GREMLIN Database
DUF2958 - Protein of unknown function (DUF2958)
PFAM: PF11171 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 111 (101)
Sequences: 4026 (2658)
Seq/√Len: 264.5
META: 0.917

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
33_T36_G2.9631.00
42_L69_V2.9601.00
35_D79_G2.8491.00
51_D72_S2.5351.00
35_D84_P2.2401.00
33_T79_G2.0891.00
22_E25_P2.0511.00
33_T38_A2.0431.00
33_T85_I1.9931.00
95_K99_E1.9401.00
58_D62_G1.8981.00
58_D64_P1.8831.00
42_L53_A1.8771.00
30_K39_T1.8751.00
57_C69_V1.8601.00
35_D81_L1.8071.00
17_S25_P1.7621.00
45_L53_A1.7451.00
3_T6_I1.7231.00
93_P100_Y1.7181.00
4_K7_R1.6651.00
56_L64_P1.5961.00
38_A59_L1.5661.00
52_I68_Y1.5401.00
53_A71_L1.4721.00
66_L97_L1.4361.00
4_K8_K1.3971.00
31_L85_I1.3671.00
43_T66_L1.3071.00
78_R84_P1.3061.00
7_R45_L1.2961.00
27_P43_T1.2741.00
96_P99_E1.2731.00
7_R11_L1.2571.00
11_L14_G1.2221.00
14_G17_S1.1741.00
31_L42_L1.1691.00
51_D70_S1.1661.00
16_Q19_E1.1621.00
53_A69_V1.1521.00
47_P50_G1.1351.00
33_T37_A1.1321.00
54_F68_Y1.1301.00
59_L62_G1.1281.00
11_L15_S1.1211.00
46_D50_G1.1161.00
26_V93_P1.0671.00
31_L53_A1.0541.00
2_L7_R1.0381.00
20_G25_P1.0231.00
50_G72_S1.0211.00
35_D83_L1.0131.00
72_S76_S1.0021.00
44_E54_F0.9701.00
9_K28_V0.9681.00
2_L71_L0.9631.00
5_E9_K0.9541.00
6_I9_K0.9481.00
33_T80_P0.9391.00
26_V96_P0.9391.00
8_K12_A0.9391.00
45_L50_G0.9361.00
52_I70_S0.9271.00
79_G84_P0.9231.00
2_L31_L0.9141.00
19_E22_E0.9101.00
49_D52_I0.9041.00
17_S20_G0.9031.00
20_G23_K0.8981.00
70_S73_E0.8981.00
71_L75_E0.8811.00
25_P43_T0.8561.00
38_A61_F0.8511.00
54_F66_L0.8481.00
46_D68_Y0.8320.99
47_P52_I0.8220.99
46_D52_I0.8200.99
11_L45_L0.8120.99
6_I29_V0.8100.99
12_A15_S0.8060.99
21_P25_P0.7920.99
10_L13_N0.7900.99
27_P41_L0.7870.99
45_L52_I0.7790.99
28_V93_P0.7680.99
16_Q25_P0.7660.99
55_G58_D0.7590.99
33_T84_P0.7570.99
81_L84_P0.7550.99
37_A59_L0.7440.99
95_K100_Y0.7310.99
17_S22_E0.7310.99
34_P83_L0.7230.98
56_L66_L0.7120.98
79_G83_L0.7090.98
55_G69_V0.7090.98
34_P79_G0.6910.98
33_T77_V0.6900.98
18_A21_P0.6890.98
73_E76_S0.6850.98
25_P98_S0.6780.98
35_D80_P0.6760.98
40_W69_V0.6730.98
4_K9_K0.6730.98
30_K88_D0.6710.97
58_D61_F0.6670.97
31_L74_L0.6660.97
57_C64_P0.6580.97
6_I10_L0.6530.97
91_F94_T0.6480.97
77_V80_P0.6480.97
43_T97_L0.6440.97
32_F86_E0.6350.96
37_A62_G0.6330.96
9_K13_N0.6310.96
72_S75_E0.6240.96
74_L85_I0.6170.96
29_V42_L0.6090.96
26_V94_T0.6070.95
33_T81_L0.6040.95
41_L64_P0.5960.95
12_A16_Q0.5940.95
41_L58_D0.5890.95
13_N16_Q0.5850.94
53_A57_C0.5800.94
19_E25_P0.5760.94
35_D78_R0.5760.94
33_T83_L0.5740.94
35_D77_V0.5710.94
58_D63_E0.5690.94
6_I87_R0.5690.94
27_P64_P0.5670.94
32_F39_T0.5650.93
69_V74_L0.5610.93
17_S23_K0.5590.93
42_L45_L0.5570.93
17_S44_E0.5500.92
27_P56_L0.5490.92
24_D98_S0.5470.92
98_S101_A0.5460.92
65_E73_E0.5410.92
10_L14_G0.5380.92
25_P96_P0.5280.91
83_L86_E0.5260.91
8_K11_L0.5150.90
10_L42_L0.5130.90
2_L6_I0.5100.89
92_K95_K0.5040.89
43_T56_L0.5040.89
16_Q23_K0.5020.89
25_P66_L0.5010.89
93_P96_P0.5000.88
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2pd0A 2 0.8919 11.1 0.922 Contact Map
1sraA 1 0.9099 8.2 0.927 Contact Map
4r8aA 1 0.964 8 0.927 Contact Map
2pgsA 4 0.7928 5.9 0.932 Contact Map
2wyaA 2 0.4414 5.3 0.933 Contact Map
2f82A 2 0.4865 5 0.934 Contact Map
2p8uA 2 0.4865 4.3 0.936 Contact Map
3mlnA 2 0.7658 4.2 0.936 Contact Map
3sqzA 2 0.4324 4.1 0.936 Contact Map
1y6zA 2 0.9369 3.8 0.937 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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