GREMLIN Database
DUF2963 - Protein of unknown function (DUF2963)
PFAM: PF11178 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 51 (48)
Sequences: 1150 (1040)
Seq/√Len: 150.2
META: 0.73

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
17_N43_N4.0221.00
16_S42_S3.1131.00
6_K32_K2.4221.00
13_E23_K2.2881.00
22_I47_T2.1991.00
39_E48_K2.0551.00
15_D20_N2.0461.00
3_A29_A1.9091.00
41_D45_N1.7671.00
7_L11_I1.6681.00
7_L10_Y1.4771.00
23_K48_K1.3881.00
34_I38_E1.3781.00
21_L24_E1.2401.00
11_I37_I1.2131.00
14_Y40_Y1.1471.00
24_E49_E1.1150.99
13_E39_E1.0960.99
33_T38_E1.0220.99
15_D41_D1.0120.99
25_T33_T1.0060.99
42_S45_N1.0020.99
8_I11_I1.0020.99
28_N31_G0.9660.98
10_Y27_Y0.9510.98
7_L33_T0.9340.98
9_S35_Y0.8640.97
19_G44_G0.8500.96
12_Y38_E0.8320.96
46_L49_E0.8220.96
1_Y27_Y0.8200.96
4_D7_L0.8080.95
6_K9_S0.8050.95
8_I37_I0.8030.95
14_Y21_L0.8000.95
14_Y19_G0.7990.95
8_I34_I0.7920.95
3_A26_Y0.7890.95
23_K39_E0.7270.92
17_N21_L0.7170.91
34_I37_I0.7060.91
12_Y21_L0.6910.90
2_N10_Y0.6840.89
7_L25_T0.6800.89
7_L34_I0.6780.89
21_L46_L0.6720.89
16_S22_I0.6660.88
40_Y46_L0.6630.88
35_Y38_E0.6520.87
35_Y48_K0.6510.87
24_E36_Y0.6500.87
9_S12_Y0.6360.86
11_I33_T0.6290.85
12_Y27_Y0.6260.85
4_D30_D0.6060.83
26_Y36_Y0.6040.83
25_T34_I0.6040.83
26_Y32_K0.6000.82
28_N32_K0.6000.82
5_G20_N0.5990.82
6_K11_I0.5820.80
20_N45_N0.5810.80
16_S26_Y0.5610.78
21_L26_Y0.5580.78
2_N35_Y0.5360.75
14_Y17_N0.5340.74
14_Y20_N0.5260.73
5_G31_G0.5160.72
36_Y41_D0.5150.72
2_N11_I0.5140.72
8_I24_E0.5100.71
21_L38_E0.5000.70
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4iglB 1 0.9804 77.7 0.69 Contact Map
4o9xA 1 0.9804 77.3 0.691 Contact Map
4iglA 1 0.9804 66 0.717 Contact Map
4r03A 1 0.9804 58.2 0.73 Contact Map
4r8oA 2 0.8235 43.6 0.752 Contact Map
3mswA 1 0.9608 42.1 0.754 Contact Map
4x7rA 1 0.902 32.9 0.769 Contact Map
4ld1A 1 0.5098 30.5 0.772 Contact Map
3hiaA 3 0.7647 21.7 0.788 Contact Map
4by2A 1 0.2745 17.4 0.797 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0042 seconds.