GREMLIN Database
DUF2834 - Protein of unknown function (DUF2834)
PFAM: PF11196 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 96 (95)
Sequences: 5619 (3800)
Seq/√Len: 389.9
META: 0.912

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
52_A78_T2.6221.00
36_F42_A2.3641.00
3_L92_Y2.2851.00
62_E90_F2.2591.00
74_Y93_L2.2401.00
17_F43_F2.2011.00
1_L57_V2.1871.00
35_L44_F2.1131.00
63_G71_L2.0331.00
29_P33_A1.9491.00
1_L5_L1.9101.00
6_A85_F1.8821.00
10_L85_F1.8271.00
30_L34_A1.8221.00
52_A56_L1.6901.00
56_L78_T1.6711.00
38_N41_S1.6431.00
12_L46_L1.6281.00
8_L12_L1.6141.00
27_D30_L1.5641.00
77_A85_F1.5621.00
55_L59_M1.5271.00
51_S83_V1.5131.00
18_V22_A1.4991.00
78_T86_G1.4891.00
56_L60_V1.4881.00
36_F46_L1.4461.00
55_L83_V1.4171.00
15_Y19_P1.3481.00
35_L45_G1.3251.00
62_E94_R1.3081.00
81_V85_F1.2891.00
9_G13_P1.2541.00
5_L54_V1.2191.00
36_F45_G1.2081.00
16_F39_P1.2011.00
20_F24_H1.1921.00
37_A41_S1.1841.00
49_L53_V1.1561.00
59_M74_Y1.1461.00
10_L14_Y1.1241.00
30_L33_A1.1201.00
56_L75_I1.1181.00
56_L79_L1.0501.00
68_M90_F1.0391.00
41_S45_G1.0221.00
20_F34_A1.0221.00
34_A38_N1.0001.00
55_L87_L0.9911.00
57_V61_V0.9901.00
89_L93_L0.9871.00
42_A46_L0.9671.00
19_P39_P0.9651.00
60_V75_I0.9611.00
61_V65_R0.9601.00
51_S55_L0.9561.00
14_Y17_F0.9521.00
58_F62_E0.9361.00
35_L41_S0.9331.00
24_H27_D0.9271.00
62_E66_L0.9241.00
75_I79_L0.9021.00
69_R72_W0.8931.00
70_R73_L0.8911.00
16_F19_P0.8821.00
68_M93_L0.8771.00
71_L74_Y0.8731.00
15_Y18_V0.8521.00
60_V64_R0.8491.00
2_Y91_L0.8411.00
83_V86_G0.8291.00
19_P22_A0.8171.00
68_M72_W0.7951.00
74_Y77_A0.7911.00
77_A86_G0.7841.00
31_F40_A0.7771.00
74_Y86_G0.7651.00
54_V88_P0.7651.00
51_S87_L0.7641.00
50_V84_S0.7621.00
16_F46_L0.7411.00
76_V80_L0.7381.00
64_R70_R0.7291.00
81_V84_S0.7241.00
12_L50_V0.7221.00
51_S54_V0.7211.00
63_G68_M0.7121.00
6_A92_Y0.7101.00
44_F48_L0.7061.00
64_R67_G0.7051.00
39_P42_A0.7051.00
20_F40_A0.6961.00
34_A37_A0.6920.99
29_P32_F0.6900.99
28_L32_F0.6900.99
13_P17_F0.6880.99
46_L49_L0.6880.99
84_S88_P0.6870.99
65_R95_E0.6860.99
82_G88_P0.6810.99
59_M71_L0.6760.99
19_P23_E0.6760.99
60_V71_L0.6750.99
21_L24_H0.6700.99
63_G90_F0.6540.99
26_L30_L0.6520.99
19_P24_H0.6500.99
68_M74_Y0.6470.99
20_F25_G0.6430.99
43_F82_G0.6420.99
3_L7_V0.6400.99
77_A89_L0.6350.99
5_L53_V0.6270.99
85_F89_L0.6250.99
49_L52_A0.6200.99
57_V60_V0.6150.99
73_L77_A0.6120.99
14_Y18_V0.6110.99
62_E68_M0.6080.99
42_A45_G0.6070.99
45_G49_L0.6020.99
84_S87_L0.5970.99
21_L25_G0.5880.98
59_M75_I0.5810.98
65_R69_R0.5810.98
2_Y95_E0.5810.98
6_A10_L0.5780.98
9_G50_V0.5750.98
31_F35_L0.5700.98
86_G93_L0.5690.98
83_V87_L0.5560.98
35_L40_A0.5550.98
5_L9_G0.5510.97
14_Y80_L0.5360.97
34_A39_P0.5360.97
71_L76_V0.5300.97
62_E65_R0.5200.96
12_L16_F0.5190.96
13_P20_F0.5190.96
68_M71_L0.5180.96
5_L50_V0.5160.96
65_R68_M0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3j8eG 3 0.8854 6.1 0.9 Contact Map
4nv5A 1 0.9271 5.5 0.902 Contact Map
1iijA 1 0.3646 5.4 0.902 Contact Map
4px7A 1 0.9375 4.4 0.906 Contact Map
2m20A 2 0.3125 3.2 0.913 Contact Map
1rzhM 1 0.9583 3.1 0.913 Contact Map
4fbzA 3 0.6458 3 0.914 Contact Map
4aw6A 2 0.8958 2.5 0.917 Contact Map
1eysM 1 0.9583 2.4 0.918 Contact Map
4jq6A 3 0.5833 2.1 0.921 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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