GREMLIN Database
DUF2829 - Protein of unknown function (DUF2829)
PFAM: PF11195 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 72 (70)
Sequences: 4401 (3641)
Seq/√Len: 435.1
META: 0.911

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
16_A70_E3.0791.00
8_A13_K2.5461.00
4_E8_A2.3751.00
1_N7_E2.1931.00
18_K70_E2.1511.00
10_K67_E2.1411.00
9_L15_V1.9881.00
47_K51_G1.9851.00
5_A15_V1.8301.00
2_F64_M1.8271.00
4_E7_E1.8031.00
41_L52_K1.7681.00
30_Q45_D1.6651.00
8_A71_I1.5661.00
27_L44_I1.5241.00
1_N4_E1.5171.00
3_G7_E1.4971.00
29_L65_L1.4861.00
2_F6_L1.4301.00
28_F45_D1.4231.00
59_A64_M1.4211.00
8_A11_A1.4111.00
3_G6_L1.3101.00
44_I59_A1.2641.00
40_Y45_D1.2321.00
47_K53_I1.2291.00
9_L44_I1.1841.00
34_D37_S1.1731.00
17_R66_A1.1681.00
7_E11_A1.1531.00
28_F53_I1.1501.00
8_A15_V1.1451.00
30_Q33_S1.1171.00
4_E11_A1.1151.00
17_R68_D1.1141.00
25_M46_M1.1021.00
40_Y43_Y1.1001.00
45_D53_I1.0891.00
43_Y56_P1.0521.00
15_V27_L1.0431.00
13_K71_I0.9621.00
14_K26_F0.9591.00
41_L62_T0.9531.00
30_Q43_Y0.9491.00
61_Q64_M0.9471.00
3_G10_K0.9051.00
33_S40_Y0.8831.00
34_D38_K0.8791.00
14_K28_F0.8761.00
48_T55_V0.8511.00
39_M52_K0.8411.00
21_N25_M0.8181.00
26_F47_K0.8061.00
6_L64_M0.7631.00
58_L61_Q0.7601.00
33_S45_D0.7571.00
41_L48_T0.7551.00
9_L29_L0.7351.00
28_F33_S0.7151.00
48_T62_T0.7091.00
33_S37_S0.6941.00
22_G25_M0.6921.00
55_V62_T0.6901.00
48_T52_K0.6861.00
44_I64_M0.6721.00
44_I65_L0.6701.00
40_Y53_I0.6641.00
56_P61_Q0.6591.00
33_S43_Y0.6510.99
15_V71_I0.6490.99
4_E71_I0.6480.99
6_L9_L0.6470.99
6_L65_L0.6470.99
4_E70_E0.6450.99
32_G42_P0.6420.99
28_F38_K0.6390.99
25_M49_A0.6370.99
45_D56_P0.6360.99
35_G38_K0.6290.99
58_L62_T0.6220.99
33_S39_M0.5970.99
28_F40_Y0.5860.99
2_F59_A0.5820.99
49_A53_I0.5800.99
58_L64_M0.5760.99
6_L10_K0.5760.99
59_A62_T0.5740.99
38_K53_I0.5710.99
3_G65_L0.5710.99
41_L55_V0.5680.99
30_Q39_M0.5570.98
35_G40_Y0.5540.98
25_M62_T0.5490.98
57_W61_Q0.5430.98
57_W63_D0.5330.98
31_P37_S0.5320.98
3_G9_L0.5280.98
21_N24_G0.5260.98
30_Q40_Y0.5240.98
55_V61_Q0.5230.98
38_K45_D0.5220.98
39_M45_D0.5140.97
34_D40_Y0.5050.97
19_G25_M0.5040.97
46_M49_A0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3nrlA 2 0.75 12.6 0.853 Contact Map
2owlA 2 0.9167 9 0.862 Contact Map
5aj3j 1 0.9861 8.6 0.864 Contact Map
2owyA 2 0.9167 8.6 0.864 Contact Map
2y0nA 2 0.2917 7.8 0.867 Contact Map
2f5jA 2 0.2778 5.8 0.874 Contact Map
2vkjA 2 0.5417 4.3 0.881 Contact Map
2xtzA 1 0.9861 4.2 0.882 Contact Map
4gkvA 4 0.3333 3.7 0.886 Contact Map
2anuA 5 0.3056 3.6 0.886 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0047 seconds.