GREMLIN Database
DUF2914 - Protein of unknown function (DUF2914)
PFAM: PF11141 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 63 (62)
Sequences: 9338 (6138)
Seq/√Len: 779.6
META: 0.963

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
9_Y47_E2.7841.00
5_Y17_R2.6761.00
20_L30_T2.5821.00
7_R49_E2.3461.00
50_T54_Q2.1941.00
9_Y45_R2.1741.00
7_R14_E2.1481.00
6_H32_S2.0841.00
47_E55_V1.9971.00
9_Y14_E1.9961.00
14_E17_R1.8331.00
3_T19_P1.8261.00
45_R58_R1.6521.00
11_D43_D1.6011.00
37_L40_W1.5981.00
43_D62_T1.5581.00
7_R17_R1.5501.00
25_G28_W1.5271.00
10_Y40_W1.4951.00
55_V58_R1.4921.00
7_R47_E1.4691.00
47_E58_R1.4651.00
6_H20_L1.3811.00
15_V40_W1.3491.00
5_Y19_P1.3361.00
49_E55_V1.0671.00
49_E53_G1.0531.00
5_Y49_E1.0471.00
16_A34_K1.0451.00
24_R28_W1.0321.00
10_Y15_V1.0261.00
3_T21_P1.0121.00
6_H48_V1.0091.00
15_V34_K0.9851.00
43_D60_R0.9751.00
4_I56_L0.8991.00
3_T51_E0.8881.00
18_V34_K0.8461.00
15_V44_W0.8371.00
18_V32_S0.8161.00
48_V57_G0.8121.00
16_A33_S0.8071.00
34_K37_L0.7661.00
21_P24_R0.7501.00
10_Y13_K0.7491.00
5_Y51_E0.7421.00
10_Y44_W0.7381.00
44_W61_F0.7291.00
50_T56_L0.7171.00
17_R49_E0.7011.00
12_G45_R0.7001.00
23_V28_W0.6731.00
28_W31_Y0.6711.00
10_Y42_G0.6651.00
38_P41_P0.6601.00
23_V33_S0.6541.00
20_L32_S0.6501.00
6_H30_T0.6311.00
45_R60_R0.6301.00
57_G60_R0.6201.00
36_L40_W0.6191.00
2_T51_E0.6041.00
54_Q57_G0.6031.00
24_R27_G0.5951.00
4_I28_W0.5951.00
22_I30_T0.5931.00
23_V26_P0.5921.00
8_W32_S0.5901.00
34_K40_W0.5901.00
42_G61_F0.5881.00
48_V59_V0.5681.00
33_S36_L0.5671.00
13_K27_G0.5661.00
2_T52_D0.5631.00
22_I28_W0.5601.00
9_Y49_E0.5571.00
36_L63_V0.5531.00
29_R34_K0.5491.00
4_I30_T0.5481.00
10_Y41_P0.5471.00
16_A19_P0.5381.00
35_T40_W0.5381.00
16_A23_V0.5371.00
23_V35_T0.5311.00
2_T22_I0.5261.00
25_G29_R0.5231.00
35_T39_G0.5181.00
44_W63_V0.5131.00
37_L41_P0.5111.00
5_Y53_G0.5041.00
46_V61_F0.5021.00
14_E49_E0.5011.00
46_V55_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1bihA 2 0.9365 66.1 0.756 Contact Map
3b43A 1 1 64.1 0.759 Contact Map
3o81A 1 1 63.9 0.759 Contact Map
3p3yA 2 1 63.1 0.761 Contact Map
4i2xE 1 0.9841 62.6 0.762 Contact Map
2e7cA 1 1 62.6 0.762 Contact Map
3v2aR 1 0 59.3 0.766 Contact Map
3jtsB 1 1 59.3 0.766 Contact Map
2eysA 1 0.9683 59 0.766 Contact Map
1lk2B 1 1 58.2 0.768 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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