GREMLIN Database
DUF2970 - Protein of unknown function (DUF2970)
PFAM: PF11174 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 56 (56)
Sequences: 6000 (3354)
Seq/√Len: 448.2
META: 0.903

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
29_N32_H2.3921.00
18_R21_R2.3561.00
20_N23_R2.1871.00
18_R22_E2.1151.00
50_L54_L1.9071.00
12_F40_G1.8961.00
8_V36_A1.8141.00
46_L50_L1.6971.00
21_R25_F1.6441.00
5_V40_G1.5901.00
5_V36_A1.5471.00
52_V55_V1.5171.00
12_F41_A1.4971.00
17_K20_N1.4721.00
7_A28_L1.4491.00
47_T51_L1.4441.00
49_V53_R1.3891.00
30_P34_I1.3561.00
28_L33_V1.3131.00
51_L55_V1.3071.00
37_G41_A1.2991.00
50_L53_R1.2501.00
23_R27_Q1.2081.00
3_Q23_R1.1851.00
16_R20_N1.1631.00
2_L6_K1.1591.00
4_V36_A1.1551.00
45_V49_V1.1451.00
31_V35_I1.1281.00
3_Q6_K1.0321.00
28_L32_H1.0051.00
22_E26_A0.9951.00
9_L40_G0.9631.00
36_A40_G0.9331.00
51_L54_L0.9261.00
3_Q27_Q0.9221.00
7_A24_D0.9151.00
6_K20_N0.8851.00
35_I39_I0.8741.00
1_F5_V0.8731.00
4_V32_H0.8711.00
3_Q20_N0.8531.00
10_W20_N0.8461.00
39_I43_L0.8441.00
48_L55_V0.8431.00
19_A22_E0.8301.00
42_A46_L0.8191.00
48_L51_L0.7831.00
44_F48_L0.7551.00
19_A23_R0.7531.00
39_I46_L0.7521.00
46_L49_V0.7521.00
10_W13_F0.7371.00
7_A16_R0.7281.00
22_E25_F0.7221.00
4_V33_V0.7181.00
8_V40_G0.7021.00
7_A21_R0.6961.00
6_K10_W0.6851.00
7_A33_V0.6701.00
4_V28_L0.6481.00
8_V12_F0.6440.99
9_L13_F0.6330.99
2_L5_V0.6160.99
23_R26_A0.6090.99
34_I38_L0.6080.99
34_I45_V0.5980.99
43_L47_T0.5900.99
6_K9_L0.5820.99
16_R28_L0.5810.99
12_F37_G0.5800.99
36_A39_I0.5790.99
16_R24_D0.5750.99
42_A45_V0.5720.99
32_H35_I0.5650.99
40_G43_L0.5570.99
38_L42_A0.5560.99
10_W17_K0.5510.98
10_W16_R0.5350.98
32_H36_A0.5270.98
13_F44_F0.5170.98
16_R33_V0.5130.97
25_F28_L0.5020.97
10_W37_G0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3l1lA 2 0.9643 18.3 0.814 Contact Map
3giaA 1 0.9643 13.8 0.824 Contact Map
4djkA 2 0.9643 13.6 0.825 Contact Map
3j9pD 4 1 5.4 0.854 Contact Map
3e4oA 2 0 5.1 0.855 Contact Map
1iijA 1 0.5714 4.9 0.857 Contact Map
2l9uA 2 0.5179 4.1 0.862 Contact Map
2l2tA 2 0.6071 4.1 0.862 Contact Map
2ks1B 1 0.625 3.3 0.868 Contact Map
2kncB 1 0.625 3.1 0.87 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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