DUF2931 - PFAM28P - GREMLIN Contacts

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DUF2931 - Protein of unknown function (DUF2931)

PFAM:	PF11153	Sequences: WILLLLLLLLLTGCQSAKPKSKKNDPYFEWYLGFSAPKYYPVWVETGDVIDIDGKLDGIPPGGGSAGGWGERGGGGSGGPNKGKPLPDRIYVRWQSYVEKKFYEGKIDLPEEKIEKMFKPGYYDCRGGGKDYYDTIVVGLAPGGVVVVWLRGSGCGKPIEVGRGQAEEVPLGPYDGKSNGEYYREPYSEETKEYIKKKGIPYG	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	203 (199)
Sequences:	1260 (860)
Seq/√Len:	60.9
META:	0.494

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
101_K	168_E	8.278	1.00
139_G	149_W	4.006	1.00
189_E	192_K	3.894	1.00
147_V	163_R	2.866	1.00
188_S	191_T	2.768	1.00
69_W	149_W	2.480	1.00
89_R	108_D	2.450	1.00
178_S	181_E	2.373	1.00
93_R	104_E	2.346	1.00
188_S	192_K	2.188	1.00
189_E	193_E	2.062	1.00
121_G	133_Y	2.001	1.00
192_K	196_K	1.988	1.00
178_S	182_Y	1.942	1.00
186_P	192_K	1.939	1.00
190_E	193_E	1.936	1.00
89_R	106_K	1.892	1.00
179_N	182_Y	1.874	1.00
69_W	141_A	1.838	1.00
116_K	120_P	1.738	0.99
104_E	167_E	1.732	0.99
30_W	94_W	1.717	0.99
174_Y	178_S	1.691	0.99
111_E	115_E	1.658	0.99
145_V	163_R	1.655	0.99
13_G	20_K	1.650	0.99
179_N	183_Y	1.628	0.99
105_G	166_A	1.603	0.99
121_G	132_Y	1.583	0.99
194_Y	198_K	1.573	0.99
29_E	84_K	1.555	0.99
4_L	12_T	1.540	0.98
194_Y	199_G	1.529	0.98
18_K	21_S	1.518	0.98
175_D	178_S	1.516	0.98
168_E	171_L	1.487	0.98
3_L	8_L	1.468	0.98
186_P	190_E	1.460	0.98
3_L	19_P	1.441	0.98
49_V	90_I	1.435	0.98
186_P	191_T	1.425	0.97
112_E	116_K	1.417	0.97
58_G	61_P	1.410	0.97
191_T	195_I	1.410	0.97
28_F	115_E	1.406	0.97
74_G	78_G	1.394	0.97
37_P	103_Y	1.391	0.97
174_Y	177_K	1.380	0.97
168_E	172_G	1.378	0.97
13_G	18_K	1.371	0.97
17_A	21_S	1.362	0.97
31_Y	135_T	1.357	0.97
91_Y	106_K	1.356	0.97
28_F	114_I	1.350	0.96
61_P	67_G	1.347	0.96
173_P	176_G	1.338	0.96
109_L	114_I	1.328	0.96
59_I	62_G	1.327	0.96
36_A	42_V	1.319	0.96
169_V	172_G	1.317	0.96
195_I	199_G	1.269	0.95
191_T	198_K	1.260	0.95
195_I	198_K	1.259	0.95
187_Y	192_K	1.252	0.95
22_K	25_D	1.248	0.95
16_S	21_S	1.245	0.94
137_V	151_R	1.241	0.94
57_D	61_P	1.235	0.94
74_G	77_S	1.229	0.94
187_Y	190_E	1.226	0.94
15_Q	18_K	1.219	0.94
95_Q	100_K	1.214	0.94
26_P	119_K	1.206	0.93
8_L	17_A	1.201	0.93
6_L	12_T	1.200	0.93
141_A	160_E	1.191	0.93
141_A	149_W	1.181	0.93
171_L	175_D	1.165	0.92
42_V	99_E	1.158	0.92
35_S	70_G	1.146	0.92
180_G	183_Y	1.145	0.92
95_Q	99_E	1.141	0.91
63_G	75_G	1.135	0.91
112_E	115_E	1.133	0.91
118_F	121_G	1.130	0.91
178_S	184_R	1.122	0.91
86_L	114_I	1.109	0.90
186_P	189_E	1.102	0.90
15_Q	19_P	1.100	0.90
63_G	66_A	1.089	0.89
4_L	19_P	1.081	0.89
4_L	17_A	1.081	0.89
147_V	160_E	1.077	0.89
92_V	140_L	1.069	0.88
45_E	93_R	1.069	0.88
16_S	20_K	1.066	0.88
193_E	196_K	1.062	0.88
59_I	67_G	1.062	0.88
160_E	166_A	1.059	0.88
9_L	146_V	1.023	0.86
30_W	136_I	1.018	0.86
12_T	19_P	1.017	0.86
178_S	183_Y	1.015	0.86
95_Q	102_F	1.002	0.85
44_V	47_G	0.993	0.85
115_E	119_K	0.993	0.85
178_S	185_E	0.988	0.84
70_G	77_S	0.986	0.84
60_P	65_S	0.970	0.83
149_W	160_E	0.970	0.83
184_R	187_Y	0.968	0.83
91_Y	104_E	0.950	0.82
3_L	12_T	0.934	0.81
155_C	162_G	0.934	0.81
181_E	184_R	0.929	0.80
193_E	197_K	0.927	0.80
4_L	13_G	0.924	0.80
62_G	72_R	0.919	0.80
177_K	182_Y	0.917	0.79
30_W	118_F	0.915	0.79
3_L	10_L	0.912	0.79
30_W	142_P	0.909	0.79
3_L	7_L	0.899	0.78
34_F	74_G	0.897	0.78
37_P	139_G	0.896	0.78
124_D	128_G	0.894	0.78
179_N	184_R	0.892	0.78
157_K	164_G	0.891	0.77
180_G	184_R	0.888	0.77
163_R	166_A	0.884	0.77
59_I	90_I	0.883	0.77
52_I	88_D	0.883	0.77
73_G	76_G	0.881	0.77
123_Y	127_G	0.879	0.76
59_I	74_G	0.878	0.76
174_Y	179_N	0.877	0.76
96_S	99_E	0.871	0.76
141_A	145_V	0.870	0.76
56_L	59_I	0.869	0.76
63_G	67_G	0.869	0.76
9_L	18_K	0.865	0.75
54_G	108_D	0.865	0.75
81_N	84_K	0.865	0.75
13_G	19_P	0.863	0.75
155_C	159_I	0.862	0.75
136_I	139_G	0.861	0.75
50_I	88_D	0.859	0.75
160_E	164_G	0.858	0.75
4_L	20_K	0.847	0.74
7_L	16_S	0.836	0.73
67_G	74_G	0.831	0.72
17_A	20_K	0.831	0.72
42_V	102_F	0.830	0.72
18_K	22_K	0.828	0.72
86_L	150_L	0.828	0.72
60_P	75_G	0.823	0.72
168_E	188_S	0.822	0.72
49_V	85_P	0.821	0.71
49_V	54_G	0.818	0.71
9_L	19_P	0.816	0.71
124_D	127_G	0.816	0.71
176_G	180_G	0.815	0.71
94_W	140_L	0.811	0.71
16_S	22_K	0.811	0.71
169_V	188_S	0.804	0.70
69_W	74_G	0.802	0.70
58_G	76_G	0.802	0.70
44_V	51_D	0.786	0.68
57_D	63_G	0.786	0.68
8_L	16_S	0.785	0.68
114_I	117_M	0.781	0.68
65_S	140_L	0.780	0.68
17_A	22_K	0.780	0.68
72_R	76_G	0.772	0.67
182_Y	186_P	0.768	0.66
10_L	20_K	0.759	0.65
181_E	185_E	0.757	0.65
88_D	91_Y	0.753	0.65
150_L	159_I	0.751	0.65
184_R	188_S	0.747	0.64
33_G	135_T	0.740	0.63
10_L	17_A	0.736	0.63
166_A	172_G	0.729	0.62
27_Y	36_A	0.722	0.62
41_P	97_Y	0.719	0.61
31_Y	75_G	0.718	0.61
20_K	23_K	0.714	0.61
4_L	10_L	0.713	0.61
182_Y	188_S	0.709	0.60
51_D	55_K	0.707	0.60
17_A	23_K	0.697	0.59
87_P	144_G	0.696	0.59
13_G	16_S	0.690	0.58
169_V	189_E	0.682	0.57
6_L	16_S	0.682	0.57
3_L	16_S	0.677	0.57
122_Y	136_I	0.675	0.56
75_G	179_N	0.672	0.56
142_P	161_V	0.672	0.56
5_L	9_L	0.670	0.56
187_Y	191_T	0.664	0.55
16_S	23_K	0.663	0.55
50_I	91_Y	0.661	0.55
10_L	15_Q	0.660	0.55
166_A	171_L	0.660	0.55
10_L	90_I	0.659	0.55
168_E	192_K	0.659	0.55
191_T	199_G	0.659	0.55
172_G	176_G	0.658	0.54
45_E	95_Q	0.655	0.54
65_S	79_G	0.654	0.54
14_C	18_K	0.653	0.54
29_E	82_K	0.652	0.54
160_E	163_R	0.651	0.54
166_A	169_V	0.650	0.54
146_V	166_A	0.648	0.53
189_E	195_I	0.647	0.53
166_A	200_I	0.643	0.53
141_A	163_R	0.642	0.53
19_P	25_D	0.636	0.52
191_T	194_Y	0.635	0.52
114_I	150_L	0.629	0.51
62_G	65_S	0.626	0.51
5_L	10_L	0.625	0.51
69_W	75_G	0.624	0.51
146_V	164_G	0.621	0.50
4_L	7_L	0.616	0.50
122_Y	127_G	0.611	0.49
64_G	68_G	0.610	0.49
6_L	18_K	0.606	0.49
79_G	84_K	0.604	0.48
178_S	186_P	0.602	0.48
122_Y	132_Y	0.602	0.48
170_P	176_G	0.600	0.48
124_D	151_R	0.599	0.48
177_K	180_G	0.599	0.48
112_E	118_F	0.594	0.47
59_I	65_S	0.586	0.46
169_V	175_D	0.585	0.46
86_L	143_G	0.585	0.46
177_K	183_Y	0.584	0.46
143_G	160_E	0.584	0.46
21_S	25_D	0.583	0.46
112_E	121_G	0.583	0.46
185_E	189_E	0.583	0.46
155_C	158_P	0.583	0.46
98_V	195_I	0.582	0.46
57_D	62_G	0.579	0.46
119_K	123_Y	0.579	0.46
136_I	148_V	0.574	0.45
60_P	76_G	0.572	0.45
170_P	186_P	0.567	0.44
182_Y	185_E	0.565	0.44
32_L	84_K	0.563	0.44
183_Y	188_S	0.561	0.44
105_G	140_L	0.559	0.43
114_I	118_F	0.557	0.43
123_Y	133_Y	0.556	0.43
127_G	130_K	0.555	0.43
93_R	102_F	0.554	0.43
35_S	90_I	0.554	0.43
5_L	8_L	0.553	0.43
139_G	163_R	0.553	0.43
89_R	167_E	0.551	0.42
9_L	21_S	0.547	0.42
94_W	142_P	0.545	0.42
65_S	75_G	0.544	0.42
7_L	17_A	0.541	0.41
126_R	148_V	0.541	0.41
98_V	150_L	0.539	0.41
195_I	202_Y	0.539	0.41
100_K	140_L	0.538	0.41
95_Q	176_G	0.535	0.41
58_G	62_G	0.535	0.41
192_K	198_K	0.531	0.40
123_Y	130_K	0.530	0.40
175_D	183_Y	0.528	0.40
42_V	105_G	0.528	0.40
172_G	175_D	0.524	0.39
30_W	140_L	0.523	0.39
113_K	117_M	0.522	0.39
101_K	140_L	0.520	0.39
198_K	203_G	0.520	0.39
46_T	55_K	0.520	0.39
5_L	20_K	0.520	0.39
49_V	138_V	0.516	0.39
12_T	29_E	0.515	0.39
60_P	63_G	0.508	0.38
200_I	203_G	0.507	0.38
45_E	110_P	0.506	0.38
98_V	199_G	0.505	0.37
8_L	20_K	0.504	0.37
6_L	137_V	0.504	0.37
182_Y	192_K	0.504	0.37
113_K	116_K	0.504	0.37
187_Y	200_I	0.503	0.37
117_M	138_V	0.501	0.37
36_A	68_G	0.500	0.37

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3zbiC	1	0.1379	39.8	0.931	Contact Map
3f42A	4	0.4433	26	0.937	Contact Map
4jg9A	2	0.5616	11.5	0.947	Contact Map
4kkfA	1	0.1626	8.6	0.95	Contact Map
2vzsA	1	0.7537	5.8	0.954	Contact Map
4n91A	2	0.7143	5.2	0.954	Contact Map
1j8bA	2	0.4138	4	0.957	Contact Map
4pfbA	1	0.7635	3.8	0.957	Contact Map
1xrxA	3	0.1084	3.6	0.958	Contact Map
4ng7A	1	0.6995	3.6	0.958	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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