GREMLIN Database
DUF2905 - Protein of unknown function (DUF2905)
PFAM: PF11146 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 62 (62)
Sequences: 22816 (13994)
Seq/√Len: 1777.2
META: 0.959

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
35_E40_T3.5151.00
33_R40_T2.6991.00
5_I12_V2.4271.00
5_I19_P2.1021.00
1_G19_P2.0671.00
36_R39_F1.9691.00
56_T60_W1.8661.00
3_L7_L1.8591.00
9_L12_V1.7281.00
31_D47_T1.7211.00
30_G46_V1.6131.00
33_R42_Y1.5581.00
57_L60_W1.4921.00
6_V10_V1.4211.00
52_S56_T1.3801.00
7_L11_L1.3421.00
27_R33_R1.2981.00
34_I39_F1.2831.00
4_L18_L1.2711.00
49_I53_V1.2431.00
19_P23_R1.1701.00
9_L13_V1.1691.00
26_G47_T1.1421.00
10_V14_V1.1361.00
16_L20_L1.1121.00
4_L11_L1.1121.00
53_V57_L1.0931.00
48_S52_S1.0801.00
42_Y46_V1.0711.00
19_P22_G1.0431.00
5_I16_L1.0321.00
1_G18_L1.0081.00
17_L21_G0.9991.00
16_L19_P0.9651.00
5_I15_G0.9611.00
55_L59_L0.9601.00
9_L16_L0.9521.00
8_G12_V0.9271.00
33_R36_R0.9261.00
48_S60_W0.9071.00
43_F46_V0.9051.00
28_L31_D0.8871.00
6_V9_L0.8841.00
56_T59_L0.8791.00
58_L62_F0.8681.00
46_V50_L0.8631.00
57_L61_L0.8621.00
13_V16_L0.8571.00
3_L6_V0.8511.00
32_I45_L0.8361.00
53_V60_W0.8241.00
20_L23_R0.8191.00
31_D46_V0.8101.00
13_V17_L0.8031.00
34_I37_G0.7831.00
12_V19_P0.7821.00
54_V58_L0.7601.00
48_S56_T0.7521.00
34_I41_F0.7461.00
21_G24_P0.7331.00
24_P27_R0.7301.00
4_L14_V0.7191.00
3_L19_P0.7181.00
28_L46_V0.7021.00
33_R37_G0.7011.00
45_L49_I0.6841.00
18_L22_G0.6761.00
43_F48_S0.6731.00
25_L51_L0.6701.00
2_K19_P0.6431.00
18_L23_R0.6291.00
4_L7_L0.6271.00
39_F42_Y0.6261.00
7_L10_V0.6141.00
4_L12_V0.6001.00
50_L54_V0.5941.00
3_L10_V0.5931.00
5_I9_L0.5931.00
37_G40_T0.5911.00
26_G31_D0.5871.00
31_D42_Y0.5821.00
36_R41_F0.5631.00
10_V13_V0.5561.00
17_L23_R0.5411.00
6_V13_V0.5411.00
25_L47_T0.5291.00
45_L48_S0.5281.00
14_V18_L0.5221.00
2_K8_G0.5201.00
4_L9_L0.5131.00
42_Y47_T0.5091.00
35_E39_F0.5031.00
2_K23_R0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ev6A 3 0.8871 9 0.84 Contact Map
4i0uA 4 0.8871 7.3 0.847 Contact Map
1zoyC 1 0.9839 6.1 0.852 Contact Map
4ysxC 1 0.9839 4.6 0.86 Contact Map
4ytpC 1 0.9839 4.2 0.863 Contact Map
3j9pD 4 1 2.9 0.874 Contact Map
2wdqC 1 0.9355 2.5 0.878 Contact Map
4bbjA 1 0.9032 2.5 0.878 Contact Map
2m59A 2 0.4355 2.4 0.879 Contact Map
2h88C 2 0.9194 2.3 0.88 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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