GREMLIN Database
DUF2919 - Protein of unknown function (DUF2919)
PFAM: PF11143 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 146 (145)
Sequences: 709 (521)
Seq/√Len: 43.3
META: 0.597

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
1_Y142_D4.6731.00
29_W60_L3.4361.00
69_L90_G3.1031.00
28_T63_G2.9841.00
90_G144_F2.6001.00
26_A29_W2.5361.00
28_T59_G2.4461.00
2_S5_D2.4391.00
139_R143_C2.4211.00
29_W63_G2.3301.00
45_L48_L2.2921.00
72_L76_R2.2341.00
71_L76_R2.0910.99
21_V130_A2.0870.99
98_A131_L2.0770.99
116_F121_A2.0510.99
38_S41_Q2.0380.99
7_D11_C2.0340.99
66_A94_L1.9750.99
1_Y12_L1.8940.99
5_D139_R1.8810.99
35_A41_Q1.8060.98
71_L74_G1.8030.98
39_R46_L1.7710.98
25_L98_A1.7570.98
45_L49_F1.7550.98
38_S42_G1.7420.98
75_R87_W1.7090.98
88_R126_L1.6140.97
118_W121_A1.5810.96
6_Y12_L1.5810.96
89_H92_W1.5620.96
12_L142_D1.5480.96
24_F127_D1.5250.95
13_K24_F1.5190.95
90_G98_A1.5120.95
69_L93_L1.5090.95
95_L135_L1.4970.95
93_L106_L1.4950.95
42_G46_L1.4670.94
130_A137_S1.4600.94
101_D104_L1.4460.94
139_R144_F1.3650.92
86_L90_G1.3440.91
41_Q44_D1.3360.91
90_G93_L1.2500.87
66_A97_A1.2380.87
18_L140_L1.2350.87
26_A32_F1.2150.86
96_L99_L1.1810.84
59_G63_G1.1700.84
138_R141_R1.1310.82
39_R42_G1.1310.82
98_A130_A1.1220.81
87_W90_G1.1160.81
133_Y140_L1.1040.80
129_W132_L1.0780.78
99_L103_A1.0770.78
23_L70_L1.0770.78
78_R81_K1.0740.78
2_S6_Y1.0570.77
18_L60_L1.0540.77
57_Y124_L1.0410.76
35_A38_S1.0400.76
32_F36_G1.0380.76
94_L134_L1.0240.75
96_L100_L1.0210.74
41_Q49_F1.0090.74
15_P143_C0.9880.72
77_P84_R0.9880.72
117_S122_L0.9860.72
35_A42_G0.9850.72
3_P139_R0.9790.71
87_W94_L0.9780.71
60_L63_G0.9730.71
65_P68_L0.9720.71
7_D28_T0.9610.70
24_F126_L0.9480.69
128_L141_R0.9450.69
125_L129_W0.9340.68
73_S76_R0.9330.68
99_L128_L0.9320.67
36_G42_G0.9180.66
69_L134_L0.9090.65
109_L113_H0.9070.65
38_S46_L0.9050.65
14_P131_L0.8950.64
10_G46_L0.8830.63
47_A72_L0.8790.63
21_V25_L0.8760.63
70_L131_L0.8680.62
96_L125_L0.8640.61
41_Q46_L0.8530.60
21_V40_Q0.8520.60
85_R88_R0.8490.60
92_W96_L0.8480.60
27_R63_G0.8470.60
14_P143_C0.8460.60
63_G101_D0.8440.60
6_Y13_K0.8390.59
75_R78_R0.8360.59
51_P57_Y0.8360.59
61_L86_L0.8220.58
66_A141_R0.8130.57
17_L133_Y0.8010.56
51_P127_D0.8010.56
23_L61_L0.7970.55
10_G29_W0.7860.54
66_A103_A0.7800.54
89_H93_L0.7750.53
7_D91_R0.7730.53
50_Y59_G0.7700.53
29_W41_Q0.7680.53
103_A138_R0.7670.52
113_H121_A0.7650.52
104_L132_L0.7640.52
107_Y137_S0.7620.52
22_L94_L0.7580.52
34_M145_A0.7530.51
48_L51_P0.7510.51
137_S140_L0.7330.49
122_L126_L0.7290.49
67_L106_L0.7290.49
38_S63_G0.7250.48
68_L102_L0.7240.48
24_F27_R0.7140.47
12_L143_C0.7100.47
28_T50_Y0.7060.47
95_L122_L0.7050.47
110_W114_G0.7040.46
1_Y4_E0.7010.46
15_P18_L0.6990.46
19_W101_D0.6890.45
7_D19_W0.6860.45
89_H96_L0.6860.45
61_L103_A0.6850.45
116_F129_W0.6790.44
23_L66_A0.6780.44
29_W133_Y0.6710.43
123_Q127_D0.6710.43
68_L92_W0.6700.43
29_W38_S0.6700.43
114_G121_A0.6680.43
99_L106_L0.6680.43
86_L140_L0.6510.41
37_A50_Y0.6500.41
45_L128_L0.6430.41
93_L100_L0.6350.40
87_W144_F0.6290.39
45_L52_D0.6280.39
69_L144_F0.6220.39
3_P24_F0.6210.39
71_L118_W0.6200.39
15_P140_L0.6170.38
71_L103_A0.6110.38
46_L50_Y0.6090.38
17_L26_A0.6090.38
104_L121_A0.6040.37
44_D47_A0.6040.37
31_L118_W0.6030.37
15_P127_D0.6000.37
3_P83_V0.5980.37
35_A123_Q0.5930.36
43_S102_L0.5910.36
19_W26_A0.5890.36
14_P30_L0.5870.36
35_A50_Y0.5860.36
30_L87_W0.5840.35
105_Q112_Q0.5830.35
40_Q43_S0.5820.35
19_W36_G0.5800.35
96_L124_L0.5780.35
116_F120_L0.5750.35
86_L89_H0.5710.34
25_L78_R0.5700.34
105_Q109_L0.5690.34
86_L122_L0.5680.34
48_L109_L0.5630.34
1_Y6_Y0.5620.34
22_L80_S0.5610.33
22_L75_R0.5560.33
22_L73_S0.5540.33
96_L110_W0.5530.33
7_D108_H0.5510.33
70_L78_R0.5510.33
61_L64_L0.5500.33
6_Y48_L0.5500.33
118_W122_L0.5490.32
33_V115_Q0.5460.32
36_G41_Q0.5460.32
47_A83_V0.5460.32
50_Y63_G0.5450.32
113_H117_S0.5420.32
24_F30_L0.5410.32
60_L133_Y0.5390.32
95_L102_L0.5360.31
23_L58_L0.5300.31
95_L136_R0.5300.31
45_L50_Y0.5260.31
21_V94_L0.5260.31
60_L82_W0.5250.30
69_L97_A0.5230.30
45_L56_F0.5210.30
73_S140_L0.5200.30
104_L133_Y0.5190.30
103_A107_Y0.5170.30
131_L140_L0.5140.30
51_P56_F0.5130.30
67_L117_S0.5120.29
34_M47_A0.5120.29
28_T35_A0.5100.29
109_L119_L0.5070.29
81_K107_Y0.5070.29
28_T56_F0.5070.29
20_L134_L0.5050.29
14_P42_G0.5030.29
85_R141_R0.5020.29
27_R53_K0.5000.28
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4qncA 2 0.4932 3.6 0.945 Contact Map
2a65A 2 0.5753 2.3 0.95 Contact Map
2d8rA 1 0.226 1.7 0.954 Contact Map
4k5yA 1 0.9041 1.6 0.955 Contact Map
4oo9A 1 0.6986 1.5 0.955 Contact Map
2hqvA 2 0.2877 1.4 0.956 Contact Map
1nxmA 2 0.3082 1.2 0.958 Contact Map
4qndA 2 0.5959 1.2 0.958 Contact Map
4l6rA 1 0.9658 1.1 0.959 Contact Map
3lm8A 2 0.2877 1.1 0.959 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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