GREMLIN Database
DUF2975 - Protein of unknown function (DUF2975)
PFAM: PF11188 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 131 (115)
Sequences: 14416 (10823)
Seq/√Len: 1009.2
META: 0.838

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
124_K128_D4.1261.00
37_Q61_R3.1301.00
123_L127_N3.1061.00
37_Q58_R2.7631.00
33_V65_C2.6451.00
119_E122_E2.5551.00
63_G111_L2.4991.00
56_V121_V2.3241.00
44_T58_R2.1721.00
115_R118_R2.0581.00
63_G114_A2.0511.00
57_R61_R2.0461.00
67_L107_G1.9671.00
34_A62_I1.9621.00
33_V37_Q1.9501.00
44_T55_N1.9431.00
36_Y40_K1.9011.00
70_A73_Y1.8501.00
49_D52_S1.8351.00
44_T49_D1.6321.00
63_G107_G1.6211.00
60_R118_R1.6041.00
121_V125_E1.5781.00
64_Y68_A1.4821.00
56_V114_A1.3721.00
41_L55_N1.3611.00
33_V61_R1.3401.00
92_L95_L1.3201.00
115_R119_E1.2901.00
125_E129_L1.2851.00
42_L45_V1.2601.00
32_F36_Y1.2401.00
119_E124_K1.2371.00
81_A84_A1.2251.00
40_K58_R1.2211.00
118_R121_V1.2141.00
64_Y111_L1.2121.00
66_L110_L1.2001.00
94_L97_L1.1961.00
66_L107_G1.1881.00
125_E128_D1.1881.00
44_T54_E1.1851.00
36_Y39_R1.1801.00
39_R43_G1.1721.00
48_G119_E1.1721.00
49_D124_K1.1511.00
62_I110_L1.1331.00
53_P125_E1.1301.00
118_R122_E1.1291.00
81_A85_A1.1151.00
37_Q65_C1.0801.00
51_F123_L1.0721.00
37_Q40_K1.0221.00
80_L85_A1.0101.00
53_P118_R1.0021.00
70_A74_V1.0021.00
61_R65_C1.0011.00
78_I81_A0.9861.00
73_Y76_G0.9801.00
127_N130_T0.9691.00
77_G81_A0.9661.00
60_R114_A0.9651.00
79_L82_L0.9641.00
79_L84_A0.9641.00
45_V117_F0.9621.00
65_C69_I0.9211.00
57_R60_R0.9071.00
59_L117_F0.9001.00
56_V60_R0.8961.00
43_G47_R0.8901.00
29_I33_V0.8871.00
107_G111_L0.8821.00
78_I82_L0.8791.00
43_G46_R0.8721.00
44_T52_S0.8651.00
50_P116_V0.8641.00
45_V50_P0.8621.00
60_R115_R0.8601.00
72_L76_G0.8541.00
61_R64_Y0.8531.00
93_V96_G0.8481.00
82_L85_A0.8481.00
45_V55_N0.8481.00
53_P57_R0.8441.00
60_R64_Y0.8431.00
74_V78_I0.8421.00
39_R46_R0.8381.00
124_K127_N0.8331.00
86_F89_A0.8301.00
41_L45_V0.7981.00
91_G95_L0.7941.00
70_A76_G0.7931.00
59_L110_L0.7871.00
52_S55_N0.7871.00
54_E58_R0.7811.00
72_L75_A0.7731.00
31_F34_A0.7721.00
53_P121_V0.7481.00
24_A27_A0.7481.00
71_L75_A0.7441.00
72_L80_L0.7391.00
126_E129_L0.7381.00
80_L84_A0.7381.00
70_A75_A0.7241.00
35_L39_R0.7201.00
109_L113_L0.7151.00
19_P22_L0.7151.00
114_A118_R0.7151.00
30_L69_I0.7121.00
41_L58_R0.7111.00
76_G85_A0.6931.00
87_D90_P0.6851.00
56_V63_G0.6821.00
54_E57_R0.6791.00
73_Y80_L0.6741.00
94_L98_G0.6721.00
80_L83_L0.6671.00
127_N131_V0.6651.00
50_P119_E0.6561.00
120_G123_L0.6521.00
76_G80_L0.6451.00
77_G83_L0.6361.00
89_A92_L0.6351.00
26_L29_I0.6321.00
103_S107_G0.6281.00
17_R21_L0.6271.00
78_I84_A0.6251.00
73_Y77_G0.6211.00
27_A30_L0.6211.00
116_V120_G0.6181.00
99_I102_A0.6181.00
77_G85_A0.6141.00
34_A65_C0.6121.00
32_F35_L0.6041.00
51_F120_G0.6041.00
122_E125_E0.6031.00
74_V77_G0.6011.00
75_A78_I0.5971.00
28_A32_F0.5901.00
71_L74_V0.5801.00
76_G79_L0.5791.00
72_L84_A0.5781.00
72_L81_A0.5681.00
77_G84_A0.5671.00
21_L25_L0.5611.00
75_A79_L0.5541.00
40_K54_E0.5541.00
78_I83_L0.5531.00
44_T50_P0.5451.00
73_Y79_L0.5401.00
66_L106_I0.5391.00
62_I66_L0.5381.00
70_A77_G0.5381.00
85_A89_A0.5361.00
85_A88_D0.5311.00
84_A90_P0.5281.00
41_L62_I0.5261.00
52_S56_V0.5241.00
32_F39_R0.5201.00
104_L107_G0.5201.00
120_G124_K0.5141.00
77_G80_L0.5131.00
117_F120_G0.5131.00
69_I103_S0.5101.00
34_A37_Q0.5101.00
56_V118_R0.5081.00
115_R122_E0.5071.00
95_L98_G0.5051.00
45_V59_L0.5051.00
91_G94_L0.5021.00
30_L65_C0.5021.00
55_N58_R0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4hyjA 2 0.8855 23.8 0.875 Contact Map
4qi1A 3 0.8473 14.8 0.886 Contact Map
3m73A 3 0.3969 7.3 0.901 Contact Map
4xtlA 1 0.8702 4.2 0.912 Contact Map
4hw9A 3 0.855 3.6 0.915 Contact Map
5ajiA 3 0.9008 3.2 0.917 Contact Map
3am6A 3 0.8397 3.2 0.917 Contact Map
4fbzA 3 0.9008 3.1 0.917 Contact Map
4p6vB 1 0.4504 2.6 0.921 Contact Map
3udcA 3 0.9008 2.6 0.921 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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