GREMLIN Database
DUF2949 - Protein of unknown function (DUF2949)
PFAM: PF11165 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 56 (55)
Sequences: 898 (552)
Seq/√Len: 74.4
META: 0.744

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
43_I51_I5.3581.00
9_Q16_E2.6261.00
6_R10_E2.0581.00
22_A36_V1.7621.00
15_S42_L1.5990.99
31_G43_I1.5870.99
7_F50_Q1.5580.99
28_Q39_Q1.5100.99
4_L51_I1.4640.99
48_L52_F1.4510.99
15_S18_S1.3970.99
7_F10_E1.3920.98
2_S20_A1.3790.98
34_P40_Y1.3540.98
11_E19_I1.3440.98
22_A33_L1.3260.98
7_F12_L1.3010.98
2_S17_S1.2820.97
42_L53_D1.2600.97
40_Y48_L1.2420.97
18_S44_T1.2310.97
42_L46_E1.2240.97
34_P38_W1.2040.96
14_L47_Q1.1900.96
4_L54_W1.1610.95
49_D53_D1.1480.95
46_E49_D1.0890.93
3_R6_R1.0750.93
8_L19_I1.0480.92
7_F34_P1.0310.91
5_I19_I0.9940.90
22_A26_S0.9430.87
6_R39_Q0.9310.87
22_A47_Q0.9300.87
25_H56_E0.9220.86
4_L23_L0.9070.85
8_L53_D0.8970.85
4_L34_P0.8840.84
22_A31_G0.8780.83
13_G44_T0.8400.81
3_R21_L0.8380.80
22_A39_Q0.8280.80
24_R29_E0.8170.79
26_S42_L0.8140.78
27_E31_G0.8110.78
4_L25_H0.7720.75
29_E32_P0.7690.74
25_H52_F0.7590.73
12_L51_I0.7500.73
22_A45_L0.7450.72
42_L45_L0.7380.71
13_G33_L0.7350.71
9_Q19_I0.7150.69
16_E56_E0.7030.68
34_P48_L0.7020.67
11_E38_W0.6990.67
17_S20_A0.6830.65
14_L18_S0.6680.64
21_L24_R0.6650.63
13_G16_E0.6580.62
2_S6_R0.6320.59
20_A53_D0.6290.59
9_Q50_Q0.6130.57
21_L29_E0.5990.55
8_L12_L0.5880.54
30_P45_L0.5870.54
3_R12_L0.5840.53
35_M45_L0.5830.53
44_T49_D0.5800.53
51_I54_W0.5780.53
16_E20_A0.5720.52
25_H47_Q0.5610.51
2_S11_E0.5510.49
7_F41_G0.5470.49
4_L22_A0.5310.47
39_Q55_L0.5300.47
49_D52_F0.5280.46
44_T53_D0.5270.46
25_H40_Y0.5190.45
27_E43_I0.5140.45
26_S36_V0.5050.44
34_P49_D0.5000.43
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2d28C 1 0.9464 80.9 0.779 Contact Map
2w84A 1 0.5536 17.1 0.86 Contact Map
3ff5A 2 0.4464 15.1 0.863 Contact Map
2pi2A 1 0 14.8 0.864 Contact Map
3mvaO 1 0.7857 8.8 0.877 Contact Map
4iuwA 1 1 8.1 0.879 Contact Map
4fp9B 2 0.7321 7.8 0.88 Contact Map
3eyiA 1 0.9821 6.6 0.884 Contact Map
4p5wA 2 0.7857 6.4 0.884 Contact Map
4dbgB 1 0.6429 6.2 0.885 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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