GREMLIN Database
DUF2812 - Protein of unknown function (DUF2812)
PFAM: PF11193 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 110 (103)
Sequences: 3538 (2792)
Seq/√Len: 275.1
META: 0.774

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
20_K30_E4.3051.00
18_H32_G3.8311.00
65_E77_R2.7141.00
14_A36_E2.3431.00
6_E40_R2.2191.00
35_G79_E2.1801.00
8_W29_F2.1501.00
13_A18_H2.1481.00
37_Y77_R2.1371.00
12_M15_K1.9531.00
17_W31_K1.9361.00
38_I80_A1.9091.00
59_F76_F1.8281.00
5_E27_Y1.7601.00
42_D55_Y1.7581.00
10_N36_E1.7501.00
66_Y74_Q1.7401.00
59_F87_I1.6931.00
13_A37_Y1.6921.00
21_K28_T1.5721.00
57_E61_D1.4701.00
5_E75_Y1.4691.00
36_E79_E1.4251.00
88_Y93_S1.4031.00
69_S74_Q1.3671.00
66_Y69_S1.3571.00
60_E65_E1.3491.00
42_D88_Y1.3361.00
12_M29_F1.3211.00
59_F64_W1.2971.00
51_E54_E1.2891.00
40_R86_E1.2721.00
56_L66_Y1.2571.00
13_A32_G1.2401.00
19_L75_Y1.2301.00
11_E15_K1.2271.00
18_H35_G1.2161.00
8_W12_M1.1971.00
78_K82_D1.1941.00
56_L76_F1.1911.00
19_L22_V1.1531.00
37_Y79_E1.1461.00
18_H77_R1.1421.00
57_E60_E1.1411.00
18_H39_Y1.1161.00
20_K28_T1.1141.00
7_K11_E1.1111.00
10_N38_I1.0911.00
39_Y67_V1.0751.00
39_Y77_R1.0611.00
99_K103_R1.0521.00
6_E10_N1.0501.00
78_K83_G1.0421.00
11_E14_A1.0261.00
90_D93_S1.0261.00
18_H30_E1.0111.00
10_N14_A1.0091.00
36_E80_A0.9861.00
13_A39_Y0.9831.00
22_V70_S0.9711.00
102_L105_L0.9691.00
9_L75_Y0.9471.00
58_L62_A0.9411.00
52_S69_S0.9401.00
67_V77_R0.9361.00
32_G39_Y0.9241.00
38_I78_K0.9071.00
52_S56_L0.9001.00
91_P94_K0.8961.00
46_K52_S0.8891.00
59_F62_A0.8801.00
97_K101_I0.8791.00
102_L106_L0.8581.00
38_I83_G0.8571.00
22_V75_Y0.8371.00
18_H37_Y0.8361.00
9_L41_L0.8301.00
3_E6_E0.8260.99
23_G28_T0.8190.99
55_Y59_F0.8070.99
66_Y76_F0.8070.99
41_L75_Y0.7880.99
96_E103_R0.7860.99
89_T93_S0.7850.99
19_L68_G0.7800.99
58_L61_D0.7780.99
55_Y58_L0.7760.99
5_E9_L0.7700.99
56_L60_E0.7580.99
54_E57_E0.7340.99
58_L89_T0.7260.99
42_D100_R0.7020.98
8_W27_Y0.6960.98
40_R87_I0.6930.98
32_G35_G0.6850.98
13_A35_G0.6820.98
9_L27_Y0.6810.98
45_P100_R0.6730.98
13_A34_P0.6700.98
56_L59_F0.6690.98
55_Y89_T0.6690.98
38_I85_P0.6670.98
7_K14_A0.6650.98
103_R106_L0.6630.98
49_K52_S0.6590.98
43_Y72_G0.6580.97
45_P96_E0.6530.97
94_K98_Y0.6470.97
42_D97_K0.6460.97
64_W76_F0.6400.97
54_E58_L0.6260.97
53_E57_E0.6180.96
41_L73_W0.6120.96
91_P95_I0.6110.96
65_E79_E0.5990.96
64_W74_Q0.5980.96
96_E99_K0.5900.95
64_W85_P0.5860.95
86_E94_K0.5850.95
21_K92_E0.5820.95
12_M17_W0.5770.95
79_E82_D0.5710.94
45_P52_S0.5700.94
35_G80_A0.5690.94
53_E56_L0.5660.94
31_K34_P0.5620.94
99_K102_L0.5590.94
52_S66_Y0.5590.94
70_S105_L0.5560.94
24_F71_G0.5470.93
44_L74_Q0.5440.93
98_Y102_L0.5430.93
44_L55_Y0.5390.92
33_E53_E0.5350.92
80_A83_G0.5330.92
59_F93_S0.5320.92
10_N34_P0.5320.92
32_G36_E0.5300.92
10_N64_W0.5250.91
17_W54_E0.5170.91
10_N37_Y0.5140.91
94_K97_K0.5140.91
95_I98_Y0.5130.91
48_S71_G0.5120.90
20_K26_G0.5100.90
20_K24_F0.5090.90
73_W77_R0.5080.90
95_I99_K0.5080.90
55_Y62_A0.5060.90
22_V27_Y0.5060.90
17_W98_Y0.5060.90
48_S96_E0.5040.90
27_Y42_D0.5010.90
18_H33_E0.5000.89
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4p78C 1 0.5545 23.4 0.877 Contact Map
4c26A 1 0.5909 22.1 0.878 Contact Map
3tc3A 1 0.8636 10.8 0.894 Contact Map
3lxuX 2 0.6182 10.1 0.896 Contact Map
1whzA 1 0.5909 9 0.898 Contact Map
2zfuA 1 0.5364 8.4 0.9 Contact Map
2j6vA 1 0.9545 8.1 0.9 Contact Map
4nnbA 1 0.5364 7.7 0.901 Contact Map
4khoA 1 0.4545 6.8 0.904 Contact Map
4m1bA 1 0.2636 6.7 0.904 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0054 seconds.