GREMLIN Database
DUF2938 - Protein of unknown function (DUF2938)
PFAM: PF11158 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 150 (148)
Sequences: 3046 (2114)
Seq/√Len: 173.8
META: 0.838

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
36_L65_A4.0171.00
37_G61_L3.4521.00
37_G55_V3.1091.00
77_L97_F3.1021.00
6_G146_A2.9781.00
103_V107_F2.8571.00
39_M44_F2.7621.00
48_S51_A2.7461.00
119_A128_A2.6561.00
78_V86_L2.6061.00
38_H52_A2.4791.00
30_A59_L2.4711.00
126_A129_R2.4391.00
124_N127_Q2.0891.00
81_A97_F2.0581.00
122_T125_P1.9751.00
46_H49_I1.9341.00
65_A69_I1.8931.00
48_S52_A1.8711.00
106_F132_S1.7901.00
107_F118_A1.7561.00
99_I137_T1.7181.00
11_M29_Y1.7131.00
11_M15_A1.6771.00
19_K26_S1.6501.00
98_G102_V1.5861.00
39_M109_M1.5811.00
17_L21_L1.5801.00
128_A132_S1.5691.00
11_M135_T1.5651.00
135_T138_V1.5441.00
3_I86_L1.5431.00
7_A143_L1.5411.00
131_R135_T1.5211.00
106_F129_R1.4991.00
107_F117_I1.4891.00
98_G101_T1.4741.00
27_L73_F1.4711.00
10_V14_W1.4531.00
18_L21_L1.4421.00
83_L86_L1.4351.00
18_L131_R1.4201.00
28_N59_L1.3471.00
9_L13_L1.3281.00
8_T70_G1.3251.00
15_A26_S1.3141.00
126_A130_L1.3101.00
41_R55_V1.2861.00
76_L104_A1.2611.00
109_M113_M1.2431.00
74_A143_L1.2381.00
18_L22_F1.2211.00
60_A64_I1.2191.00
115_A122_T1.2141.00
83_L87_R1.2021.00
104_A109_M1.2021.00
64_I68_A1.1991.00
73_F104_A1.1621.00
100_A103_V1.1361.00
11_M27_L1.1351.00
72_A139_F1.1281.00
76_L97_F1.1021.00
14_W138_V1.1011.00
25_P28_N1.0951.00
77_L93_P1.0831.00
45_R112_A1.0751.00
15_A32_V1.0671.00
13_L17_L1.0661.00
81_A93_P1.0531.00
84_D87_R1.0340.99
124_N131_R1.0170.99
73_F135_T1.0140.99
73_F97_F1.0070.99
124_N128_A1.0020.99
102_V133_L1.0000.99
77_L85_W0.9870.99
32_V68_A0.9790.99
37_G40_P0.9750.99
34_R58_E0.9660.99
50_A115_A0.9440.99
49_I52_A0.9300.99
73_F98_G0.9200.99
97_F100_A0.9120.99
38_H53_P0.9060.99
102_V132_S0.9000.98
4_G8_T0.8970.98
18_L24_I0.8940.98
139_F143_L0.8870.98
29_Y135_T0.8790.98
127_Q131_R0.8720.98
36_L39_M0.8640.98
106_F128_A0.8560.98
85_W93_P0.8500.98
5_I71_I0.8420.98
122_T128_A0.8370.98
3_I78_V0.8270.97
82_G85_W0.8220.97
91_L95_L0.8140.97
81_A96_L0.8070.97
78_V81_A0.8050.97
85_W89_P0.7990.97
28_N48_S0.7910.97
71_I74_A0.7900.97
46_H52_A0.7810.96
40_P43_R0.7800.96
36_L40_P0.7790.96
91_L141_L0.7760.96
102_V106_F0.7750.96
38_H55_V0.7730.96
27_L32_V0.7710.96
140_G145_L0.7710.96
20_R23_G0.7670.96
57_G60_A0.7660.96
110_Q119_A0.7640.96
94_A143_L0.7620.96
38_H46_H0.7490.95
69_I104_A0.7460.95
131_R134_V0.7380.95
15_A27_L0.7360.95
47_A51_A0.7350.95
125_P128_A0.7320.95
10_V145_L0.7230.94
97_F104_A0.7230.94
102_V139_F0.7190.94
13_L16_L0.7180.94
75_A92_L0.7170.94
29_Y73_F0.7110.94
105_P109_M0.7080.94
18_L134_V0.7040.94
63_W73_F0.7040.94
41_R61_L0.6990.93
85_W118_A0.6930.93
75_A86_L0.6910.93
48_S115_A0.6860.93
31_L50_A0.6740.92
18_L138_V0.6700.92
27_L101_T0.6580.91
80_L97_F0.6560.91
22_F25_P0.6530.91
10_V138_V0.6530.91
40_P61_L0.6480.90
14_W18_L0.6470.90
31_L37_G0.6450.90
4_G7_A0.6450.90
19_K27_L0.6440.90
125_P129_R0.6410.90
8_T15_A0.6390.90
132_S135_T0.6350.89
113_M134_V0.6350.89
144_Y148_L0.6320.89
56_R59_L0.6320.89
120_S129_R0.6300.89
130_L134_V0.6240.89
118_A129_R0.6210.88
141_L145_L0.6200.88
28_N31_L0.6200.88
41_R121_R0.6180.88
11_M142_G0.6170.88
15_A134_V0.6170.88
99_I133_L0.6160.88
11_M138_V0.6150.88
62_G89_P0.6150.88
19_K24_I0.6090.87
32_V105_P0.6070.87
13_L56_R0.6050.87
145_L148_L0.6030.87
105_P132_S0.6030.87
43_R47_A0.6010.87
7_A10_V0.6010.87
82_G147_A0.5900.86
32_V73_F0.5860.85
119_A132_S0.5850.85
22_F106_F0.5850.85
77_L147_A0.5830.85
104_A108_I0.5830.85
3_I146_A0.5820.85
18_L135_T0.5760.84
19_K28_N0.5740.84
95_L137_T0.5710.84
8_T67_Y0.5710.84
77_L83_L0.5690.84
19_K22_F0.5690.84
143_L146_A0.5670.84
135_T139_F0.5620.83
46_H110_Q0.5610.83
44_F50_A0.5600.83
29_Y32_V0.5580.83
127_Q134_V0.5580.83
15_A113_M0.5570.82
84_D96_L0.5570.82
85_W147_A0.5550.82
71_I75_A0.5550.82
16_L20_R0.5540.82
93_P147_A0.5540.82
3_I77_L0.5520.82
18_L26_S0.5450.81
77_L81_A0.5450.81
77_L82_G0.5430.81
15_A107_F0.5410.81
65_A106_F0.5400.80
91_L140_G0.5390.80
140_G143_L0.5390.80
41_R96_L0.5340.80
24_I131_R0.5280.79
117_I120_S0.5260.79
26_S117_I0.5220.78
134_V143_L0.5220.78
27_L131_R0.5180.78
10_V72_A0.5140.77
15_A135_T0.5130.77
108_I112_A0.5090.76
9_L14_W0.5090.76
138_V141_L0.5090.76
90_T93_P0.5070.76
54_P83_L0.5060.76
35_W49_I0.5050.76
77_L146_A0.5050.76
17_L22_F0.5040.76
113_M131_R0.5040.76
13_L141_L0.5030.76
56_R60_A0.5030.76
37_G57_G0.5000.75
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2kncB 1 0.2333 1.9 0.96 Contact Map
4o6yA 2 0.9333 1.8 0.961 Contact Map
2iizA 2 0.36 1.6 0.962 Contact Map
2mawA 1 0.6067 1.5 0.963 Contact Map
1my6A 2 0.3267 1.1 0.966 Contact Map
5a63D 1 0.48 1 0.966 Contact Map
2kluA 1 0.1933 1 0.966 Contact Map
4us3A 1 0.9267 1 0.967 Contact Map
1ma1A 4 0.3333 1 0.967 Contact Map
2rcvA 2 0.3267 1 0.967 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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