GREMLIN Database
DUF2931 - Protein of unknown function (DUF2931)
PFAM: PF11153 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 203 (199)
Sequences: 1260 (860)
Seq/√Len: 60.9
META: 0.494

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
101_K168_E8.2781.00
139_G149_W4.0061.00
189_E192_K3.8941.00
147_V163_R2.8661.00
188_S191_T2.7681.00
69_W149_W2.4801.00
89_R108_D2.4501.00
178_S181_E2.3731.00
93_R104_E2.3461.00
188_S192_K2.1881.00
189_E193_E2.0621.00
121_G133_Y2.0011.00
192_K196_K1.9881.00
178_S182_Y1.9421.00
186_P192_K1.9391.00
190_E193_E1.9361.00
89_R106_K1.8921.00
179_N182_Y1.8741.00
69_W141_A1.8381.00
116_K120_P1.7380.99
104_E167_E1.7320.99
30_W94_W1.7170.99
174_Y178_S1.6910.99
111_E115_E1.6580.99
145_V163_R1.6550.99
13_G20_K1.6500.99
179_N183_Y1.6280.99
105_G166_A1.6030.99
121_G132_Y1.5830.99
194_Y198_K1.5730.99
29_E84_K1.5550.99
4_L12_T1.5400.98
194_Y199_G1.5290.98
18_K21_S1.5180.98
175_D178_S1.5160.98
168_E171_L1.4870.98
3_L8_L1.4680.98
186_P190_E1.4600.98
3_L19_P1.4410.98
49_V90_I1.4350.98
186_P191_T1.4250.97
112_E116_K1.4170.97
58_G61_P1.4100.97
191_T195_I1.4100.97
28_F115_E1.4060.97
74_G78_G1.3940.97
37_P103_Y1.3910.97
174_Y177_K1.3800.97
168_E172_G1.3780.97
13_G18_K1.3710.97
17_A21_S1.3620.97
31_Y135_T1.3570.97
91_Y106_K1.3560.97
28_F114_I1.3500.96
61_P67_G1.3470.96
173_P176_G1.3380.96
109_L114_I1.3280.96
59_I62_G1.3270.96
36_A42_V1.3190.96
169_V172_G1.3170.96
195_I199_G1.2690.95
191_T198_K1.2600.95
195_I198_K1.2590.95
187_Y192_K1.2520.95
22_K25_D1.2480.95
16_S21_S1.2450.94
137_V151_R1.2410.94
57_D61_P1.2350.94
74_G77_S1.2290.94
187_Y190_E1.2260.94
15_Q18_K1.2190.94
95_Q100_K1.2140.94
26_P119_K1.2060.93
8_L17_A1.2010.93
6_L12_T1.2000.93
141_A160_E1.1910.93
141_A149_W1.1810.93
171_L175_D1.1650.92
42_V99_E1.1580.92
35_S70_G1.1460.92
180_G183_Y1.1450.92
95_Q99_E1.1410.91
63_G75_G1.1350.91
112_E115_E1.1330.91
118_F121_G1.1300.91
178_S184_R1.1220.91
86_L114_I1.1090.90
186_P189_E1.1020.90
15_Q19_P1.1000.90
63_G66_A1.0890.89
4_L19_P1.0810.89
4_L17_A1.0810.89
147_V160_E1.0770.89
92_V140_L1.0690.88
45_E93_R1.0690.88
16_S20_K1.0660.88
193_E196_K1.0620.88
59_I67_G1.0620.88
160_E166_A1.0590.88
9_L146_V1.0230.86
30_W136_I1.0180.86
12_T19_P1.0170.86
178_S183_Y1.0150.86
95_Q102_F1.0020.85
44_V47_G0.9930.85
115_E119_K0.9930.85
178_S185_E0.9880.84
70_G77_S0.9860.84
60_P65_S0.9700.83
149_W160_E0.9700.83
184_R187_Y0.9680.83
91_Y104_E0.9500.82
3_L12_T0.9340.81
155_C162_G0.9340.81
181_E184_R0.9290.80
193_E197_K0.9270.80
4_L13_G0.9240.80
62_G72_R0.9190.80
177_K182_Y0.9170.79
30_W118_F0.9150.79
3_L10_L0.9120.79
30_W142_P0.9090.79
3_L7_L0.8990.78
34_F74_G0.8970.78
37_P139_G0.8960.78
124_D128_G0.8940.78
179_N184_R0.8920.78
157_K164_G0.8910.77
180_G184_R0.8880.77
163_R166_A0.8840.77
59_I90_I0.8830.77
52_I88_D0.8830.77
73_G76_G0.8810.77
123_Y127_G0.8790.76
59_I74_G0.8780.76
174_Y179_N0.8770.76
96_S99_E0.8710.76
141_A145_V0.8700.76
56_L59_I0.8690.76
63_G67_G0.8690.76
9_L18_K0.8650.75
54_G108_D0.8650.75
81_N84_K0.8650.75
13_G19_P0.8630.75
155_C159_I0.8620.75
136_I139_G0.8610.75
50_I88_D0.8590.75
160_E164_G0.8580.75
4_L20_K0.8470.74
7_L16_S0.8360.73
67_G74_G0.8310.72
17_A20_K0.8310.72
42_V102_F0.8300.72
18_K22_K0.8280.72
86_L150_L0.8280.72
60_P75_G0.8230.72
168_E188_S0.8220.72
49_V85_P0.8210.71
49_V54_G0.8180.71
9_L19_P0.8160.71
124_D127_G0.8160.71
176_G180_G0.8150.71
94_W140_L0.8110.71
16_S22_K0.8110.71
169_V188_S0.8040.70
69_W74_G0.8020.70
58_G76_G0.8020.70
44_V51_D0.7860.68
57_D63_G0.7860.68
8_L16_S0.7850.68
114_I117_M0.7810.68
65_S140_L0.7800.68
17_A22_K0.7800.68
72_R76_G0.7720.67
182_Y186_P0.7680.66
10_L20_K0.7590.65
181_E185_E0.7570.65
88_D91_Y0.7530.65
150_L159_I0.7510.65
184_R188_S0.7470.64
33_G135_T0.7400.63
10_L17_A0.7360.63
166_A172_G0.7290.62
27_Y36_A0.7220.62
41_P97_Y0.7190.61
31_Y75_G0.7180.61
20_K23_K0.7140.61
4_L10_L0.7130.61
182_Y188_S0.7090.60
51_D55_K0.7070.60
17_A23_K0.6970.59
87_P144_G0.6960.59
13_G16_S0.6900.58
169_V189_E0.6820.57
6_L16_S0.6820.57
3_L16_S0.6770.57
122_Y136_I0.6750.56
75_G179_N0.6720.56
142_P161_V0.6720.56
5_L9_L0.6700.56
187_Y191_T0.6640.55
16_S23_K0.6630.55
50_I91_Y0.6610.55
10_L15_Q0.6600.55
166_A171_L0.6600.55
10_L90_I0.6590.55
168_E192_K0.6590.55
191_T199_G0.6590.55
172_G176_G0.6580.54
45_E95_Q0.6550.54
65_S79_G0.6540.54
14_C18_K0.6530.54
29_E82_K0.6520.54
160_E163_R0.6510.54
166_A169_V0.6500.54
146_V166_A0.6480.53
189_E195_I0.6470.53
166_A200_I0.6430.53
141_A163_R0.6420.53
19_P25_D0.6360.52
191_T194_Y0.6350.52
114_I150_L0.6290.51
62_G65_S0.6260.51
5_L10_L0.6250.51
69_W75_G0.6240.51
146_V164_G0.6210.50
4_L7_L0.6160.50
122_Y127_G0.6110.49
64_G68_G0.6100.49
6_L18_K0.6060.49
79_G84_K0.6040.48
178_S186_P0.6020.48
122_Y132_Y0.6020.48
170_P176_G0.6000.48
124_D151_R0.5990.48
177_K180_G0.5990.48
112_E118_F0.5940.47
59_I65_S0.5860.46
169_V175_D0.5850.46
86_L143_G0.5850.46
177_K183_Y0.5840.46
143_G160_E0.5840.46
21_S25_D0.5830.46
112_E121_G0.5830.46
185_E189_E0.5830.46
155_C158_P0.5830.46
98_V195_I0.5820.46
57_D62_G0.5790.46
119_K123_Y0.5790.46
136_I148_V0.5740.45
60_P76_G0.5720.45
170_P186_P0.5670.44
182_Y185_E0.5650.44
32_L84_K0.5630.44
183_Y188_S0.5610.44
105_G140_L0.5590.43
114_I118_F0.5570.43
123_Y133_Y0.5560.43
127_G130_K0.5550.43
93_R102_F0.5540.43
35_S90_I0.5540.43
5_L8_L0.5530.43
139_G163_R0.5530.43
89_R167_E0.5510.42
9_L21_S0.5470.42
94_W142_P0.5450.42
65_S75_G0.5440.42
7_L17_A0.5410.41
126_R148_V0.5410.41
98_V150_L0.5390.41
195_I202_Y0.5390.41
100_K140_L0.5380.41
95_Q176_G0.5350.41
58_G62_G0.5350.41
192_K198_K0.5310.40
123_Y130_K0.5300.40
175_D183_Y0.5280.40
42_V105_G0.5280.40
172_G175_D0.5240.39
30_W140_L0.5230.39
113_K117_M0.5220.39
101_K140_L0.5200.39
198_K203_G0.5200.39
46_T55_K0.5200.39
5_L20_K0.5200.39
49_V138_V0.5160.39
12_T29_E0.5150.39
60_P63_G0.5080.38
200_I203_G0.5070.38
45_E110_P0.5060.38
98_V199_G0.5050.37
8_L20_K0.5040.37
6_L137_V0.5040.37
182_Y192_K0.5040.37
113_K116_K0.5040.37
187_Y200_I0.5030.37
117_M138_V0.5010.37
36_A68_G0.5000.37
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3zbiC 1 0.1379 39.8 0.931 Contact Map
3f42A 4 0.4433 26 0.937 Contact Map
4jg9A 2 0.5616 11.5 0.947 Contact Map
4kkfA 1 0.1626 8.6 0.95 Contact Map
2vzsA 1 0.7537 5.8 0.954 Contact Map
4n91A 2 0.7143 5.2 0.954 Contact Map
1j8bA 2 0.4138 4 0.957 Contact Map
4pfbA 1 0.7635 3.8 0.957 Contact Map
1xrxA 3 0.1084 3.6 0.958 Contact Map
4ng7A 1 0.6995 3.6 0.958 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0073 seconds.