GREMLIN Database
SfLAP - Sap, sulfolipid-1-addressing protein
PFAM: PF11139 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 214 (213)
Sequences: 8751 (6824)
Seq/√Len: 467.5
META: 0.869

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
26_R29_R3.5551.00
70_V74_V2.7141.00
73_L212_G2.5031.00
179_E183_E2.5011.00
46_G153_L2.4601.00
181_L184_R2.4501.00
188_W192_H2.4141.00
85_R89_R2.3991.00
192_H195_A2.3841.00
83_A202_L2.2431.00
177_R181_L2.2381.00
183_E187_D2.1281.00
73_L209_L2.1091.00
67_W71_L2.0731.00
5_A159_I2.0631.00
76_G205_G2.0621.00
116_G120_L2.0261.00
76_G209_L1.9881.00
66_T70_V1.9861.00
170_L178_A1.9811.00
47_L51_L1.9671.00
35_L165_L1.9081.00
132_Y136_L1.9061.00
169_L173_V1.8851.00
187_D191_R1.8801.00
207_L211_K1.8741.00
180_A184_R1.8541.00
7_A131_L1.7891.00
38_W161_L1.7391.00
118_G122_G1.7061.00
39_L161_L1.7031.00
84_V88_R1.7021.00
175_P178_A1.6911.00
110_S113_G1.6741.00
181_L185_L1.6681.00
33_A37_G1.6611.00
101_K105_R1.6111.00
144_L152_A1.5101.00
142_A149_Q1.5091.00
83_A198_A1.5071.00
146_T150_V1.5001.00
46_G132_Y1.4951.00
81_L85_R1.4931.00
28_R172_L1.4821.00
174_A177_R1.4811.00
145_S148_E1.4791.00
37_G115_F1.4791.00
109_A113_G1.4751.00
144_L148_E1.4741.00
46_G136_L1.4621.00
11_S14_P1.4581.00
186_R190_E1.4501.00
80_L84_V1.4451.00
24_S30_N1.4411.00
104_A107_D1.4261.00
177_R180_A1.4221.00
166_V170_L1.4201.00
47_L153_L1.4051.00
9_A162_L1.4041.00
80_L205_G1.3741.00
176_E179_E1.3611.00
117_L120_L1.3591.00
50_V149_Q1.3471.00
109_A114_A1.3291.00
195_A199_V1.3211.00
153_L157_V1.3121.00
199_V203_V1.3051.00
77_V81_L1.3041.00
105_R108_R1.2901.00
102_W107_D1.2871.00
175_P179_E1.2871.00
31_G168_L1.2831.00
117_L121_L1.2831.00
113_G116_G1.2601.00
41_G122_G1.2391.00
144_L149_Q1.2231.00
115_F119_A1.2171.00
87_W90_R1.2171.00
18_V22_L1.2011.00
119_A123_L1.1991.00
185_L189_L1.1941.00
112_G116_G1.1891.00
165_L169_L1.1841.00
32_L172_L1.1741.00
148_E151_L1.1651.00
134_A138_A1.1481.00
35_L168_L1.1471.00
49_V133_L1.1401.00
170_L181_L1.1241.00
83_A87_W1.1161.00
102_W105_R1.1051.00
100_P103_M1.0991.00
29_R32_L1.0941.00
49_V136_L1.0871.00
42_L157_V1.0841.00
8_A156_F1.0811.00
135_A156_F1.0801.00
71_L75_L1.0721.00
30_N114_A1.0661.00
38_W42_L1.0651.00
43_L47_L1.0641.00
98_K101_K1.0581.00
178_A181_L1.0511.00
139_I152_A1.0481.00
4_L135_A1.0411.00
2_L155_V1.0361.00
92_R95_E1.0341.00
152_A155_V1.0331.00
48_V52_V1.0201.00
194_R198_A1.0191.00
87_W198_A1.0091.00
8_A11_S1.0081.00
21_L24_S1.0061.00
73_L76_G1.0061.00
3_P7_A0.9951.00
187_D190_E0.9931.00
38_W122_G0.9911.00
43_L157_V0.9911.00
95_E98_K0.9881.00
73_L77_V0.9831.00
170_L174_A0.9791.00
26_R30_N0.9731.00
27_P30_N0.9671.00
86_L198_A0.9641.00
142_A152_A0.9591.00
50_V153_L0.9571.00
45_V49_V0.9511.00
122_G125_N0.9501.00
76_G80_L0.9471.00
82_L201_L0.9461.00
64_P68_V0.9441.00
40_L44_A0.9421.00
164_V167_P0.9361.00
105_R113_G0.9271.00
41_G45_V0.9261.00
206_V210_G0.9261.00
200_L204_L0.9181.00
145_S149_Q0.9161.00
174_A181_L0.9091.00
136_L140_A0.9031.00
102_W106_L0.9021.00
161_L165_L0.9001.00
110_S118_G0.8961.00
65_S68_V0.8891.00
14_P17_A0.8881.00
99_P105_R0.8821.00
120_L123_L0.8781.00
6_L10_L0.8781.00
52_V56_A0.8761.00
147_A151_L0.8741.00
83_A205_G0.8691.00
115_F118_G0.8671.00
103_M106_L0.8671.00
29_R33_A0.8631.00
156_F160_A0.8551.00
33_A111_P0.8521.00
151_L155_V0.8491.00
13_T16_A0.8481.00
132_Y156_F0.8471.00
43_L46_G0.8461.00
64_P69_A0.8391.00
98_K102_W0.8391.00
72_D211_K0.8381.00
101_K104_A0.8381.00
130_L133_L0.8331.00
91_P94_G0.8331.00
79_L83_A0.8321.00
28_R32_L0.8311.00
198_A202_L0.8261.00
91_P95_E0.8261.00
198_A201_L0.8261.00
32_L168_L0.8241.00
80_L83_A0.8241.00
47_L150_V0.8151.00
39_L157_V0.8151.00
2_L5_A0.8131.00
111_P114_A0.8121.00
42_L161_L0.8121.00
129_L133_L0.8061.00
97_A103_M0.8031.00
50_V139_I0.8021.00
166_V169_L0.8001.00
69_A72_D0.7871.00
201_L204_L0.7861.00
139_I153_L0.7841.00
96_P99_P0.7841.00
72_D137_A0.7791.00
8_A160_A0.7781.00
114_A118_G0.7781.00
119_A125_N0.7771.00
39_L158_L0.7741.00
43_L154_L0.7671.00
184_R187_D0.7651.00
6_L9_A0.7631.00
25_P29_R0.7591.00
128_P131_L0.7591.00
28_R31_G0.7581.00
107_D110_S0.7571.00
98_K104_A0.7561.00
155_V159_I0.7521.00
42_L132_Y0.7511.00
67_W70_V0.7421.00
112_G115_F0.7401.00
84_V87_W0.7371.00
21_L30_N0.7361.00
51_L146_T0.7331.00
59_S63_S0.7291.00
111_P115_F0.7291.00
13_T17_A0.7281.00
202_L210_G0.7241.00
129_L136_L0.7211.00
77_V209_L0.7201.00
157_V160_A0.7201.00
139_I149_Q0.7181.00
49_V52_V0.7131.00
118_G121_L0.7121.00
35_L164_V0.7031.00
45_V126_P0.7031.00
28_R175_P0.7021.00
203_V206_V0.7011.00
163_P167_P0.7011.00
119_A122_G0.6961.00
99_P102_W0.6941.00
109_A112_G0.6901.00
35_L39_L0.6891.00
165_L168_L0.6881.00
19_I22_L0.6881.00
85_R88_R0.6881.00
132_Y157_V0.6841.00
82_L86_L0.6821.00
83_A86_L0.6791.00
207_L210_G0.6681.00
40_L115_F0.6671.00
209_L213_I0.6641.00
4_L134_A0.6621.00
79_L201_L0.6571.00
19_I23_L0.6551.00
131_L134_A0.6551.00
68_V137_A0.6521.00
132_Y135_A0.6521.00
46_G53_L0.6491.00
188_W191_R0.6461.00
158_L165_L0.6431.00
17_A20_L0.6421.00
137_A141_A0.6391.00
135_A139_I0.6371.00
94_G102_W0.6361.00
162_L166_V0.6361.00
108_R113_G0.6300.99
69_A212_G0.6250.99
5_A9_A0.6240.99
41_G119_A0.6240.99
189_L192_H0.6230.99
94_G103_M0.6190.99
18_V164_V0.6160.99
19_I185_L0.6150.99
50_V136_L0.6130.99
197_M201_L0.6120.99
184_R188_W0.6110.99
114_A122_G0.6060.99
114_A125_N0.6040.99
171_Y175_P0.6040.99
27_P171_Y0.5990.99
103_M107_D0.5970.99
42_L46_G0.5960.99
8_A42_L0.5940.99
8_A132_Y0.5930.99
9_A12_P0.5920.99
94_G97_A0.5900.99
75_L134_A0.5870.99
136_L153_L0.5860.99
202_L205_G0.5800.99
14_P38_W0.5770.99
7_A204_L0.5770.99
74_V78_L0.5770.99
68_V72_D0.5710.99
147_A150_V0.5690.99
8_A131_L0.5660.99
45_V123_L0.5660.99
44_A47_L0.5640.99
118_G125_N0.5620.99
3_P6_L0.5620.99
44_A51_L0.5610.99
121_L125_N0.5600.99
46_G49_V0.5560.99
148_E152_A0.5530.99
109_A116_G0.5520.99
170_L177_R0.5430.98
146_T149_Q0.5420.98
94_G98_K0.5400.98
99_P104_A0.5400.98
189_L196_V0.5360.98
25_P28_R0.5340.98
20_L23_L0.5340.98
100_P104_A0.5310.98
51_L55_G0.5310.98
114_A121_L0.5300.98
84_V89_R0.5290.98
157_V161_L0.5240.98
98_K105_R0.5230.98
31_G35_L0.5230.98
106_L109_A0.5230.98
76_G212_G0.5220.98
91_P97_A0.5190.98
35_L166_V0.5170.98
193_N196_V0.5160.98
87_W202_L0.5160.98
193_N197_M0.5160.98
183_E186_R0.5140.98
81_L84_V0.5130.98
113_G118_G0.5110.98
37_G41_G0.5110.98
189_L193_N0.5100.98
90_R93_P0.5080.98
14_P18_V0.5060.98
132_Y153_L0.5030.98
23_L186_R0.5020.97
154_L158_L0.5020.97
21_L31_G0.5010.97
86_L197_M0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3wdoA 1 0.8692 28.6 0.912 Contact Map
3giaA 1 0.4252 23.8 0.915 Contact Map
4m64A 1 0.8925 21.8 0.916 Contact Map
3j1zP 8 0.4813 19.8 0.918 Contact Map
3ne5A 3 0.8738 19.1 0.919 Contact Map
2wswA 3 0.3598 16.4 0.921 Contact Map
2gfpA 2 0.8692 12.9 0.925 Contact Map
3w9iA 3 0.8972 12.6 0.925 Contact Map
4c7rA 3 0.3037 12.5 0.925 Contact Map
4pxzA 1 0.9299 12.1 0.925 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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