
84_A87_V1.0250.99
85_A88_A1.0250.99
115_R172_A1.0230.99
96_A142_D1.0210.99
10_V73_A1.0180.99
11_H73_A1.0100.99
190_Y214_E1.0010.99
111_A169_Y0.9980.99
76_A82_N0.9930.99
232_D284_D0.9930.99
277_A291_L0.9900.99
22_L28_V0.9890.99
215_A276_I0.9850.99
5_L50_G0.9830.99
196_C234_F0.9780.99
87_V91_R0.9780.99
274_R298_L0.9740.99
127_A130_Q0.9720.99
57_L64_L0.9700.99
146_K253_D0.9580.99
66_E70_I0.9570.99
16_N39_Y0.9480.99
37_A51_H0.9470.99
176_A180_A0.9410.99
275_G278_A0.9390.99
211_C235_L0.9380.99
197_P200_Y0.9380.99
255_S309_D0.9330.99
20_H28_V0.9330.99
64_L70_I0.9300.99
3_A57_L0.9280.99
41_C47_S0.9260.99
6_A53_L0.9210.99
96_A146_K0.9190.99
3_A54_L0.9170.99
104_W136_I0.9120.98
83_I128_N0.9120.98
78_L83_I0.9020.98
198_A245_L0.9000.98
266_N297_H0.9000.98
142_D146_K0.8950.98
134_D175_D0.8930.98
18_L22_L0.8930.98
5_L306_T0.8890.98
43_D46_S0.8880.98
53_L57_L0.8830.98
147_L189_F0.8750.98
101_P157_S0.8690.98
167_L182_I0.8690.98
37_A79_T0.8670.98
5_L9_C0.8640.98
109_K168_D0.8640.98
129_L133_A0.8620.98
143_W147_L0.8610.98
167_L217_L0.8600.98
47_S51_H0.8590.98
72_A76_A0.8570.98
77_S82_N0.8560.98
148_T249_A0.8540.98
157_S205_E0.8540.98
11_H39_Y0.8530.98
224_P279_A0.8510.98
123_R126_A0.8510.98
23_N95_R0.8480.98
247_E250_V0.8480.98
169_Y178_L0.8390.97
260_A307_G0.8390.97
242_P246_L0.8390.97
149_Y249_A0.8370.97
216_D220_R0.8280.97
288_A292_A0.8220.97
152_R193_D0.8210.97
281_P287_R0.8200.97
247_E296_A0.8130.97
224_P228_A0.8120.97
167_L221_V0.8100.97
107_L129_L0.8090.97
180_A183_R0.8070.97
301_G304_H0.8030.97
101_P144_L0.8000.97
19_D42_F0.7900.96
119_D122_A0.7890.96
229_A232_D0.7880.96
228_A281_P0.7880.96
88_A91_R0.7870.96
109_K116_E0.7870.96
13_E34_L0.7850.96
35_H89_Y0.7840.96
153_V203_S0.7780.96
195_D199_A0.7770.96
241_G289_A0.7760.96
151_I163_L0.7750.96
9_C50_G0.7650.96
159_T189_F0.7630.95
198_A244_T0.7610.95
317_A322_Y0.7590.95
237_G240_A0.7550.95
148_T259_L0.7550.95
277_A294_A0.7540.95
153_V205_E0.7540.95
104_W140_L0.7520.95
182_I186_A0.7520.95
3_A70_I0.7510.95
39_Y77_S0.7500.95
83_I129_L0.7480.95
169_Y173_A0.7480.95
134_D138_E0.7470.95
313_E317_A0.7450.95
187_R222_L0.7420.95
296_A299_A0.7400.95
122_A126_A0.7340.94
158_N213_A0.7300.94
232_D286_R0.7300.94
17_K42_F0.7300.94
149_Y254_R0.7290.94
306_T313_E0.7270.94
101_P143_W0.7260.94
53_L56_R0.7160.94
114_L129_L0.7150.94
1_R4_R0.7140.94
215_A280_L0.7100.93
73_A76_A0.7070.93
273_L293_A0.7070.93
20_H95_R0.7060.93
89_Y95_R0.7060.93
245_L293_A0.7050.93
147_L159_T0.7030.93
34_L89_Y0.7030.93
239_A289_A0.7020.93
159_T190_Y0.7020.93
71_R75_D0.6970.93
191_L218_M0.6970.93
58_L117_W0.6960.93
112_A165_L0.6950.93
122_A125_W0.6950.93
6_A10_V0.6910.92
298_L302_L0.6900.92
152_R214_E0.6900.92
164_G213_A0.6850.92
190_Y204_G0.6850.92
108_L136_I0.6850.92
17_K20_H0.6830.92
10_V55_V0.6830.92
299_A303_P0.6830.92
72_A75_D0.6820.92
101_P151_I0.6760.92
229_A233_A0.6760.92
57_L66_E0.6760.92
186_A221_V0.6750.92
68_A72_A0.6710.91
238_L246_L0.6710.91
242_P245_L0.6700.91
177_A180_A0.6640.91
305_V313_E0.6580.90
18_L27_D0.6580.90
208_L268_S0.6530.90
2_F53_L0.6520.90
171_R220_R0.6500.90
211_C234_F0.6500.90
81_E84_A0.6480.90
100_R104_W0.6460.90
305_V309_D0.6460.90
69_E73_A0.6450.90
130_Q133_A0.6440.89
3_A66_E0.6400.89
126_A133_A0.6400.89
304_H307_G0.6390.89
51_H73_A0.6360.89
105_A162_A0.6320.89
283_G287_R0.6310.89
291_L295_D0.6250.88
49_H318_S0.6240.88
108_L166_A0.6230.88
170_A179_A0.6230.88
195_D233_A0.6230.88
238_L289_A0.6210.88
289_A293_A0.6210.88
164_G219_R0.6190.88
55_V117_W0.6190.88
53_L318_S0.6190.88
151_I258_K0.6190.88
51_H56_R0.6190.88
249_A262_L0.6180.88
125_W128_N0.6180.88
49_H319_F0.6170.87
109_K169_Y0.6170.87
14_Y24_S0.6160.87
101_P105_A0.6160.87
232_D239_A0.6140.87
272_C275_G0.6130.87
143_W205_E0.6130.87
80_A127_A0.6120.87
16_N31_P0.6110.87
87_V132_L0.6100.87
164_G208_L0.6090.87
5_L8_A0.6070.87
213_A216_D0.6060.86
260_A311_E0.6050.86
157_S203_S0.6050.86
20_H27_D0.6050.86
16_N19_D0.6030.86
89_Y98_F0.5980.86
268_S271_W0.5950.85
216_D272_C0.5940.85
13_E30_P0.5940.85
296_A300_A0.5910.85
19_D22_L0.5890.85
198_A246_L0.5890.85
112_A115_R0.5890.85
8_A313_E0.5890.85
57_L321_V0.5880.85
278_A291_L0.5880.85
272_C276_I0.5870.85
6_A9_C0.5850.85
64_L67_A0.5850.85
284_D287_R0.5850.85
160_A190_Y0.5850.85
78_L82_N0.5810.84
274_R294_A0.5810.84
140_L145_P0.5810.84
200_Y214_E0.5800.84
120_P124_R0.5770.84
147_L185_R0.5760.84
147_L190_Y0.5760.84
260_A263_D0.5760.84
319_F322_Y0.5750.84
56_R275_G0.5730.83
225_A229_A0.5710.83
41_C189_F0.5700.83
254_R260_A0.5700.83
182_I208_L0.5700.83
196_C200_Y0.5690.83
245_L273_L0.5690.83
75_D79_T0.5690.83
53_L317_A0.5670.83
218_M221_V0.5670.83
215_A231_L0.5660.83
228_A232_D0.5660.83
239_A242_P0.5650.82
156_H207_F0.5650.82
9_C47_S0.5640.82
187_R221_V0.5640.82
312_G316_L0.5640.82
16_N34_L0.5630.82
22_L27_D0.5600.82
144_L163_L0.5600.82
222_L226_E0.5590.82
27_D30_P0.5590.82
316_L320_A0.5580.82
124_R128_N0.5570.82
137_A181_L0.5570.82
55_V169_Y0.5550.81
90_L98_F0.5550.81
91_R138_E0.5550.81
42_F311_E0.5540.81
126_A173_A0.5540.81
292_A295_D0.5530.81
3_A7_L0.5490.81
151_I205_E0.5490.81
246_L273_L0.5490.81
263_D312_G0.5490.81
238_L290_L0.5480.81
107_L136_I0.5480.81
259_L263_D0.5480.81
205_E257_G0.5470.80
226_E229_A0.5450.80
55_V59_R0.5440.80
198_A242_P0.5440.80
298_L301_G0.5430.80
101_P165_L0.5410.80
96_A257_G0.5410.80
25_D33_E0.5400.80
267_L301_G0.5400.80
12_R313_E0.5390.79
195_D200_Y0.5380.79
151_I203_S0.5380.79
105_A165_L0.5380.79
109_K318_S0.5380.79
153_V158_N0.5370.79
239_A245_L0.5360.79
301_G321_V0.5350.79
167_L220_R0.5350.79
100_R262_L0.5330.79
315_W319_F0.5320.79
226_E233_A0.5310.78
23_N28_V0.5300.78
198_A273_L0.5280.78
165_L208_L0.5250.78
32_R39_Y0.5240.78
161_F208_L0.5230.77
163_L186_A0.5230.77
268_S272_C0.5230.77
218_M222_L0.5220.77
87_V128_N0.5220.77
162_A165_L0.5220.77
286_R289_A0.5220.77
47_S74_L0.5210.77
104_W158_N0.5210.77
108_L133_A0.5200.77
37_A85_A0.5200.77
118_D127_A0.5200.77
88_A92_R0.5180.77
240_A243_A0.5170.77
72_A291_L0.5170.77
108_L169_Y0.5170.77
87_V137_A0.5170.77
254_R304_H0.5150.76
13_E18_L0.5130.76
23_N27_D0.5130.76
267_L298_L0.5130.76
37_A128_N0.5120.76
97_S258_K0.5120.76
74_L78_L0.5080.75
308_G317_A0.5070.75
143_W159_T0.5070.75
30_P35_H0.5060.75
112_A116_E0.5060.75
153_V196_C0.5060.75
5_L53_L0.5050.75
29_R34_L0.5030.75
140_L165_L0.5030.75
74_L169_Y0.5020.74
198_A231_L0.5010.74
84_A91_R0.5010.74
46_S49_H0.5000.74
146_K259_L0.5000.74
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4mu9A 1 0.6254 62.1 0.964 Contact Map
2ahfA 1 0.582 58.1 0.965 Contact Map
3k7xA 1 0.7926 56.8 0.965 Contact Map
4wu0A 1 0.5449 54 0.966 Contact Map
4v1sA 1 0.6656 32.8 0.97 Contact Map
3vw5A 1 0.8142 31.5 0.97 Contact Map
4c1sA 1 0.9381 30.9 0.97 Contact Map
1nc5A 1 0.548 27.8 0.971 Contact Map
5agdA 1 0.6099 26 0.972 Contact Map
4p40A 1 0.2229 20.6 0.973 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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