GREMLIN Database
DUF2946 - Protein of unknown function (DUF2946)
PFAM: PF11162 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 116 (115)
Sequences: 5030 (4023)
Seq/√Len: 375.1
META: 0.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
107_W112_P3.5911.00
15_P19_Q3.0911.00
16_L19_Q2.8331.00
107_W111_A2.3671.00
108_P112_P2.3551.00
11_Q18_S2.2331.00
108_P111_A2.2171.00
107_W110_A2.1561.00
41_A44_A2.0711.00
36_S40_A2.0371.00
15_P18_S1.9691.00
43_A46_A1.8901.00
11_Q19_Q1.8681.00
15_P66_Y1.8321.00
36_S39_G1.8101.00
109_P112_P1.7711.00
14_A18_S1.7701.00
24_A27_A1.6811.00
10_L14_A1.6431.00
75_A78_P1.5581.00
21_A25_A1.5331.00
63_H66_Y1.5301.00
34_I37_A1.5271.00
46_A49_A1.4681.00
42_A45_A1.4521.00
113_R116_P1.4421.00
29_L32_A1.3961.00
102_P107_W1.3961.00
33_E39_G1.3611.00
102_P105_P1.3431.00
3_L8_L1.3321.00
105_P108_P1.3221.00
102_P108_P1.3011.00
4_A7_A1.2571.00
73_A76_L1.2571.00
37_A40_A1.2331.00
41_A45_A1.2291.00
20_A24_A1.2061.00
14_A17_V1.1931.00
51_S54_S1.1701.00
83_L86_P1.1641.00
105_P109_P1.1511.00
14_A63_H1.1421.00
10_L18_S1.1401.00
104_L107_W1.0921.00
44_A47_A1.0861.00
47_A50_G1.0851.00
85_L88_A1.0851.00
68_S72_H1.0841.00
96_L104_L1.0731.00
77_P80_A1.0641.00
32_A35_C1.0371.00
63_H68_S1.0351.00
76_L79_P1.0181.00
103_P112_P0.9971.00
23_A26_A0.9901.00
98_L101_P0.9781.00
28_P31_W0.9761.00
89_A93_A0.9701.00
98_L104_L0.9691.00
54_S57_H0.9581.00
26_A31_W0.9561.00
33_E36_S0.9561.00
94_P98_L0.9481.00
104_L108_P0.9401.00
106_A112_P0.9351.00
103_P107_W0.9331.00
98_L102_P0.9281.00
65_P68_S0.9201.00
5_L8_L0.9131.00
13_L18_S0.9031.00
22_A25_A0.8991.00
20_A23_A0.8981.00
57_H62_E0.8961.00
18_S63_H0.8761.00
73_A78_P0.8731.00
19_Q63_H0.8711.00
56_A59_A0.8691.00
55_P58_A0.8641.00
50_G53_P0.8611.00
101_P104_L0.8581.00
8_L12_A0.8551.00
93_A96_L0.8551.00
97_F102_P0.8531.00
17_V66_Y0.8481.00
65_P69_L0.8481.00
25_A28_P0.8401.00
100_A108_P0.8381.00
58_A62_E0.8341.00
103_P108_P0.8311.00
91_A95_P0.8301.00
35_C40_A0.8291.00
34_I40_A0.8291.00
42_A46_A0.8261.00
86_P90_A0.8171.00
11_Q16_L0.8131.00
105_P112_P0.8131.00
12_A18_S0.8101.00
41_A46_A0.8101.00
2_W6_L0.8001.00
106_A109_P0.7901.00
104_L111_A0.7891.00
41_A48_A0.7861.00
62_E68_S0.7781.00
29_L33_E0.7691.00
5_L11_Q0.7691.00
46_A51_S0.7661.00
84_L87_A0.7651.00
4_A66_Y0.7621.00
56_A60_H0.7571.00
86_P94_P0.7561.00
57_H60_H0.7511.00
104_L109_P0.7491.00
86_P89_A0.7431.00
92_R95_P0.7421.00
6_L23_A0.7241.00
7_A15_P0.7241.00
75_A79_P0.7241.00
27_A34_I0.7161.00
104_L112_P0.7151.00
31_W40_A0.7151.00
12_A16_L0.7070.99
10_L66_Y0.7050.99
97_F106_A0.6990.99
91_A96_L0.6900.99
100_A103_P0.6620.99
103_P106_A0.6610.99
11_Q17_V0.6600.99
27_A30_L0.6580.99
85_L89_A0.6540.99
4_A10_L0.6500.99
8_L11_Q0.6470.99
78_P82_A0.6450.99
18_S67_C0.6400.99
45_A54_S0.6350.99
83_L87_A0.6330.99
13_L16_L0.6330.99
30_L34_I0.6300.99
91_A94_P0.6280.99
94_P97_F0.6250.99
92_R100_A0.6240.99
14_A19_Q0.6240.99
35_C39_G0.6220.99
23_A27_A0.6200.99
4_A11_Q0.6090.99
95_P99_A0.6060.98
83_L88_A0.6050.98
29_L34_I0.6020.98
82_A85_L0.6020.98
11_Q15_P0.5910.98
89_A94_P0.5820.98
93_A97_F0.5790.98
9_L12_A0.5780.98
30_L40_A0.5710.98
2_W5_L0.5660.98
81_A89_A0.5650.98
32_A37_A0.5620.97
106_A110_A0.5590.97
70_L74_P0.5540.97
82_A88_A0.5540.97
19_Q62_E0.5510.97
30_L33_E0.5510.97
91_A97_F0.5430.97
26_A29_L0.5420.97
80_A86_P0.5380.97
97_F100_A0.5220.96
31_W35_C0.5150.96
66_Y70_L0.5150.96
97_F105_P0.5140.96
31_W34_I0.5130.96
18_S65_P0.5000.95
103_P110_A0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2qjyB 1 0.2241 2.8 0.893 Contact Map
3cx5D 2 0.3362 2.6 0.894 Contact Map
2m1jA 1 0.1983 2.4 0.897 Contact Map
1z65A 1 0.1983 2.4 0.897 Contact Map
3dl8E 1 0.1724 2.1 0.9 Contact Map
3wwqC 1 0.3362 2 0.9 Contact Map
3qxfA 1 0.2328 1.7 0.904 Contact Map
2xq2A 2 0.2069 1.6 0.906 Contact Map
2jlnA 1 0.2759 1.6 0.906 Contact Map
2i68A 2 0.1552 1.5 0.908 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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