GREMLIN Database
DUF2955 - Protein of unknown function (DUF2955)
PFAM: PF11168 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 140 (138)
Sequences: 1802 (1251)
Seq/√Len: 106.5
META: 0.794

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
8_G35_L3.5241.00
111_V118_L3.3231.00
14_A18_G3.1231.00
122_L126_L3.0691.00
15_V19_L2.5811.00
30_L33_L2.4801.00
64_S112_G2.3071.00
43_L46_G2.2981.00
42_P45_A2.2591.00
81_L105_L2.1601.00
78_V106_T2.1531.00
13_L17_Y2.1101.00
21_W24_P2.0821.00
88_L93_G2.0211.00
53_L130_A1.9521.00
73_V76_L1.8751.00
109_P113_S1.8041.00
67_L77_L1.7601.00
89_G98_G1.7451.00
9_T32_V1.7141.00
17_Y24_P1.6881.00
40_P46_G1.6781.00
54_A127_V1.6721.00
12_A31_A1.6131.00
109_P119_A1.6051.00
71_P75_L1.5681.00
60_G112_G1.5511.00
134_V137_V1.4941.00
46_G138_W1.4821.00
49_L53_L1.4751.00
44_K48_G1.4741.00
35_L86_F1.4471.00
40_P45_A1.4451.00
41_P45_A1.4151.00
57_A129_G1.3981.00
23_L122_L1.3971.00
73_V77_L1.3861.00
133_A137_V1.3641.00
95_P99_T1.3601.00
59_A85_S1.3420.99
125_A129_G1.3210.99
117_A120_L1.3040.99
86_F92_G1.2420.99
6_A10_T1.2400.99
119_A123_A1.2300.99
66_L73_V1.2290.99
49_L52_V1.2040.99
98_G110_V1.1980.99
57_A123_A1.1840.99
63_L96_L1.1770.99
135_L139_L1.1500.98
9_T22_P1.1500.98
29_V49_L1.1470.98
87_Y92_G1.1470.98
127_V134_V1.1370.98
59_A108_I1.1070.98
129_G132_L1.1050.98
30_L34_L1.0990.98
32_V64_S1.0910.98
36_S39_P1.0830.98
43_L47_L1.0700.97
90_A93_G1.0590.97
7_L54_A1.0420.97
113_S116_P1.0400.97
89_G95_P1.0390.97
50_V127_V1.0280.97
27_A31_A1.0260.97
3_L8_G1.0260.97
38_P41_P1.0120.96
31_A136_V1.0120.96
55_L58_G1.0110.96
47_L139_L1.0000.96
100_L104_G0.9850.96
8_G21_W0.9850.96
72_L76_L0.9840.96
128_V132_L0.9840.96
15_V18_G0.9710.96
10_T14_A0.9680.95
35_L92_G0.9630.95
22_P25_F0.9560.95
33_L66_L0.9490.95
52_V97_L0.9430.95
128_V139_L0.9420.95
5_L8_G0.9410.95
2_I12_A0.9280.94
56_A87_Y0.9270.94
65_P74_G0.9250.94
27_A39_P0.9240.94
60_G108_I0.9170.94
52_V56_A0.9140.94
115_S118_L0.9130.94
12_A68_L0.8910.93
130_A133_A0.8840.93
76_L80_L0.8680.92
18_G129_G0.8560.91
15_V21_W0.8560.91
62_L124_L0.8530.91
64_S120_L0.8440.91
85_S101_L0.8420.91
3_L35_L0.8410.91
34_L60_G0.8390.91
45_A48_G0.8370.91
70_Y76_L0.8340.90
111_V122_L0.8320.90
18_G117_A0.8320.90
42_P138_W0.8300.90
47_L76_L0.8140.89
43_L50_V0.8130.89
40_P75_L0.8130.89
121_A125_A0.8110.89
84_L88_L0.8090.89
108_I123_A0.8040.89
128_V131_L0.7960.88
98_G114_V0.7810.87
10_T131_L0.7740.87
133_A136_V0.7730.87
26_L44_K0.7730.87
18_G60_G0.7680.86
23_L26_L0.7610.86
88_L107_L0.7600.86
69_H102_L0.7510.85
48_G51_L0.7480.85
57_A127_V0.7410.84
46_G134_V0.7300.83
63_L78_V0.7230.83
122_L127_V0.7190.82
56_A89_G0.7190.82
53_L100_L0.7170.82
134_V139_L0.7130.82
25_F37_P0.7100.82
15_V136_V0.7060.81
118_L121_A0.7050.81
106_T110_V0.6970.81
26_L38_P0.6870.80
122_L125_A0.6870.80
125_A132_L0.6820.79
9_T12_A0.6820.79
60_G74_G0.6800.79
74_G78_V0.6770.79
22_P121_A0.6750.78
88_L95_P0.6750.78
116_P129_G0.6720.78
68_L105_L0.6710.78
30_L130_A0.6660.77
135_L138_W0.6550.76
46_G137_V0.6530.76
56_A68_L0.6500.76
4_R7_L0.6470.75
85_S89_G0.6470.75
121_A129_G0.6460.75
35_L137_V0.6430.75
50_V53_L0.6410.75
74_G77_L0.6390.74
75_L79_G0.6390.74
102_L109_P0.6370.74
64_S109_P0.6320.74
34_L68_L0.6310.74
5_L12_A0.6100.71
16_A24_P0.6080.71
85_S98_G0.6030.70
12_A136_V0.6020.70
88_L94_S0.6020.70
124_L128_V0.5960.69
105_L111_V0.5950.69
11_L20_G0.5930.69
55_L59_A0.5930.69
72_L75_L0.5900.69
39_P99_T0.5900.69
66_L74_G0.5890.68
17_Y25_F0.5870.68
87_Y94_S0.5870.68
77_L103_I0.5870.68
61_L108_I0.5850.68
2_I7_L0.5830.68
117_A124_L0.5820.67
81_L85_S0.5720.66
101_L133_A0.5710.66
75_L84_L0.5690.66
46_G54_A0.5670.65
57_A104_G0.5660.65
126_L129_G0.5660.65
43_L52_V0.5630.65
91_R94_S0.5610.65
7_L10_T0.5600.65
22_P58_G0.5570.64
57_A126_L0.5490.63
26_L126_L0.5420.62
53_L56_A0.5420.62
120_L124_L0.5410.62
5_L24_P0.5410.62
73_V84_L0.5370.61
124_L135_L0.5340.61
101_L105_L0.5340.61
80_L128_V0.5290.60
45_A115_S0.5290.60
63_L85_S0.5280.60
13_L18_G0.5260.60
106_T113_S0.5220.59
33_L99_T0.5200.59
107_L121_A0.5200.59
121_A126_L0.5190.59
80_L108_I0.5170.58
25_F29_V0.5090.57
84_L129_G0.5090.57
103_I137_V0.5080.57
117_A125_A0.5030.56
24_P45_A0.5000.56
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1hq1A 1 0.2429 1.8 0.93 Contact Map
2jqeA 1 0.2857 1.7 0.93 Contact Map
2k44A 1 0.0714 1.3 0.934 Contact Map
2mc7A 1 0.2143 1.2 0.937 Contact Map
3k3fA 3 0.8143 1.1 0.938 Contact Map
2mpnA 2 0.3357 1 0.939 Contact Map
4f35D 2 0.6571 1 0.94 Contact Map
2ksfA 1 0.7 1 0.941 Contact Map
4wgvA 2 0.9714 0.8 0.944 Contact Map
4p02A 1 0.6929 0.8 0.945 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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