DUF2891 - PFAM28P - GREMLIN Contacts

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DUF2891 - Protein of unknown function (DUF2891)

PFAM:	PF11199	Sequences: RFARLALACVHREYPNKLDHVLNSDADVRPPRELHPAFYGCFDWHSSVHGHWLLVRLLRLFPDLPEAAEIRAALDASLTAENIAAEVAYLRRPGRASFERPYGWAWLLKLAAELREWDDPDARRWAANLQPLADAIAERLLDWLPKLTYPIRVGEHSNTAFALGLALDYARAAGDAALAALIRERARRFYLNDRDCPAAYEPSGEDFLSPCLAEADLMRRVLPPAEFAAWLDAFLPGLAAGPATLLEPAVVSDRSDGKLAHLDGLNLSRAWCLRGIAAALPAGDPRRAALLAAADAHLAAGLPHVTGGDYEGEHWLASFAVYA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	323 (322)
Sequences:	4703 (3035)
Seq/√Len:	169.1
META:	0.888

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
185_R	188_R	5.105	1.00
196_C	211_C	3.793	1.00
205_E	258_K	3.081	1.00
171_R	179_A	2.897	1.00
130_Q	134_D	2.675	1.00
194_R	233_A	2.655	1.00
179_A	183_R	2.622	1.00
67_A	71_R	2.607	1.00
37_A	83_I	2.541	1.00
187_R	191_L	2.518	1.00
216_D	219_R	2.482	1.00
92_R	95_R	2.474	1.00
29_R	33_E	2.466	1.00
167_L	179_A	2.435	1.00
167_L	171_R	2.432	1.00
121_D	124_R	2.392	1.00
287_R	291_L	2.350	1.00
184_E	188_R	2.331	1.00
141_L	175_D	2.303	1.00
75_D	124_R	2.284	1.00
223_P	226_E	2.189	1.00
140_L	166_A	2.178	1.00
167_L	183_R	2.154	1.00
155_E	258_K	2.148	1.00
83_I	87_V	2.135	1.00
183_R	187_R	2.118	1.00
71_R	121_D	2.082	1.00
11_H	77_S	2.078	1.00
55_V	74_L	2.059	1.00
135_A	139_R	2.050	1.00
171_R	183_R	2.035	1.00
187_R	226_E	2.010	1.00
23_N	94_G	2.005	1.00
163_L	182_I	1.998	1.00
59_R	116_E	1.970	1.00
308_G	313_E	1.957	1.00
148_T	252_S	1.950	1.00
25_D	30_P	1.938	1.00
273_L	290_L	1.935	1.00
295_D	299_A	1.934	1.00
75_D	125_W	1.924	1.00
186_A	218_M	1.921	1.00
219_R	275_G	1.897	1.00
13_E	32_R	1.893	1.00
137_A	175_D	1.879	1.00
168_D	220_R	1.872	1.00
87_V	135_A	1.865	1.00
4_R	69_E	1.855	1.00
115_R	126_A	1.839	1.00
254_R	263_D	1.835	1.00
214_E	234_F	1.834	1.00
11_H	76_A	1.791	1.00
71_R	119_D	1.774	1.00
216_D	275_G	1.767	1.00
195_D	237_G	1.753	1.00
112_A	172_A	1.747	1.00
117_W	122_A	1.737	1.00
140_L	162_A	1.735	1.00
80_A	128_N	1.728	1.00
20_H	89_Y	1.719	1.00
91_R	135_A	1.715	1.00
115_R	173_A	1.710	1.00
37_A	82_N	1.702	1.00
138_E	142_D	1.693	1.00
14_Y	30_P	1.664	1.00
75_D	121_D	1.658	1.00
30_P	33_E	1.656	1.00
118_D	123_R	1.620	1.00
111_A	126_A	1.590	1.00
109_K	112_A	1.582	1.00
21_V	42_F	1.574	1.00
249_A	266_N	1.560	1.00
8_A	12_R	1.560	1.00
153_V	157_S	1.554	1.00
111_A	133_A	1.546	1.00
137_A	178_L	1.542	1.00
185_R	189_F	1.541	1.00
148_T	250_V	1.523	1.00
59_R	113_E	1.507	1.00
78_L	128_N	1.501	1.00
166_A	178_L	1.499	1.00
141_L	181_L	1.498	1.00
18_L	34_L	1.494	1.00
307_G	313_E	1.486	1.00
4_R	66_E	1.471	1.00
180_A	184_E	1.465	1.00
78_L	125_W	1.456	1.00
181_L	185_R	1.427	1.00
55_V	58_L	1.415	1.00
53_L	321_V	1.410	1.00
73_A	77_S	1.409	1.00
79_T	82_N	1.402	1.00
227_F	276_I	1.397	1.00
176_A	179_A	1.380	1.00
111_A	115_R	1.375	1.00
58_L	71_R	1.370	1.00
17_K	21_V	1.360	1.00
121_D	125_W	1.360	1.00
178_L	182_I	1.356	1.00
164_G	220_R	1.353	1.00
13_E	16_N	1.346	1.00
90_L	136_I	1.337	1.00
115_R	133_A	1.322	1.00
252_S	259_L	1.321	1.00
141_L	177_A	1.312	1.00
37_A	77_S	1.312	1.00
109_K	165_L	1.302	1.00
37_A	78_L	1.280	1.00
66_E	69_E	1.278	1.00
25_D	32_R	1.277	1.00
9_C	41_C	1.266	1.00
42_F	257_G	1.262	1.00
164_G	216_D	1.259	1.00
219_R	279_A	1.250	1.00
135_A	138_E	1.233	1.00
227_F	231_L	1.230	1.00
4_R	8_A	1.229	1.00
20_H	34_L	1.229	1.00
24_S	27_D	1.223	1.00
58_L	67_A	1.221	1.00
59_R	117_W	1.214	1.00
10_V	54_L	1.211	1.00
137_A	141_L	1.205	1.00
141_L	178_L	1.204	1.00
55_V	114_L	1.198	1.00
97_S	257_G	1.194	1.00
276_I	280_L	1.190	1.00
80_A	84_A	1.187	1.00
56_R	60_L	1.185	1.00
191_L	222_L	1.183	1.00
14_Y	25_D	1.183	1.00
2_F	6_A	1.175	1.00
182_I	217_L	1.172	1.00
203_S	206_D	1.172	1.00
257_G	311_E	1.159	1.00
84_A	88_A	1.159	1.00
23_N	92_R	1.153	1.00
133_A	137_A	1.150	1.00
193_D	214_E	1.140	1.00
54_L	70_I	1.133	1.00
231_L	238_L	1.116	1.00
155_E	205_E	1.106	1.00
51_H	74_L	1.100	1.00
116_E	172_A	1.087	1.00
115_R	130_Q	1.087	1.00
213_A	272_C	1.078	1.00
69_E	72_A	1.076	1.00
79_T	128_N	1.066	1.00
14_Y	22_L	1.055	0.99
56_R	113_E	1.052	0.99
145_P	181_L	1.051	0.99
166_A	182_I	1.051	0.99
208_L	213_A	1.044	0.99
90_L	135_A	1.040	0.99
186_A	217_L	1.039	0.99
274_R	295_D	1.036	0.99
292_A	296_A	1.029	0.99
84_A	87_V	1.025	0.99
85_A	88_A	1.025	0.99
115_R	172_A	1.023	0.99
96_A	142_D	1.021	0.99
10_V	73_A	1.018	0.99
11_H	73_A	1.010	0.99
190_Y	214_E	1.001	0.99
111_A	169_Y	0.998	0.99
76_A	82_N	0.993	0.99
232_D	284_D	0.993	0.99
277_A	291_L	0.990	0.99
22_L	28_V	0.989	0.99
215_A	276_I	0.985	0.99
5_L	50_G	0.983	0.99
196_C	234_F	0.978	0.99
87_V	91_R	0.978	0.99
274_R	298_L	0.974	0.99
127_A	130_Q	0.972	0.99
57_L	64_L	0.970	0.99
146_K	253_D	0.958	0.99
66_E	70_I	0.957	0.99
16_N	39_Y	0.948	0.99
37_A	51_H	0.947	0.99
176_A	180_A	0.941	0.99
275_G	278_A	0.939	0.99
211_C	235_L	0.938	0.99
197_P	200_Y	0.938	0.99
255_S	309_D	0.933	0.99
20_H	28_V	0.933	0.99
64_L	70_I	0.930	0.99
3_A	57_L	0.928	0.99
41_C	47_S	0.926	0.99
6_A	53_L	0.921	0.99
96_A	146_K	0.919	0.99
3_A	54_L	0.917	0.99
104_W	136_I	0.912	0.98
83_I	128_N	0.912	0.98
78_L	83_I	0.902	0.98
198_A	245_L	0.900	0.98
266_N	297_H	0.900	0.98
142_D	146_K	0.895	0.98
134_D	175_D	0.893	0.98
18_L	22_L	0.893	0.98
5_L	306_T	0.889	0.98
43_D	46_S	0.888	0.98
53_L	57_L	0.883	0.98
147_L	189_F	0.875	0.98
101_P	157_S	0.869	0.98
167_L	182_I	0.869	0.98
37_A	79_T	0.867	0.98
5_L	9_C	0.864	0.98
109_K	168_D	0.864	0.98
129_L	133_A	0.862	0.98
143_W	147_L	0.861	0.98
167_L	217_L	0.860	0.98
47_S	51_H	0.859	0.98
72_A	76_A	0.857	0.98
77_S	82_N	0.856	0.98
148_T	249_A	0.854	0.98
157_S	205_E	0.854	0.98
11_H	39_Y	0.853	0.98
224_P	279_A	0.851	0.98
123_R	126_A	0.851	0.98
23_N	95_R	0.848	0.98
247_E	250_V	0.848	0.98
169_Y	178_L	0.839	0.97
260_A	307_G	0.839	0.97
242_P	246_L	0.839	0.97
149_Y	249_A	0.837	0.97
216_D	220_R	0.828	0.97
288_A	292_A	0.822	0.97
152_R	193_D	0.821	0.97
281_P	287_R	0.820	0.97
247_E	296_A	0.813	0.97
224_P	228_A	0.812	0.97
167_L	221_V	0.810	0.97
107_L	129_L	0.809	0.97
180_A	183_R	0.807	0.97
301_G	304_H	0.803	0.97
101_P	144_L	0.800	0.97
19_D	42_F	0.790	0.96
119_D	122_A	0.789	0.96
229_A	232_D	0.788	0.96
228_A	281_P	0.788	0.96
88_A	91_R	0.787	0.96
109_K	116_E	0.787	0.96
13_E	34_L	0.785	0.96
35_H	89_Y	0.784	0.96
153_V	203_S	0.778	0.96
195_D	199_A	0.777	0.96
241_G	289_A	0.776	0.96
151_I	163_L	0.775	0.96
9_C	50_G	0.765	0.96
159_T	189_F	0.763	0.95
198_A	244_T	0.761	0.95
317_A	322_Y	0.759	0.95
237_G	240_A	0.755	0.95
148_T	259_L	0.755	0.95
277_A	294_A	0.754	0.95
153_V	205_E	0.754	0.95
104_W	140_L	0.752	0.95
182_I	186_A	0.752	0.95
3_A	70_I	0.751	0.95
39_Y	77_S	0.750	0.95
83_I	129_L	0.748	0.95
169_Y	173_A	0.748	0.95
134_D	138_E	0.747	0.95
313_E	317_A	0.745	0.95
187_R	222_L	0.742	0.95
296_A	299_A	0.740	0.95
122_A	126_A	0.734	0.94
158_N	213_A	0.730	0.94
232_D	286_R	0.730	0.94
17_K	42_F	0.730	0.94
149_Y	254_R	0.729	0.94
306_T	313_E	0.727	0.94
101_P	143_W	0.726	0.94
53_L	56_R	0.716	0.94
114_L	129_L	0.715	0.94
1_R	4_R	0.714	0.94
215_A	280_L	0.710	0.93
73_A	76_A	0.707	0.93
273_L	293_A	0.707	0.93
20_H	95_R	0.706	0.93
89_Y	95_R	0.706	0.93
245_L	293_A	0.705	0.93
147_L	159_T	0.703	0.93
34_L	89_Y	0.703	0.93
239_A	289_A	0.702	0.93
159_T	190_Y	0.702	0.93
71_R	75_D	0.697	0.93
191_L	218_M	0.697	0.93
58_L	117_W	0.696	0.93
112_A	165_L	0.695	0.93
122_A	125_W	0.695	0.93
6_A	10_V	0.691	0.92
298_L	302_L	0.690	0.92
152_R	214_E	0.690	0.92
164_G	213_A	0.685	0.92
190_Y	204_G	0.685	0.92
108_L	136_I	0.685	0.92
17_K	20_H	0.683	0.92
10_V	55_V	0.683	0.92
299_A	303_P	0.683	0.92
72_A	75_D	0.682	0.92
101_P	151_I	0.676	0.92
229_A	233_A	0.676	0.92
57_L	66_E	0.676	0.92
186_A	221_V	0.675	0.92
68_A	72_A	0.671	0.91
238_L	246_L	0.671	0.91
242_P	245_L	0.670	0.91
177_A	180_A	0.664	0.91
305_V	313_E	0.658	0.90
18_L	27_D	0.658	0.90
208_L	268_S	0.653	0.90
2_F	53_L	0.652	0.90
171_R	220_R	0.650	0.90
211_C	234_F	0.650	0.90
81_E	84_A	0.648	0.90
100_R	104_W	0.646	0.90
305_V	309_D	0.646	0.90
69_E	73_A	0.645	0.90
130_Q	133_A	0.644	0.89
3_A	66_E	0.640	0.89
126_A	133_A	0.640	0.89
304_H	307_G	0.639	0.89
51_H	73_A	0.636	0.89
105_A	162_A	0.632	0.89
283_G	287_R	0.631	0.89
291_L	295_D	0.625	0.88
49_H	318_S	0.624	0.88
108_L	166_A	0.623	0.88
170_A	179_A	0.623	0.88
195_D	233_A	0.623	0.88
238_L	289_A	0.621	0.88
289_A	293_A	0.621	0.88
164_G	219_R	0.619	0.88
55_V	117_W	0.619	0.88
53_L	318_S	0.619	0.88
151_I	258_K	0.619	0.88
51_H	56_R	0.619	0.88
249_A	262_L	0.618	0.88
125_W	128_N	0.618	0.88
49_H	319_F	0.617	0.87
109_K	169_Y	0.617	0.87
14_Y	24_S	0.616	0.87
101_P	105_A	0.616	0.87
232_D	239_A	0.614	0.87
272_C	275_G	0.613	0.87
143_W	205_E	0.613	0.87
80_A	127_A	0.612	0.87
16_N	31_P	0.611	0.87
87_V	132_L	0.610	0.87
164_G	208_L	0.609	0.87
5_L	8_A	0.607	0.87
213_A	216_D	0.606	0.86
260_A	311_E	0.605	0.86
157_S	203_S	0.605	0.86
20_H	27_D	0.605	0.86
16_N	19_D	0.603	0.86
89_Y	98_F	0.598	0.86
268_S	271_W	0.595	0.85
216_D	272_C	0.594	0.85
13_E	30_P	0.594	0.85
296_A	300_A	0.591	0.85
19_D	22_L	0.589	0.85
198_A	246_L	0.589	0.85
112_A	115_R	0.589	0.85
8_A	313_E	0.589	0.85
57_L	321_V	0.588	0.85
278_A	291_L	0.588	0.85
272_C	276_I	0.587	0.85
6_A	9_C	0.585	0.85
64_L	67_A	0.585	0.85
284_D	287_R	0.585	0.85
160_A	190_Y	0.585	0.85
78_L	82_N	0.581	0.84
274_R	294_A	0.581	0.84
140_L	145_P	0.581	0.84
200_Y	214_E	0.580	0.84
120_P	124_R	0.577	0.84
147_L	185_R	0.576	0.84
147_L	190_Y	0.576	0.84
260_A	263_D	0.576	0.84
319_F	322_Y	0.575	0.84
56_R	275_G	0.573	0.83
225_A	229_A	0.571	0.83
41_C	189_F	0.570	0.83
254_R	260_A	0.570	0.83
182_I	208_L	0.570	0.83
196_C	200_Y	0.569	0.83
245_L	273_L	0.569	0.83
75_D	79_T	0.569	0.83
53_L	317_A	0.567	0.83
218_M	221_V	0.567	0.83
215_A	231_L	0.566	0.83
228_A	232_D	0.566	0.83
239_A	242_P	0.565	0.82
156_H	207_F	0.565	0.82
9_C	47_S	0.564	0.82
187_R	221_V	0.564	0.82
312_G	316_L	0.564	0.82
16_N	34_L	0.563	0.82
22_L	27_D	0.560	0.82
144_L	163_L	0.560	0.82
222_L	226_E	0.559	0.82
27_D	30_P	0.559	0.82
316_L	320_A	0.558	0.82
124_R	128_N	0.557	0.82
137_A	181_L	0.557	0.82
55_V	169_Y	0.555	0.81
90_L	98_F	0.555	0.81
91_R	138_E	0.555	0.81
42_F	311_E	0.554	0.81
126_A	173_A	0.554	0.81
292_A	295_D	0.553	0.81
3_A	7_L	0.549	0.81
151_I	205_E	0.549	0.81
246_L	273_L	0.549	0.81
263_D	312_G	0.549	0.81
238_L	290_L	0.548	0.81
107_L	136_I	0.548	0.81
259_L	263_D	0.548	0.81
205_E	257_G	0.547	0.80
226_E	229_A	0.545	0.80
55_V	59_R	0.544	0.80
198_A	242_P	0.544	0.80
298_L	301_G	0.543	0.80
101_P	165_L	0.541	0.80
96_A	257_G	0.541	0.80
25_D	33_E	0.540	0.80
267_L	301_G	0.540	0.80
12_R	313_E	0.539	0.79
195_D	200_Y	0.538	0.79
151_I	203_S	0.538	0.79
105_A	165_L	0.538	0.79
109_K	318_S	0.538	0.79
153_V	158_N	0.537	0.79
239_A	245_L	0.536	0.79
301_G	321_V	0.535	0.79
167_L	220_R	0.535	0.79
100_R	262_L	0.533	0.79
315_W	319_F	0.532	0.79
226_E	233_A	0.531	0.78
23_N	28_V	0.530	0.78
198_A	273_L	0.528	0.78
165_L	208_L	0.525	0.78
32_R	39_Y	0.524	0.78
161_F	208_L	0.523	0.77
163_L	186_A	0.523	0.77
268_S	272_C	0.523	0.77
218_M	222_L	0.522	0.77
87_V	128_N	0.522	0.77
162_A	165_L	0.522	0.77
286_R	289_A	0.522	0.77
47_S	74_L	0.521	0.77
104_W	158_N	0.521	0.77
108_L	133_A	0.520	0.77
37_A	85_A	0.520	0.77
118_D	127_A	0.520	0.77
88_A	92_R	0.518	0.77
240_A	243_A	0.517	0.77
72_A	291_L	0.517	0.77
108_L	169_Y	0.517	0.77
87_V	137_A	0.517	0.77
254_R	304_H	0.515	0.76
13_E	18_L	0.513	0.76
23_N	27_D	0.513	0.76
267_L	298_L	0.513	0.76
37_A	128_N	0.512	0.76
97_S	258_K	0.512	0.76
74_L	78_L	0.508	0.75
308_G	317_A	0.507	0.75
143_W	159_T	0.507	0.75
30_P	35_H	0.506	0.75
112_A	116_E	0.506	0.75
153_V	196_C	0.506	0.75
5_L	53_L	0.505	0.75
29_R	34_L	0.503	0.75
140_L	165_L	0.503	0.75
74_L	169_Y	0.502	0.74
198_A	231_L	0.501	0.74
84_A	91_R	0.501	0.74
46_S	49_H	0.500	0.74
146_K	259_L	0.500	0.74

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4mu9A	1	0.6254	62.1	0.964	Contact Map
2ahfA	1	0.582	58.1	0.965	Contact Map
3k7xA	1	0.7926	56.8	0.965	Contact Map
4wu0A	1	0.5449	54	0.966	Contact Map
4v1sA	1	0.6656	32.8	0.97	Contact Map
3vw5A	1	0.8142	31.5	0.97	Contact Map
4c1sA	1	0.9381	30.9	0.97	Contact Map
1nc5A	1	0.548	27.8	0.971	Contact Map
5agdA	1	0.6099	26	0.972	Contact Map
4p40A	1	0.2229	20.6	0.973	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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