GREMLIN Database
DUF2835 - Protein of unknown function (DUF2835)
PFAM: PF11197 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 68 (67)
Sequences: 1660 (1254)
Seq/√Len: 153.2
META: 0.804

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
28_R52_R2.9591.00
6_N50_H2.5521.00
54_R67_E2.4481.00
4_S28_R2.2901.00
24_V32_R2.2201.00
39_H63_F2.1711.00
22_S34_Q2.1041.00
3_F25_V2.0561.00
24_V34_Q1.9701.00
35_F40_L1.9321.00
27_A31_R1.9031.00
12_Y44_V1.8651.00
26_R32_R1.7071.00
47_D50_H1.6171.00
11_E14_R1.5871.00
13_L17_Q1.5201.00
2_R54_R1.5031.00
4_S52_R1.4451.00
56_T67_E1.4151.00
15_Y37_A1.4071.00
56_T65_S1.3791.00
38_S41_R1.3331.00
12_Y37_A1.3321.00
23_V40_L1.2841.00
14_R19_A1.2141.00
57_F61_N1.1951.00
3_F66_L1.1841.00
8_S11_E1.1651.00
2_R28_R1.1461.00
58_D64_V1.1181.00
63_F66_L1.1010.99
35_F55_L1.0830.99
7_I12_Y1.0770.99
5_L40_L0.9920.99
58_D62_K0.9860.99
30_G40_L0.9780.99
43_F66_L0.9410.98
55_L66_L0.9380.98
22_S35_F0.9200.98
2_R52_R0.9090.98
9_A13_L0.9090.98
57_F63_F0.8980.98
39_H66_L0.8500.97
36_P62_K0.8460.97
36_P39_H0.8410.96
39_H55_L0.8240.96
9_A12_Y0.8190.96
36_P57_F0.7930.95
26_R42_P0.7830.95
39_H43_F0.7770.95
37_A41_R0.7700.94
20_A32_R0.7630.94
3_F15_Y0.7560.94
5_L35_F0.7510.94
14_R17_Q0.7500.93
25_V35_F0.7360.93
39_H57_F0.7320.93
12_Y40_L0.7260.92
21_R38_S0.7080.91
12_Y49_I0.7040.91
9_A44_V0.6840.90
41_R44_V0.6750.89
10_E13_L0.6710.89
29_D57_F0.6670.89
6_N47_D0.6590.88
17_Q41_R0.6570.88
9_A46_H0.6540.88
31_R46_H0.6340.86
56_T64_V0.6290.86
40_L55_L0.6280.86
14_R20_A0.6260.85
18_G41_R0.6260.85
35_F49_I0.6160.85
18_G37_A0.6080.84
38_S62_K0.6050.83
23_V49_I0.5990.83
30_G42_P0.5940.82
15_Y43_F0.5900.82
23_V37_A0.5890.82
7_I11_E0.5830.81
25_V28_R0.5770.81
14_R27_A0.5750.80
58_D61_N0.5710.80
36_P63_F0.5710.80
39_H62_K0.5580.78
7_I21_R0.5560.78
18_G21_R0.5490.77
57_F62_K0.5400.76
23_V35_F0.5350.75
4_S46_H0.5300.75
15_Y44_V0.5300.75
45_T56_T0.5260.74
13_L41_R0.5250.74
34_Q62_K0.5230.74
26_R67_E0.5190.73
20_A37_A0.5160.73
31_R57_F0.5140.72
43_F53_F0.5070.71
21_R41_R0.5030.71
17_Q44_V0.5000.70
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2do3A 1 0.5735 36.4 0.864 Contact Map
1wp5A 1 0.9706 26.4 0.874 Contact Map
3l6vA 1 0.9706 25.1 0.875 Contact Map
1zi0A 1 0.9559 23.2 0.877 Contact Map
1zvtA 1 0.9412 19.7 0.881 Contact Map
4g3nA 1 0.9706 17.6 0.884 Contact Map
1suuA 1 0.9559 15.4 0.886 Contact Map
3no0A 1 0.9559 13.1 0.89 Contact Map
1zvuA 2 0.9559 12.7 0.89 Contact Map
4lx3A 1 0.8382 11.6 0.892 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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