GREMLIN Database
DUF2939 - Protein of unknown function (DUF2939)
PFAM: PF11159 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 94 (91)
Sequences: 4247 (3190)
Seq/√Len: 334.4
META: 0.917

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
19_L31_L3.6051.00
43_S47_Q2.7911.00
8_Y11_S2.5461.00
20_R24_R2.1391.00
32_E37_F2.0851.00
18_R34_Y2.0651.00
76_A80_P2.0321.00
45_K82_V1.9121.00
18_R30_A1.9071.00
87_T90_G1.8091.00
11_S15_A1.7691.00
39_A43_S1.7661.00
28_A32_E1.7471.00
51_A56_R1.7341.00
14_Y18_R1.6791.00
19_L34_Y1.6771.00
27_D30_A1.6641.00
7_A11_S1.6411.00
30_A34_Y1.5121.00
56_R59_K1.5101.00
21_S25_A1.4681.00
37_F47_Q1.4381.00
76_A79_D1.4311.00
15_A18_R1.4071.00
5_L9_A1.4051.00
42_E46_A1.3921.00
6_A10_A1.3651.00
90_G93_A1.3381.00
17_Y21_S1.3361.00
10_A14_Y1.3281.00
22_A30_A1.3161.00
70_G73_L1.2981.00
39_A42_E1.2431.00
29_A32_E1.2281.00
14_Y17_Y1.2241.00
15_A34_Y1.2151.00
45_K79_D1.1881.00
10_A13_Y1.1741.00
54_L58_G1.1601.00
40_L43_S1.1551.00
36_D39_A1.1331.00
42_E45_K1.1231.00
21_S24_R1.1171.00
11_S14_Y1.0741.00
31_L92_A1.0651.00
9_A13_Y1.0331.00
25_A30_A1.0171.00
63_D66_L1.0091.00
78_A82_V0.9961.00
79_D83_D0.9871.00
41_R83_D0.9681.00
38_P42_E0.9591.00
4_L8_Y0.9531.00
37_F41_R0.9451.00
31_L35_V0.9391.00
75_P79_D0.9301.00
72_A76_A0.9281.00
4_L7_A0.9221.00
70_G75_P0.9081.00
45_K83_D0.9041.00
22_A31_L0.8871.00
31_L37_F0.8851.00
49_V52_L0.8821.00
51_A55_R0.8811.00
28_A89_E0.8671.00
13_Y17_Y0.8531.00
49_V79_D0.8461.00
57_A60_D0.8431.00
72_A75_P0.8431.00
44_L82_V0.8231.00
54_L60_D0.8181.00
74_A77_L0.8171.00
41_R45_K0.8041.00
72_A89_E0.8031.00
7_A14_Y0.7991.00
54_L57_A0.7961.00
56_R60_D0.7891.00
38_P41_R0.7821.00
9_A14_Y0.7691.00
74_A78_A0.7651.00
26_G92_A0.7561.00
59_K71_A0.7480.99
44_L47_Q0.7360.99
41_R47_Q0.7310.99
17_Y20_R0.7280.99
70_G74_A0.7210.99
49_V78_A0.7160.99
81_A86_V0.7090.99
45_K52_L0.7050.99
12_P15_A0.6920.99
46_A50_A0.6800.99
40_L47_Q0.6770.99
59_K63_D0.6710.99
71_A75_P0.6570.99
85_L90_G0.6510.99
26_G89_E0.6450.98
79_D82_V0.6330.98
23_A37_F0.6280.98
63_D67_A0.6270.98
80_P84_A0.6240.98
55_R58_G0.6240.98
58_G61_P0.6180.98
8_Y13_Y0.6150.98
26_G34_Y0.6110.98
5_L8_Y0.6070.98
70_G78_A0.6060.98
47_Q51_A0.5990.98
78_A81_A0.5980.98
55_R59_K0.5860.97
41_R79_D0.5830.97
65_P69_L0.5690.97
22_A27_D0.5690.97
13_Y19_L0.5660.97
31_L87_T0.5630.96
18_R21_S0.5630.96
86_V90_G0.5610.96
17_Y91_L0.5570.96
15_A19_L0.5570.96
50_A63_D0.5560.96
87_T91_L0.5520.96
69_L72_A0.5510.96
84_A88_P0.5500.96
37_F43_S0.5410.96
35_V40_L0.5400.96
65_P68_A0.5390.96
4_L10_A0.5390.96
45_K48_L0.5390.96
75_P91_L0.5300.95
57_A61_P0.5290.95
6_A17_Y0.5270.95
64_N68_A0.5200.95
18_R22_A0.5150.94
16_L20_R0.5140.94
52_L84_A0.5100.94
36_D71_A0.5040.94
20_R23_A0.5000.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ofdA 1 0.9468 6.6 0.877 Contact Map
3k7cA 2 0.8723 4.5 0.886 Contact Map
3qnqA 2 0.3511 3.9 0.89 Contact Map
1dm5A 4 0.7872 3.8 0.891 Contact Map
1ea0A 1 0.9043 3 0.896 Contact Map
4pwuA 4 0.7979 2.8 0.898 Contact Map
2jy0A 1 0.1596 2.8 0.898 Contact Map
4bxhA 3 0.9043 2.7 0.899 Contact Map
1yiiA 1 0.7766 2.6 0.899 Contact Map
1n00A 1 0.8191 2.6 0.899 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0051 seconds.