GREMLIN Database
DUF2971 - Protein of unknown function (DUF2971)
PFAM: PF11185 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 82 (79)
Sequences: 17432 (16031)
Seq/√Len: 1803.7
META: 0.901

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
4_H76_Y4.4341.00
7_D10_K4.1781.00
3_S74_W3.3791.00
3_S8_N2.6741.00
72_K75_S2.4221.00
42_D72_K2.3161.00
4_H77_E2.2481.00
18_T80_W1.9851.00
3_S9_H1.9371.00
4_H74_W1.7131.00
3_S76_Y1.6901.00
12_V15_G1.6451.00
1_M13_C1.5791.00
18_T21_L1.5491.00
1_M4_H1.5161.00
74_W77_E1.4771.00
31_E34_K1.4671.00
1_M76_Y1.4641.00
12_V16_F1.3861.00
6_A11_G1.3741.00
71_S74_W1.3441.00
20_K23_E1.3141.00
30_A34_K1.2801.00
25_L28_L1.2761.00
66_I69_T1.2391.00
21_L24_L1.2241.00
27_E30_A1.1121.00
62_E66_I1.0861.00
15_G18_T1.0851.00
17_D20_K1.0451.00
16_F74_W1.0221.00
9_H74_W0.9801.00
4_H8_N0.9721.00
29_L32_L0.9691.00
29_L33_L0.9631.00
41_S44_R0.9621.00
25_L30_A0.9551.00
62_E65_E0.9451.00
42_D45_P0.9421.00
28_L32_L0.9411.00
4_H73_D0.9161.00
13_C16_F0.9151.00
2_W5_Y0.9091.00
24_L28_L0.8891.00
1_M15_G0.8891.00
13_C74_W0.8801.00
53_L58_E0.8791.00
70_K74_W0.8741.00
63_L67_L0.8721.00
1_M16_F0.8601.00
5_Y74_W0.8541.00
18_T22_F0.8361.00
21_L25_L0.8361.00
65_E69_T0.8311.00
41_S45_P0.8301.00
57_L60_L0.8141.00
6_A13_C0.8051.00
57_L61_E0.8041.00
28_L31_E0.7951.00
30_A33_L0.7891.00
28_L33_L0.7881.00
6_A10_K0.7811.00
75_S78_K0.7801.00
64_D67_L0.7771.00
16_F80_W0.7761.00
54_D57_L0.7761.00
44_R71_S0.7691.00
54_D58_E0.7641.00
65_E68_L0.7611.00
4_H13_C0.7561.00
16_F71_S0.7481.00
3_S71_S0.7411.00
17_D21_L0.7401.00
22_F25_L0.7101.00
77_E81_R0.7001.00
1_M5_Y0.6941.00
53_L57_L0.6901.00
43_E47_I0.6891.00
61_E64_D0.6781.00
44_R48_D0.6671.00
41_S72_K0.6581.00
24_L29_L0.6391.00
25_L29_L0.6361.00
3_S6_A0.6361.00
6_A38_V0.6351.00
26_K29_L0.6321.00
19_D22_F0.6281.00
23_E28_L0.6271.00
50_L54_D0.6211.00
56_L59_L0.6191.00
23_E26_K0.6191.00
24_L27_E0.6161.00
49_I52_L0.6121.00
63_L66_I0.6081.00
9_H71_S0.6041.00
1_M80_W0.6041.00
16_F70_K0.5931.00
29_L34_K0.5911.00
61_E67_L0.5891.00
4_H71_S0.5821.00
56_L60_L0.5751.00
21_L26_K0.5691.00
45_P48_D0.5631.00
22_F27_E0.5601.00
58_E61_E0.5581.00
3_S73_D0.5571.00
64_D68_L0.5551.00
61_E65_E0.5461.00
27_E32_L0.5451.00
13_C77_E0.5311.00
27_E31_E0.5301.00
59_L64_D0.5301.00
12_V74_W0.5261.00
6_A9_H0.5211.00
27_E34_K0.5171.00
59_L62_E0.5111.00
71_S76_Y0.5081.00
57_L62_E0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3dmeA 2 0.3293 2.2 0.88 Contact Map
4fusA 1 0.8537 2.1 0.883 Contact Map
2co3A 2 0.8415 2 0.883 Contact Map
1l1yA 1 0.878 1.8 0.887 Contact Map
3n12A 1 0.3537 1.8 0.887 Contact Map
1jndA 1 0.3415 1.5 0.891 Contact Map
1sdiA 1 0.4146 1.5 0.892 Contact Map
4jz5A 1 0.378 1.4 0.892 Contact Map
3ianA 1 0.4878 1.4 0.894 Contact Map
3lvqE 1 0.939 1.4 0.894 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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