GREMLIN Database
DUF2973 - Protein of unknown function (DUF2973)
PFAM: PF11189 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 68 (68)
Sequences: 781 (443)
Seq/√Len: 53.8
META: 0.836

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
41_D44_G3.1571.00
48_I53_L2.4101.00
16_L19_R2.1891.00
63_E66_T1.9881.00
13_L59_I1.9821.00
4_L11_T1.8520.99
54_D58_N1.7890.99
47_T67_V1.6290.98
15_W20_V1.6130.98
7_I10_F1.6070.98
47_T53_L1.5720.98
24_G28_L1.5090.97
42_R45_R1.5050.97
35_S38_N1.5020.97
15_W19_R1.4370.96
63_E67_V1.4320.96
5_L9_A1.4160.96
40_N58_N1.3990.96
26_I64_L1.3730.95
16_L67_V1.3600.95
5_L36_S1.3210.94
10_F54_D1.3020.94
65_L68_R1.2580.93
19_R60_T1.2480.92
41_D45_R1.2270.92
44_G47_T1.2180.91
45_R48_I1.1980.91
27_A30_R1.1650.90
21_M54_D1.1460.89
30_R33_Q1.1170.87
29_S34_R1.1130.87
13_L17_A1.1080.87
3_P7_I1.1040.87
36_S40_N1.0900.86
36_S39_S1.0870.86
22_I54_D1.0870.86
11_T25_L1.0780.85
18_F31_E1.0690.85
6_Y52_L1.0410.83
62_E65_L1.0400.83
48_I66_T1.0100.82
46_Y55_K1.0010.81
46_Y58_N0.9980.81
35_S39_S0.9960.81
35_S40_N0.9880.80
20_V63_E0.9760.79
2_F15_W0.9620.78
7_I21_M0.9380.76
33_Q68_R0.9350.76
54_D63_E0.9320.76
40_N45_R0.9280.76
4_L33_Q0.9240.75
32_S61_D0.9210.75
28_L31_E0.8660.71
34_R38_N0.8620.70
8_L30_R0.8450.69
39_S42_R0.8190.66
13_L27_A0.8140.66
21_M26_I0.8100.65
53_L65_L0.8030.65
1_L46_Y0.7700.61
15_W60_T0.7650.61
24_G27_A0.7550.60
29_S32_S0.7450.59
32_S37_N0.7400.58
37_N40_N0.7320.58
6_Y15_W0.7270.57
4_L31_E0.7110.55
38_N46_Y0.6920.53
20_V23_R0.6840.52
4_L7_I0.6740.51
2_F18_F0.6710.51
60_T64_L0.6620.50
31_E34_R0.6510.49
62_E68_R0.6430.48
7_I26_I0.6340.47
4_L8_L0.6330.47
18_F22_I0.6320.47
17_A23_R0.6110.45
37_N41_D0.6070.44
24_G65_L0.6060.44
30_R34_R0.5990.43
1_L24_G0.5980.43
43_T47_T0.5860.42
24_G67_V0.5840.42
12_V41_D0.5770.41
9_A55_K0.5730.41
39_S61_D0.5700.40
45_R68_R0.5690.40
28_L32_S0.5650.40
20_V24_G0.5590.39
47_T59_I0.5550.39
1_L26_I0.5470.38
4_L32_S0.5450.38
35_S55_K0.5390.37
15_W18_F0.5340.37
6_Y10_F0.5280.36
26_I56_S0.5250.36
10_F20_V0.5250.36
24_G63_E0.5120.35
15_W59_I0.5030.34
6_Y53_L0.5000.34
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2wadA 1 0.3971 45.6 0.847 Contact Map
4ovdA 2 0.3529 37.2 0.855 Contact Map
4cbcA 3 0.4412 25.6 0.866 Contact Map
4ltoA 3 0.9265 17.8 0.875 Contact Map
3rvyA 3 0.4412 14.7 0.88 Contact Map
2j5lA 1 0 10.4 0.888 Contact Map
4c2mA 1 0.7794 9.7 0.889 Contact Map
1uf2A 7 0.9118 9.4 0.89 Contact Map
3j9pD 4 0.8824 9.1 0.891 Contact Map
3riqA 3 0.8676 6.5 0.898 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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