GREMLIN Database
DUF2922 - Protein of unknown function (DUF2922)
PFAM: PF11148 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 67 (67)
Sequences: 3033 (2316)
Seq/√Len: 282.9
META: 0.675

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
36_D54_K2.4011.00
8_K53_S2.3711.00
27_T30_E2.3081.00
35_M54_K2.2371.00
8_K55_K2.1141.00
4_E16_T2.0711.00
42_N50_D1.9421.00
28_A32_K1.8271.00
6_T56_S1.8231.00
37_T41_K1.8141.00
61_E65_T1.7751.00
46_T49_G1.7361.00
36_D40_A1.7291.00
32_K54_K1.6401.00
4_E58_R1.6391.00
23_K30_E1.6111.00
10_E50_D1.5351.00
39_I54_K1.5251.00
2_T62_T1.5061.00
14_T55_K1.4921.00
6_T14_T1.4761.00
58_R64_V1.4441.00
9_T48_G1.3251.00
5_L35_M1.3111.00
34_A38_I1.2631.00
15_V51_L1.2591.00
9_T15_V1.2461.00
2_T18_S1.2301.00
6_T16_T1.1951.00
8_K14_T1.1471.00
4_E18_S1.1441.00
4_E60_V1.1131.00
8_K12_G1.1081.00
29_A33_A1.0911.00
32_K36_D1.0901.00
1_K24_E1.0201.00
31_V67_L1.0161.00
39_I51_L1.0041.00
56_S66_E0.9671.00
2_T20_P0.9411.00
37_T40_A0.9171.00
9_T49_G0.8951.00
11_E48_G0.8881.00
44_F51_L0.8821.00
17_I38_I0.8821.00
13_K48_G0.8731.00
23_K27_T0.8641.00
22_P34_A0.8361.00
9_T46_T0.7980.99
31_V57_A0.7880.99
22_P26_L0.7820.99
13_K47_S0.7750.99
33_A37_T0.7720.99
7_F35_M0.7680.99
22_P59_I0.7570.99
34_A37_T0.7550.99
45_T50_D0.7530.99
10_E52_V0.7380.99
23_K26_L0.7370.99
15_V20_P0.6960.98
1_K61_E0.6930.98
39_I53_S0.6810.98
26_L59_I0.6800.98
60_V64_V0.6800.98
46_T50_D0.6710.98
10_E49_G0.6680.98
35_M57_A0.6590.98
11_E49_G0.6490.97
35_M39_I0.6450.97
5_L19_I0.6430.97
46_T51_L0.6320.97
5_L54_K0.6170.97
58_R66_E0.6050.96
28_A67_L0.5950.96
1_K22_P0.5920.96
6_T58_R0.5920.96
26_L31_V0.5910.96
3_L22_P0.5860.95
10_E48_G0.5820.95
18_S60_V0.5770.95
12_G34_A0.5740.95
9_T17_I0.5680.95
19_I41_K0.5530.94
28_A31_V0.5530.94
38_I41_K0.5510.94
58_R62_T0.5480.94
24_E34_A0.5470.93
30_E33_A0.5460.93
26_L34_A0.5460.93
18_S22_P0.5460.93
30_E34_A0.5380.93
11_E47_S0.5370.93
19_I61_E0.5250.92
32_K67_L0.5240.92
39_I52_V0.5210.92
6_T55_K0.5210.92
9_T51_L0.5180.92
45_T49_G0.5050.90
4_E44_F0.5010.90
42_N51_L0.5000.90
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1b7yB 2 0.6716 19.5 0.816 Contact Map
2rhqB 2 0.7015 18 0.82 Contact Map
3pcoB 2 0.7761 15.5 0.824 Contact Map
4p72A 2 0.7612 12.9 0.831 Contact Map
3cmqA 1 0.7761 10.8 0.836 Contact Map
1ksiA 2 0.6866 9.9 0.839 Contact Map
3loyA 2 0.6567 9.9 0.84 Contact Map
3a0oA 1 0.3134 8.9 0.843 Contact Map
1hn0A 1 0.3433 7.3 0.849 Contact Map
4dezA 2 0 6.7 0.851 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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