GREMLIN Database
AlgF - Alginate O-acetyl transferase AlgF
PFAM: PF11182 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 179 (172)
Sequences: 512 (401)
Seq/√Len: 30.6
META: 0.648

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
135_F144_G6.0591.00
133_A136_E3.4171.00
102_D116_Y3.2951.00
146_R149_N3.2351.00
26_G84_G2.6281.00
85_E101_E2.5841.00
126_K158_F2.5360.99
170_V174_R2.4880.99
28_A81_L2.4750.99
33_V88_T2.3660.99
110_K118_L2.3450.99
127_T130_G2.2800.99
163_K166_D2.2560.99
169_P174_R2.1600.98
134_V155_L2.1040.98
77_L113_L2.0350.98
21_P155_L2.0160.97
127_T147_A1.9570.97
137_D140_P1.9520.97
151_V155_L1.9240.96
148_I151_V1.9150.96
166_D169_P1.8180.95
117_N146_R1.8070.95
24_P134_V1.7150.93
28_A33_V1.7030.93
99_L123_A1.6490.92
105_F112_L1.6460.92
49_L58_S1.6280.91
49_L52_L1.6180.91
33_V57_A1.5860.90
73_G89_V1.5860.90
172_L176_E1.5750.90
122_P125_L1.5560.89
23_P62_V1.5520.89
35_A112_L1.5500.89
75_K91_V1.5290.89
27_S64_P1.5270.88
20_A86_F1.5110.88
6_L9_L1.4900.87
24_P130_G1.4630.86
25_A32_V1.4250.85
102_D111_A1.4100.84
101_E104_P1.4030.84
96_A122_P1.3880.83
26_G148_I1.3520.81
92_D113_L1.3220.80
90_V141_G1.3100.79
28_A64_P1.3090.79
21_P24_P1.3060.79
153_V156_A1.3040.79
113_L164_V1.2970.79
34_N146_R1.2910.78
69_T78_P1.2780.78
11_A151_V1.2690.77
72_V111_A1.2570.76
98_V113_L1.2560.76
22_G25_A1.2510.76
115_F125_L1.2470.76
57_A109_L1.2260.75
23_P149_N1.2130.74
148_I175_G1.1910.72
17_G157_V1.1890.72
32_V61_R1.1880.72
53_A90_V1.1690.71
45_G53_A1.1650.71
65_A134_V1.1550.70
100_V117_N1.1530.70
71_S115_F1.1500.70
32_V44_V1.1270.68
24_P149_N1.1050.67
60_Y116_Y1.0850.65
138_V146_R1.0840.65
22_G85_E1.0840.65
115_F135_F1.0800.65
16_A24_P1.0790.65
30_V113_L1.0640.64
54_A67_K1.0640.64
20_A145_R1.0540.63
21_P28_A1.0390.62
53_A74_G1.0280.61
21_P115_F0.9990.59
113_L155_L0.9990.59
22_G145_R0.9850.57
150_P176_E0.9840.57
69_T75_K0.9810.57
60_Y102_D0.9700.56
60_Y100_V0.9650.56
87_Y125_L0.9630.56
101_E106_D0.9560.55
20_A23_P0.9500.55
109_L154_S0.9440.54
132_T163_K0.9410.54
34_N152_K0.9410.54
139_A144_G0.9370.54
20_A24_P0.9360.54
108_A112_L0.9340.53
20_A109_L0.9340.53
24_P153_V0.9300.53
172_L175_G0.9290.53
103_P140_P0.9280.53
20_A170_V0.9170.52
17_G129_D0.9040.51
20_A27_S0.9030.51
55_G142_A0.8990.51
79_V148_I0.8990.51
59_D116_Y0.8960.50
21_P62_V0.8910.50
167_L173_E0.8890.50
162_K165_A0.8880.50
43_T54_A0.8610.48
115_F168_K0.8590.47
173_E176_E0.8580.47
130_G158_F0.8560.47
67_K99_L0.8500.47
15_D61_R0.8490.47
89_V99_L0.8490.47
138_V160_G0.8490.47
134_V149_N0.8440.46
138_V157_V0.8400.46
90_V100_V0.8330.45
132_T153_V0.8300.45
21_P102_D0.8230.45
30_V139_A0.8230.45
35_A120_D0.8220.44
23_P81_L0.8220.44
167_L171_A0.8200.44
19_Y24_P0.8060.43
20_A107_N0.8060.43
42_V72_V0.8050.43
115_F157_V0.8030.43
67_K94_G0.8020.43
28_A63_V0.8010.43
85_E106_D0.7920.42
10_A36_S0.7870.42
116_Y143_S0.7860.42
46_S51_D0.7830.41
10_A120_D0.7780.41
159_C174_R0.7700.40
46_S142_A0.7660.40
86_F151_V0.7620.40
28_A123_A0.7480.39
79_V136_E0.7480.39
70_L74_G0.7430.38
46_S49_L0.7420.38
113_L152_K0.7410.38
109_L119_S0.7370.38
105_F110_K0.7360.38
50_Q91_V0.7340.38
48_A133_A0.7280.37
83_A113_L0.7270.37
48_A100_V0.7240.37
108_A150_P0.7230.37
136_E141_G0.7220.37
56_G87_Y0.7180.36
114_A176_E0.7130.36
126_K130_G0.7130.36
67_K152_K0.7060.36
72_V155_L0.7060.36
169_P175_G0.7020.35
166_D170_V0.6990.35
35_A91_V0.6980.35
166_D174_R0.6930.35
70_L130_G0.6920.35
35_A45_G0.6890.34
66_G118_L0.6840.34
129_D158_F0.6820.34
156_A160_G0.6820.34
170_V175_G0.6760.33
105_F108_A0.6740.33
20_A105_F0.6660.33
88_T165_A0.6640.33
85_E89_V0.6590.32
116_Y141_G0.6570.32
168_K171_A0.6560.32
97_L121_K0.6540.32
28_A58_S0.6530.32
11_A42_V0.6480.31
20_A114_A0.6470.31
71_S76_S0.6410.31
10_A162_K0.6380.31
170_V176_E0.6370.31
23_P29_F0.6350.31
15_D131_K0.6320.30
68_Y81_L0.6320.30
8_S160_G0.6320.30
127_T134_V0.6310.30
76_S120_D0.6290.30
135_F150_P0.6200.30
23_P169_P0.6180.29
39_P58_S0.6170.29
22_G114_A0.6160.29
79_V90_V0.6140.29
115_F138_V0.6130.29
96_A161_D0.6120.29
47_K53_A0.6110.29
38_A93_A0.6100.29
115_F131_K0.6100.29
36_S88_T0.6080.29
117_N125_L0.6070.29
19_Y31_R0.6070.29
107_N114_A0.6060.29
34_N54_A0.6040.28
96_A121_K0.6040.28
150_P174_R0.6040.28
52_L58_S0.6030.28
149_N156_A0.6010.28
49_L100_V0.5980.28
120_D136_E0.5980.28
17_G20_A0.5970.28
169_P176_E0.5920.28
126_K129_D0.5910.28
70_L99_L0.5910.28
80_T139_A0.5860.27
24_P62_V0.5850.27
158_F163_K0.5820.27
155_L168_K0.5810.27
76_S92_D0.5810.27
42_V83_A0.5790.27
94_G138_V0.5790.27
124_S137_D0.5760.27
45_G48_A0.5750.27
64_P157_V0.5750.27
63_V68_Y0.5750.27
7_A76_S0.5740.27
13_A141_G0.5730.26
91_V165_A0.5730.26
93_A124_S0.5710.26
37_D69_T0.5660.26
123_A159_C0.5630.26
131_K145_R0.5630.26
75_K96_A0.5600.26
159_C162_K0.5560.25
13_A104_P0.5520.25
28_A88_T0.5490.25
16_A28_A0.5470.25
110_K155_L0.5460.25
8_S132_T0.5420.25
133_A148_I0.5410.25
25_A61_R0.5380.24
62_V68_Y0.5340.24
58_S63_V0.5340.24
135_F157_V0.5320.24
112_L145_R0.5310.24
125_L143_S0.5300.24
21_P29_F0.5300.24
127_T158_F0.5260.24
27_S161_D0.5240.24
28_A31_R0.5190.23
71_S122_P0.5180.23
102_D105_F0.5120.23
39_P52_L0.5090.23
32_V143_S0.5090.23
18_L27_S0.5090.23
20_A84_G0.5080.23
22_G84_G0.5070.23
127_T131_K0.5050.22
30_V92_D0.5010.22
114_A173_E0.5000.22
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ifrA 1 0.6201 20.3 0.94 Contact Map
4uqdA 1 0.4581 11.6 0.946 Contact Map
1id2A 1 0.5028 10.5 0.947 Contact Map
2rdyA 2 0.5084 9.3 0.948 Contact Map
4i3gA 1 0.4749 9.2 0.948 Contact Map
3c75A 1 0.4972 6.5 0.952 Contact Map
2k6wA 1 0.6425 6.3 0.952 Contact Map
2y24A 1 0.4693 5.9 0.953 Contact Map
1h54A 2 0.4022 5.4 0.954 Contact Map
2x41A 1 0.5084 4.6 0.955 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0069 seconds.