GREMLIN Database
DUF2948 - Protein of unknown function (DUF2948)
PFAM: PF11164 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 139 (138)
Sequences: 5346 (3219)
Seq/√Len: 274.0
META: 0.917

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
15_S90_A4.0331.00
31_L34_E3.2901.00
102_E114_R2.7751.00
18_L41_L2.7011.00
73_K114_R2.6671.00
88_L105_L2.5941.00
94_E104_T2.5451.00
37_F115_L2.3371.00
93_F101_G2.2931.00
102_E116_E2.2921.00
104_T112_A2.2841.00
45_R58_E2.2791.00
36_R67_D2.1701.00
66_F122_A2.1301.00
28_I37_F2.1151.00
87_S108_A2.0491.00
35_R70_L1.8801.00
68_R121_E1.8471.00
81_D84_A1.8151.00
57_Y136_R1.8031.00
92_E106_T1.7731.00
23_V107_F1.7521.00
24_K27_D1.7311.00
66_F103_V1.7171.00
42_N61_R1.6881.00
71_A116_E1.6731.00
35_R68_R1.6091.00
88_L107_F1.5741.00
75_R112_A1.4951.00
70_L118_E1.4731.00
37_F113_I1.4161.00
9_E12_A1.4151.00
74_S79_R1.4021.00
44_F57_Y1.3881.00
40_L63_A1.3791.00
23_V41_L1.3551.00
103_V120_I1.3441.00
69_V117_V1.3371.00
37_F72_V1.3351.00
69_V115_L1.3351.00
6_L121_E1.3311.00
5_A14_I1.3221.00
21_A41_L1.3091.00
57_Y133_T1.2751.00
92_E104_T1.2511.00
23_V86_L1.2441.00
65_R123_E1.2431.00
68_R119_C1.2411.00
48_D58_E1.2281.00
78_D81_D1.2241.00
106_T112_A1.2221.00
73_K116_E1.2211.00
104_T114_R1.1881.00
93_F117_V1.1541.00
39_L64_L1.1521.00
103_V117_V1.1361.00
66_F115_L1.1261.00
23_V39_L1.1101.00
45_R48_D1.1031.00
25_V77_I1.0761.00
25_V86_L1.0721.00
95_P98_A1.0601.00
67_D121_E1.0481.00
28_I113_I1.0471.00
45_R60_V1.0411.00
49_A57_Y1.0361.00
72_V115_L1.0271.00
8_A12_A1.0091.00
22_V85_V1.0001.00
101_G117_V0.9911.00
96_G116_E0.9821.00
84_A111_G0.9801.00
63_A127_L0.9781.00
86_L107_F0.9611.00
70_L116_E0.9491.00
128_G131_W0.9481.00
90_A106_T0.9461.00
24_K85_V0.9451.00
74_S77_I0.9411.00
31_L38_A0.9401.00
47_E60_V0.9381.00
25_V79_R0.9351.00
68_R118_E0.9321.00
60_V130_P0.9231.00
91_I103_V0.9021.00
2_K125_A0.8971.00
17_H47_E0.8871.00
50_E55_R0.8821.00
48_D56_P0.8811.00
58_E130_P0.8761.00
62_S124_L0.8701.00
11_L122_A0.8681.00
78_D82_K0.8631.00
14_I122_A0.8501.00
40_L127_L0.8441.00
96_G100_A0.8391.00
42_N59_R0.8311.00
44_F89_L0.8180.99
94_E102_E0.8140.99
22_V42_N0.8070.99
6_L68_R0.8030.99
8_A95_P0.7970.99
79_R82_K0.7970.99
133_T136_R0.7960.99
31_L36_R0.7890.99
93_F99_P0.7870.99
48_D55_R0.7710.99
103_V122_A0.7660.99
77_I111_G0.7590.99
7_D12_A0.7530.99
42_N85_V0.7520.99
24_K61_R0.7510.99
77_I107_F0.7500.99
66_F69_V0.7500.99
38_A65_R0.7460.99
27_D61_R0.7400.99
29_A38_A0.7350.99
65_R125_A0.7330.99
60_V128_G0.7330.99
17_H45_R0.7270.99
89_L108_A0.7240.99
7_D10_D0.7240.99
26_G82_K0.7200.99
118_E121_E0.7200.99
66_F105_L0.7190.99
84_A110_G0.7150.99
38_A67_D0.7150.99
29_A40_L0.7140.98
18_L88_L0.7140.98
132_P135_A0.7040.98
61_R131_W0.6950.98
45_R65_R0.6940.98
97_E100_A0.6940.98
25_V78_D0.6930.98
45_R130_P0.6800.98
32_P71_A0.6750.98
41_L64_L0.6740.98
100_A116_E0.6640.98
22_V61_R0.6640.98
33_K70_L0.6590.97
25_V82_K0.6580.97
42_N131_W0.6540.97
107_F113_I0.6490.97
46_W59_R0.6370.97
74_S113_I0.6350.97
58_E132_P0.6350.97
52_G56_P0.6310.97
36_R65_R0.6250.97
52_G55_R0.6230.96
50_E53_G0.6220.96
41_L88_L0.6210.96
5_A122_A0.6210.96
39_L105_L0.6210.96
76_G110_G0.6200.96
105_L113_I0.6170.96
40_L61_R0.6160.96
19_Q44_F0.6150.96
96_G102_E0.6090.96
78_D84_A0.6080.96
19_Q59_R0.6070.96
68_R99_P0.6030.96
6_L17_H0.5990.96
73_K102_E0.5930.95
91_I105_L0.5920.95
26_G83_D0.5910.95
47_E50_E0.5880.95
23_V28_I0.5870.95
28_I74_S0.5860.95
46_W87_S0.5850.95
12_A92_E0.5840.95
63_A125_A0.5790.95
128_G133_T0.5790.95
127_L131_W0.5740.94
19_Q46_W0.5730.94
50_E58_E0.5680.94
25_V84_A0.5680.94
20_D44_F0.5640.94
119_C123_E0.5620.94
11_L120_I0.5610.94
22_V87_S0.5590.94
30_Y36_R0.5590.94
67_D123_E0.5570.94
77_I84_A0.5520.93
20_D59_R0.5500.93
88_L91_I0.5500.93
20_D89_L0.5400.92
99_P119_C0.5300.92
33_K79_R0.5300.92
95_P100_A0.5280.92
57_Y60_V0.5280.92
107_F111_G0.5200.91
12_A16_A0.5200.91
23_V27_D0.5170.91
5_A11_L0.5160.91
38_A125_A0.5150.91
28_I107_F0.5130.90
18_L62_S0.5110.90
8_A11_L0.5090.90
30_Y125_A0.5080.90
49_A136_R0.5070.90
40_L125_A0.5060.90
77_I86_L0.5050.90
22_V108_A0.5040.90
93_F100_A0.5020.90
64_L124_L0.5000.89
7_D11_L0.5000.89
129_E136_R0.5000.89
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3obyA 1 0.6906 4.5 0.951 Contact Map
2rm4A 1 0.3309 3.7 0.953 Contact Map
4aw7A 1 0.8058 3.5 0.954 Contact Map
2kfdA 1 0.3741 3.4 0.954 Contact Map
3lheA 1 0.3525 3.4 0.954 Contact Map
4a8cA 5 0.295 3 0.955 Contact Map
2iwaA 1 0.4676 3 0.955 Contact Map
3a1jC 1 0.8705 2.9 0.956 Contact Map
1ybxA 2 0.2662 2.6 0.956 Contact Map
4jnhA 2 0.1511 2.5 0.957 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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