GREMLIN Database
DUF2924 - Protein of unknown function (DUF2924)
PFAM: PF11149 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 134 (132)
Sequences: 9601 (6276)
Seq/√Len: 546.3
META: 0.968

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
31_R35_R3.8311.00
118_R124_R3.1841.00
84_R95_R3.0711.00
11_L15_R2.9201.00
10_S13_E2.8801.00
17_R20_E2.8791.00
92_R106_N2.6571.00
94_H120_I2.5601.00
2_E17_R2.4061.00
41_R44_E2.3911.00
97_T104_E2.2511.00
99_L104_E2.2461.00
103_F116_I2.1931.00
108_R119_A2.1571.00
94_H105_Y2.1251.00
51_S54_T2.0311.00
19_R25_P2.0191.00
88_E93_T1.9251.00
40_Y44_E1.9001.00
44_E49_G1.8461.00
99_L109_T1.7541.00
104_E107_G1.6671.00
84_R97_T1.5961.00
3_I39_A1.5231.00
86_V93_T1.5071.00
99_L102_G1.5051.00
2_E5_A1.4881.00
110_Y119_A1.4881.00
115_A119_A1.4551.00
98_V103_F1.4481.00
65_A68_R1.4361.00
105_Y119_A1.4291.00
57_R60_R1.4221.00
111_R115_A1.4171.00
104_E109_T1.3981.00
7_R35_R1.3841.00
41_R45_L1.3801.00
85_L98_V1.3631.00
105_Y116_I1.3141.00
17_R21_L1.2981.00
5_A17_R1.2951.00
9_L13_E1.2711.00
101_D109_T1.2511.00
22_F41_R1.2501.00
96_V131_F1.2231.00
32_D36_R1.2081.00
29_L33_L1.2021.00
118_R121_T1.2011.00
79_L98_V1.1701.00
114_S117_A1.1631.00
116_I119_A1.1411.00
13_E16_A1.1371.00
21_L45_L1.1301.00
66_A69_G1.1291.00
38_L42_L1.1271.00
50_L54_T1.1221.00
18_W38_L1.1181.00
22_F38_L1.1131.00
86_V95_R1.0921.00
52_P56_R1.0761.00
68_R71_R1.0741.00
88_E91_G1.0561.00
121_T125_W1.0511.00
57_R61_L1.0341.00
58_L62_A1.0321.00
6_L35_R1.0281.00
16_A20_E1.0151.00
115_A124_R1.0071.00
42_L46_A1.0041.00
79_L85_L1.0011.00
65_A69_G0.9921.00
6_L42_L0.9921.00
9_L17_R0.9721.00
21_L38_L0.9711.00
114_S124_R0.9361.00
52_P55_R0.9271.00
125_W129_R0.9211.00
123_T129_R0.9061.00
32_D35_R0.9021.00
116_I131_F0.8831.00
22_F37_R0.8831.00
125_W132_G0.8771.00
115_A128_P0.8761.00
40_Y50_L0.8691.00
128_P132_G0.8691.00
39_A42_L0.8531.00
67_A70_A0.8411.00
66_A70_A0.8401.00
94_H106_N0.8331.00
26_P34_L0.8181.00
4_A7_R0.8111.00
21_L41_R0.8091.00
54_T57_R0.8051.00
29_L37_R0.8011.00
79_L103_F0.8011.00
128_P133_L0.8001.00
89_W94_H0.7771.00
96_V103_F0.7701.00
55_R59_D0.7691.00
56_R60_R0.7671.00
65_A70_A0.7601.00
6_L39_A0.7461.00
69_G72_A0.7401.00
15_R29_L0.7341.00
81_P100_E0.7311.00
89_W121_T0.7311.00
66_A73_R0.7301.00
12_A16_A0.7291.00
67_A71_R0.7281.00
34_L37_R0.7271.00
56_R59_D0.7271.00
68_R73_R0.7211.00
33_L37_R0.7161.00
74_R78_R0.7141.00
66_A71_R0.7081.00
30_S35_R0.7071.00
65_A71_R0.7061.00
44_E47_Y0.6991.00
66_A72_A0.6961.00
15_R26_P0.6941.00
30_S33_L0.6921.00
18_W24_R0.6921.00
84_R89_W0.6871.00
11_L31_R0.6821.00
60_R64_D0.6761.00
114_S118_R0.6721.00
69_G73_R0.6711.00
39_A43_Q0.6701.00
19_R26_P0.6661.00
72_A76_R0.6631.00
65_A72_A0.6611.00
3_I35_R0.6601.00
86_V97_T0.6581.00
43_Q48_G0.6561.00
6_L14_L0.6541.00
68_R74_R0.6521.00
67_A72_A0.6511.00
21_L42_L0.6301.00
124_R129_R0.6281.00
11_L28_P0.6261.00
38_L41_R0.6261.00
110_Y116_I0.6201.00
18_W27_P0.6191.00
5_A9_L0.6101.00
77_R80_K0.6051.00
3_I7_R0.6011.00
50_L58_L0.6011.00
116_I120_I0.6001.00
69_G75_P0.5961.00
10_S31_R0.5961.00
35_R38_L0.5961.00
30_S129_R0.5891.00
75_P78_R0.5891.00
67_A75_P0.5861.00
3_I9_L0.5810.99
15_R19_R0.5810.99
18_W33_L0.5810.99
5_A8_D0.5760.99
96_V120_I0.5750.99
71_R75_P0.5730.99
19_R23_G0.5720.99
61_L64_D0.5700.99
27_P33_L0.5680.99
5_A13_E0.5660.99
51_S55_R0.5550.99
70_A77_R0.5500.99
118_R129_R0.5490.99
60_R110_Y0.5470.99
4_A8_D0.5430.99
65_A73_R0.5420.99
29_L126_N0.5400.99
54_T60_R0.5390.99
71_R74_R0.5360.99
114_S129_R0.5290.99
6_L38_L0.5280.99
67_A74_R0.5260.99
64_D69_G0.5260.99
105_Y115_A0.5240.99
71_R76_R0.5240.99
73_R76_R0.5240.99
35_R42_L0.5210.99
115_A118_R0.5210.99
89_W92_R0.5200.99
102_G109_T0.5190.99
24_R27_P0.5190.99
68_R72_A0.5190.99
20_E23_G0.5170.99
89_W125_W0.5160.99
30_S37_R0.5120.99
125_W128_P0.5100.99
72_A75_P0.5090.99
73_R77_R0.5070.99
26_P29_L0.5070.99
96_V116_I0.5070.99
18_W21_L0.5040.99
48_G54_T0.5030.99
70_A76_R0.5000.98
94_H116_I0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3gwbA 2 0.8433 15.9 0.934 Contact Map
3hdiA 2 0.8731 14.9 0.935 Contact Map
1t3wA 4 0.5075 13.3 0.936 Contact Map
3plxA 3 0.1866 12.7 0.937 Contact Map
1grjA 1 0.9104 12.6 0.937 Contact Map
3c9pA 1 0.6119 12.2 0.937 Contact Map
2f23A 1 0.9254 9 0.941 Contact Map
1uheB 2 0.1791 8.5 0.942 Contact Map
1vc3A 1 0.1791 8.5 0.942 Contact Map
3bg3A 4 0.8433 7.8 0.943 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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