GREMLIN Database
DUF2929 - Protein of unknown function (DUF2929)
PFAM: PF11151 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 56 (55)
Sequences: 547 (439)
Seq/√Len: 59.2
META: 0.314

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
18_G34_G3.3071.00
13_L16_M2.9721.00
15_Q29_F2.5961.00
4_I8_F2.2561.00
29_F35_A1.8651.00
11_F35_A1.8481.00
42_T46_F1.8090.99
7_F38_S1.7940.99
12_L16_M1.7140.99
1_M13_L1.6170.99
5_V8_F1.6060.99
46_F50_A1.6010.99
17_L21_V1.5800.99
19_Y24_L1.4760.98
15_Q35_A1.4660.98
26_G37_L1.4530.98
15_Q24_L1.3970.97
30_D33_T1.3600.96
11_F36_I1.3160.96
14_G38_S1.3030.95
11_F39_V1.2470.94
18_G24_L1.2160.93
23_S26_G1.0630.87
6_T10_S1.0580.87
14_G41_F1.0550.87
3_Y32_T1.0030.84
16_M20_V0.9950.84
44_L48_I0.9560.81
15_Q31_F0.9540.81
19_Y49_G0.9480.81
5_V24_L0.9270.79
10_S38_S0.9170.78
39_V42_T0.8950.77
33_T36_I0.8920.76
10_S21_V0.8530.73
49_G52_I0.8510.73
19_Y23_S0.8380.72
35_A38_S0.8270.71
21_V25_T0.8100.69
2_R24_L0.8100.69
2_R7_F0.8080.69
7_F47_I0.8010.68
7_F42_T0.7880.67
3_Y6_T0.7640.65
43_V50_A0.7630.65
48_I51_I0.7550.64
50_A53_P0.7420.62
1_M23_S0.7400.62
20_V52_I0.7380.62
32_T40_V0.7360.62
38_S54_N0.7230.60
5_V37_L0.7220.60
35_A47_I0.7110.59
20_V41_F0.6880.57
44_L52_I0.6620.54
16_M24_L0.6570.53
34_G38_S0.6540.53
43_V51_I0.6380.51
47_I52_I0.6310.50
10_S40_V0.6260.50
26_G33_T0.6220.49
36_I41_F0.6210.49
14_G42_T0.6080.48
7_F39_V0.6030.47
2_R18_G0.5880.46
19_Y27_G0.5760.44
47_I51_I0.5750.44
18_G21_V0.5690.43
5_V12_L0.5630.43
18_G29_F0.5610.43
10_S36_I0.5500.41
22_S31_F0.5490.41
45_V53_P0.5480.41
41_F44_L0.5480.41
32_T36_I0.5420.41
21_V42_T0.5240.39
4_I39_V0.5210.38
27_G39_V0.5130.37
37_L40_V0.5120.37
16_M22_S0.5100.37
21_V41_F0.5030.36
22_S27_G0.5000.36
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4pypA 1 1 8 0.852 Contact Map
3wdoA 1 1 7.6 0.853 Contact Map
1pw4A 1 1 6.3 0.859 Contact Map
4ldsA 2 1 6.1 0.859 Contact Map
2gfpA 2 1 5.3 0.863 Contact Map
4j05A 3 0.875 4.6 0.867 Contact Map
4gc0A 1 1 4.4 0.868 Contact Map
3iyzA 3 0.9821 4 0.871 Contact Map
4w251 1 0.7679 3.8 0.873 Contact Map
2zz9A 3 0.9821 3.5 0.874 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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