GREMLIN Database
DUF2956 - Protein of unknown function (DUF2956)
PFAM: PF11169 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 102 (99)
Sequences: 665 (510)
Seq/√Len: 51.3
META: 0.68

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
33_Q37_A5.0321.00
93_S97_F4.6701.00
50_L54_R2.8081.00
50_L53_K2.5511.00
47_A50_L2.5321.00
54_R58_Q2.4651.00
38_Q42_Q2.3901.00
78_I81_R2.1711.00
13_K16_Q1.9771.00
45_A49_E1.7750.99
95_L101_L1.7720.99
88_L91_V1.6280.98
54_R57_A1.5970.98
90_L94_W1.5700.98
38_Q56_K1.5330.97
65_Q70_D1.5160.97
38_Q45_A1.5070.97
37_A53_K1.4830.97
3_E57_A1.4790.97
43_Q47_A1.4730.96
36_I40_K1.4590.96
36_I39_Y1.4580.96
50_L57_A1.4170.96
14_A44_K1.3970.95
30_Q43_Q1.3650.95
37_A50_L1.3420.94
98_A101_L1.3310.94
9_M15_T1.3130.93
2_P5_Q1.3010.93
17_K30_Q1.2770.92
53_K57_A1.2760.92
12_A25_T1.2590.92
24_Q27_L1.2530.92
63_Q72_E1.1940.90
3_E44_K1.1840.89
43_Q50_L1.1780.89
1_S4_T1.1660.88
78_I83_H1.1510.88
11_I14_A1.1480.88
15_T41_K1.1460.87
65_Q68_E1.1430.87
62_Q76_E1.1280.87
79_V83_H1.1120.86
27_L36_I1.1040.85
61_K66_S1.0960.85
51_D54_R1.0960.85
68_E72_E1.0530.83
42_Q55_K1.0120.80
7_E56_K1.0090.80
5_Q42_Q1.0090.80
49_E53_K0.9980.79
21_T24_Q0.9900.79
19_G45_A0.9830.78
78_I82_Q0.9610.76
89_L94_W0.9570.76
3_E46_K0.9530.76
84_W88_L0.9510.76
45_A99_A0.9280.74
51_D97_F0.9180.73
19_G99_A0.9110.72
47_A56_K0.9110.72
11_I38_Q0.9020.72
79_V82_Q0.8850.70
33_Q50_L0.8560.68
3_E45_A0.8480.67
26_K41_K0.8470.67
14_A39_Y0.8460.67
52_K55_K0.8450.67
68_E73_E0.8010.63
4_T44_K0.8000.62
90_L93_S0.8000.62
13_K19_G0.7890.61
84_W97_F0.7800.60
66_S74_V0.7780.60
67_Q74_V0.7690.59
83_H88_L0.7690.59
3_E38_Q0.7580.58
15_T34_K0.7580.58
33_Q56_K0.7570.58
62_Q92_L0.7530.58
25_T31_G0.7490.57
66_S69_E0.7410.57
5_Q50_L0.7380.56
67_Q88_L0.7350.56
64_Q75_E0.7310.56
83_H86_P0.7260.55
80_Y83_H0.7200.54
66_S75_E0.7110.53
77_K83_H0.7070.53
64_Q72_E0.7050.53
44_K51_D0.7030.53
69_E74_V0.6980.52
10_K101_L0.6940.52
65_Q72_E0.6900.51
42_Q58_Q0.6900.51
26_K71_E0.6890.51
16_Q23_E0.6880.51
8_A12_A0.6860.51
73_E76_E0.6820.50
14_A43_Q0.6660.49
96_G100_Y0.6590.48
6_D14_A0.6520.47
21_T85_L0.6510.47
7_E45_A0.6510.47
58_Q96_G0.6490.47
2_P49_E0.6480.47
23_E28_I0.6470.47
37_A55_K0.6420.46
68_E71_E0.6400.46
22_K36_I0.6390.46
94_W97_F0.6380.46
6_D78_I0.6380.46
37_A52_K0.6370.46
13_K95_L0.6280.45
66_S101_L0.6240.44
63_Q69_E0.6080.43
6_D63_Q0.6040.42
17_K53_K0.5970.42
68_E78_I0.5890.41
17_K41_K0.5880.41
17_K55_K0.5870.41
27_L40_K0.5850.41
2_P38_Q0.5840.40
13_K23_E0.5780.40
91_V95_L0.5720.39
26_K56_K0.5700.39
89_L93_S0.5600.38
10_K57_A0.5590.38
31_G46_K0.5580.38
33_Q58_Q0.5580.38
41_K93_S0.5550.38
66_S70_D0.5530.37
96_G99_A0.5410.36
43_Q101_L0.5400.36
97_F101_L0.5350.36
67_Q99_A0.5330.35
68_E88_L0.5330.35
71_E82_Q0.5280.35
15_T37_A0.5230.34
14_A52_K0.5190.34
4_T38_Q0.5150.34
64_Q67_Q0.5150.34
66_S78_I0.5060.33
27_L39_Y0.5040.33
37_A44_K0.5030.33
9_M18_P0.5030.33
72_E75_E0.5010.32
5_Q40_K0.5000.32
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4zw9A 1 0.2549 20.1 0.931 Contact Map
4j05A 3 0.1765 12.7 0.937 Contact Map
1pw4A 1 0.3824 10.4 0.939 Contact Map
4l6vi 1 0.2647 10.3 0.939 Contact Map
1jb0I 1 0.2647 8.9 0.941 Contact Map
4twkA 2 0.2843 7.2 0.943 Contact Map
2wscI 1 0.2059 6.8 0.944 Contact Map
2onkC 2 0.2059 6.3 0.945 Contact Map
4binA 1 0.402 6.3 0.945 Contact Map
3wu2L 1 0.3333 6 0.945 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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