GREMLIN Database
DUF2937 - Protein of unknown function (DUF2937)
PFAM: PF11157 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 162 (157)
Sequences: 1692 (1365)
Seq/√Len: 109.0
META: 0.806

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
63_R69_D3.5641.00
46_D57_R3.3941.00
37_E85_R3.2681.00
65_L80_Q2.9651.00
64_Y72_F2.9371.00
46_D50_A2.6341.00
48_D78_S2.4731.00
67_S72_F2.4481.00
52_F74_A2.4371.00
22_E127_A2.3301.00
105_L137_Y2.2911.00
42_L83_V2.2761.00
35_L86_Y2.1471.00
38_L86_Y2.1131.00
56_D59_A2.1001.00
37_E40_R2.0591.00
36_D119_A2.0481.00
35_L93_L1.8851.00
125_E131_T1.8231.00
39_R90_S1.8141.00
30_R120_T1.7641.00
34_A37_E1.7581.00
51_R74_A1.7361.00
22_E25_Q1.7301.00
34_A119_A1.6971.00
48_D75_R1.6901.00
20_V24_A1.6661.00
11_L14_A1.6571.00
6_D10_G1.6521.00
42_L86_Y1.6241.00
86_Y90_S1.6151.00
61_I83_V1.6031.00
64_Y75_R1.5951.00
93_L97_Q1.5721.00
45_F60_L1.5581.00
54_L63_R1.5301.00
34_A116_I1.5281.00
155_L159_P1.4831.00
32_G36_D1.4711.00
39_R86_Y1.4561.00
25_Q29_Q1.4511.00
97_Q123_D1.4491.00
15_L130_L1.4231.00
151_L155_L1.3881.00
90_S94_A1.3821.00
112_A117_A1.3511.00
119_A122_A1.3291.00
47_A50_A1.3210.99
32_G123_D1.2750.99
75_R78_S1.2730.99
30_R34_A1.2650.99
64_Y76_G1.2220.99
34_A85_R1.2180.99
93_L123_D1.2160.99
32_G93_L1.2010.99
72_F76_G1.1990.99
10_G14_A1.1990.99
23_F121_W1.1950.99
100_G103_E1.1590.99
37_E41_V1.1360.98
104_R133_E1.1330.98
87_E91_A1.1240.98
116_I120_T1.1180.98
3_R6_D1.1130.98
35_L90_S1.1090.98
24_A28_R1.1070.98
58_E62_A1.1030.98
58_E80_Q1.0980.98
41_V60_L1.0740.98
65_L76_G1.0690.98
57_R60_L1.0680.98
44_G75_R1.0670.98
82_T86_Y1.0670.98
134_G138_A1.0630.98
29_Q32_G1.0500.97
45_F78_S1.0450.97
10_G142_F1.0450.97
99_A107_V1.0380.97
84_A87_E1.0290.97
141_G145_G1.0240.97
31_L92_A1.0230.97
62_A66_A1.0230.97
60_L75_R1.0230.97
71_F75_R1.0180.97
151_L154_A0.9870.96
129_P134_G0.9800.96
114_P117_A0.9750.96
34_A120_T0.9700.96
109_L112_A0.9560.95
150_E154_A0.9470.95
80_Q84_A0.9460.95
23_F117_A0.9450.95
92_A95_A0.9320.95
29_Q33_G0.9210.94
47_A51_R0.9050.94
64_Y71_F0.9030.94
94_A98_G0.8890.93
26_Q127_A0.8880.93
132_P136_V0.8790.93
22_E26_Q0.8750.93
14_A138_A0.8640.92
33_G36_D0.8590.92
117_A121_W0.8520.92
30_R36_D0.8490.92
64_Y78_S0.8450.91
23_F120_T0.8300.91
4_Y7_L0.8270.91
44_G48_D0.8270.91
135_L139_L0.8260.90
45_F75_R0.8220.90
48_D71_F0.8210.90
44_G82_T0.8200.90
7_L10_G0.8180.90
79_M82_T0.8130.90
14_A142_F0.8120.90
92_A107_V0.8090.90
94_A97_Q0.8000.89
125_E133_E0.7970.89
39_R43_A0.7960.89
38_L41_V0.7900.88
19_Q129_P0.7890.88
40_R76_G0.7870.88
146_W149_F0.7830.88
36_D39_R0.7770.88
44_G81_A0.7740.87
64_Y69_D0.7710.87
9_L13_G0.7690.87
42_L57_R0.7640.87
106_L110_R0.7610.86
156_L159_P0.7570.86
10_G17_G0.7400.85
152_L156_L0.7390.85
28_R96_L0.7380.85
41_V79_M0.7370.85
40_R115_E0.7310.84
114_P118_R0.7280.84
115_E118_R0.7270.84
107_V110_R0.7250.84
132_P140_A0.7240.84
77_E81_A0.7220.83
43_A47_A0.7210.83
68_A157_R0.7190.83
88_R113_D0.7150.83
153_L157_R0.7110.83
10_G146_W0.7100.82
155_L158_R0.7020.82
148_L153_L0.7010.82
50_A56_D0.6980.81
18_S138_A0.6930.81
2_R5_L0.6830.80
17_G141_G0.6830.80
98_G124_F0.6810.80
11_L88_R0.6780.79
67_S71_F0.6760.79
16_A20_V0.6740.79
8_A12_A0.6680.78
74_A77_E0.6680.78
102_F106_L0.6630.78
108_L116_I0.6630.78
8_A16_A0.6620.78
73_R76_G0.6550.77
35_L38_L0.6550.77
13_G145_G0.6520.77
136_V147_L0.6470.76
30_R113_D0.6420.76
33_G127_A0.6390.75
142_F149_F0.6310.74
24_A108_L0.6310.74
35_L42_L0.6300.74
75_R79_M0.6270.74
60_L71_F0.6240.74
5_L51_R0.6240.74
41_V78_S0.6230.74
88_R122_A0.6170.73
41_V82_T0.6060.71
45_F121_W0.5990.71
103_E132_P0.5990.71
63_R67_S0.5980.70
29_Q36_D0.5970.70
37_E119_A0.5960.70
17_G137_Y0.5930.70
54_L60_L0.5920.70
128_V138_A0.5910.70
94_A124_F0.5900.69
154_A157_R0.5890.69
44_G78_S0.5890.69
23_F26_Q0.5860.69
44_G47_A0.5850.69
22_E45_F0.5810.68
54_L59_A0.5800.68
60_L78_S0.5800.68
18_S22_E0.5800.68
90_S93_L0.5770.68
81_A115_E0.5750.67
77_E140_A0.5730.67
77_E84_A0.5660.66
8_A128_V0.5650.66
6_D149_F0.5650.66
91_A95_A0.5630.66
18_S134_G0.5600.65
33_G126_P0.5600.65
90_S97_Q0.5580.65
42_L46_D0.5570.65
61_I65_L0.5550.65
53_G56_D0.5470.64
152_L158_R0.5470.64
78_S82_T0.5460.64
28_R104_R0.5450.63
92_A112_A0.5450.63
140_A148_L0.5440.63
16_A122_A0.5420.63
52_F63_R0.5420.63
108_L112_A0.5410.63
16_A155_L0.5380.62
71_F82_T0.5370.62
92_A137_Y0.5370.62
105_L120_T0.5340.62
96_L108_L0.5310.61
130_L134_G0.5300.61
101_P104_R0.5270.61
151_L158_R0.5250.61
45_F79_M0.5230.60
77_E80_Q0.5180.60
12_A84_A0.5180.60
134_G141_G0.5170.59
88_R128_V0.5160.59
98_G103_E0.5160.59
53_G71_F0.5150.59
71_F78_S0.5140.59
28_R125_E0.5100.58
98_G109_L0.5070.58
149_F153_L0.5070.58
3_R7_L0.5050.58
26_Q126_P0.5050.58
52_F72_F0.5040.57
22_E30_R0.5000.57
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2l2tA 2 0.2407 40.4 0.923 Contact Map
2m20A 2 0.1975 39 0.923 Contact Map
2l9uA 2 0.216 38.2 0.924 Contact Map
2ks1B 1 0.2469 28.5 0.929 Contact Map
2kluA 1 0.2222 26 0.93 Contact Map
2jwaA 2 0.2531 22.1 0.932 Contact Map
4wl1A 3 0.642 21 0.933 Contact Map
1iijA 1 0.216 18.6 0.934 Contact Map
4hw9A 3 0.1975 12.3 0.94 Contact Map
4abxA 2 0.5062 8.2 0.944 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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