GREMLIN Database
DUF2911 - Protein of unknown function (DUF2911)
PFAM: PF11138 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 145 (145)
Sequences: 25276 (16032)
Seq/√Len: 1331.3
META: 0.949

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
42_T72_T3.9671.00
23_S117_T2.9101.00
51_T67_T2.8931.00
52_F56_V2.7901.00
78_E105_K2.6881.00
86_Q99_K2.5691.00
57_T62_K2.4921.00
55_D65_A2.0921.00
61_K102_L2.0751.00
28_K32_G2.0621.00
49_T67_T1.9511.00
37_G75_G1.9051.00
132_L143_V1.7671.00
55_D64_P1.7631.00
135_A140_R1.7261.00
85_K99_K1.7241.00
9_T14_D1.7171.00
80_T105_K1.7101.00
110_K138_K1.6921.00
63_L83_F1.6801.00
96_D99_K1.6801.00
123_D133_V1.6511.00
118_L134_L1.6451.00
59_G144_P1.6351.00
24_V137_E1.6221.00
109_E140_R1.5991.00
57_T60_G1.5861.00
100_D103_R1.5291.00
121_S135_A1.5081.00
124_D131_T1.4901.00
42_T120_I1.4881.00
47_A89_Q1.4831.00
24_V114_P1.4451.00
58_I83_F1.4291.00
55_D62_K1.4021.00
84_N100_D1.4021.00
3_R20_S1.3811.00
79_W141_V1.3691.00
133_V140_R1.3411.00
75_G78_E1.3351.00
42_T134_L1.3051.00
132_L145_I1.3031.00
126_T129_S1.2921.00
111_L115_V1.2901.00
73_I82_I1.2691.00
30_F139_T1.2631.00
41_R91_G1.2621.00
14_D53_S1.2601.00
17_I132_L1.2411.00
95_Y100_D1.2341.00
131_T142_S1.2311.00
82_I103_R1.2291.00
115_V135_A1.2031.00
85_K101_V1.2001.00
3_R18_D1.1961.00
71_F92_S1.1941.00
47_A69_T1.1801.00
122_F132_L1.1671.00
24_V29_I1.1621.00
111_L114_P1.1391.00
70_L81_L1.1311.00
72_T81_L1.1311.00
37_G76_E1.1281.00
80_T103_R1.1171.00
21_R117_T1.1121.00
120_I134_L1.1011.00
69_T84_N1.0821.00
106_V141_V1.0701.00
13_T54_K1.0601.00
13_T53_S1.0601.00
121_S133_V1.0521.00
7_S14_D1.0461.00
104_V143_V1.0391.00
64_P101_V1.0341.00
4_A21_R1.0331.00
29_I33_L1.0301.00
30_F34_V1.0171.00
5_T18_D1.0171.00
2_P23_S1.0101.00
59_G106_V1.0091.00
63_L101_V1.0071.00
59_G104_V1.0061.00
122_F130_A1.0011.00
114_P138_K0.9951.00
120_I132_L0.9911.00
95_Y103_R0.9831.00
83_F102_L0.9821.00
86_Q89_Q0.9811.00
111_L140_R0.9731.00
35_P38_K0.9481.00
49_T87_T0.9411.00
115_V119_T0.9391.00
39_V92_S0.9351.00
64_P85_K0.9261.00
111_L135_A0.9221.00
61_K104_V0.9201.00
31_G36_Y0.9191.00
133_V142_S0.9141.00
71_F93_F0.8971.00
81_L106_V0.8941.00
119_T135_A0.8841.00
52_F63_L0.8841.00
7_S16_T0.8831.00
24_V30_F0.8801.00
63_L102_L0.8781.00
109_E142_S0.8771.00
75_G105_K0.8671.00
89_Q94_E0.8631.00
39_V82_I0.8491.00
125_V130_A0.8481.00
29_I137_E0.8461.00
83_F101_V0.8421.00
82_I100_D0.8381.00
15_I50_I0.8281.00
75_G80_T0.8211.00
73_I80_T0.8191.00
73_I103_R0.8191.00
114_P137_E0.8151.00
69_T87_T0.8121.00
70_L83_F0.8091.00
78_E107_K0.8081.00
16_T51_T0.8001.00
90_W93_F0.7831.00
21_R119_T0.7811.00
134_L141_V0.7781.00
79_W108_P0.7731.00
41_R45_N0.7661.00
108_P141_V0.7601.00
50_I83_F0.7531.00
41_R90_W0.7511.00
83_F104_V0.7441.00
36_Y76_E0.7431.00
34_V37_G0.7421.00
30_F79_W0.7421.00
86_Q96_D0.7261.00
24_V28_K0.7231.00
8_Q122_F0.7211.00
71_F89_Q0.7181.00
46_E49_T0.7161.00
36_Y74_P0.7121.00
30_F33_L0.7101.00
67_T87_T0.7061.00
9_T12_G0.7011.00
10_V13_T0.7011.00
46_E90_W0.7001.00
97_E103_R0.7001.00
39_V95_Y0.6921.00
34_V74_P0.6921.00
130_A145_I0.6901.00
77_D107_K0.6901.00
29_I34_V0.6771.00
81_L143_V0.6761.00
47_A87_T0.6731.00
106_V143_V0.6681.00
49_T69_T0.6671.00
59_G102_L0.6671.00
43_G48_T0.6641.00
9_T13_T0.6601.00
24_V31_G0.6591.00
45_N90_W0.6591.00
50_I56_V0.6571.00
5_T16_T0.6501.00
108_P139_T0.6471.00
42_T91_G0.6441.00
21_R125_V0.6421.00
30_F137_E0.6401.00
4_A8_Q0.6371.00
84_N95_Y0.6351.00
17_I120_I0.6241.00
84_N99_K0.6211.00
71_F91_G0.6131.00
69_T89_Q0.6111.00
84_N89_Q0.6111.00
3_R45_N0.6101.00
10_V130_A0.6071.00
28_K31_G0.6011.00
111_L138_K0.5991.00
38_K73_I0.5971.00
50_I70_L0.5941.00
67_T88_G0.5911.00
58_I104_V0.5901.00
72_T134_L0.5901.00
92_S95_Y0.5901.00
28_K137_E0.5851.00
79_W139_T0.5821.00
15_I52_F0.5731.00
117_T125_V0.5721.00
56_V63_L0.5711.00
18_D49_T0.5661.00
81_L104_V0.5651.00
46_E88_G0.5591.00
70_L134_L0.5581.00
38_K74_P0.5561.00
16_T49_T0.5541.00
15_I56_V0.5541.00
16_T53_S0.5481.00
115_V140_R0.5481.00
4_A7_S0.5471.00
6_V122_F0.5471.00
12_G54_K0.5451.00
47_A88_G0.5441.00
131_T144_P0.5431.00
81_L141_V0.5391.00
4_A20_S0.5371.00
31_G34_V0.5371.00
89_Q92_S0.5361.00
39_V71_F0.5341.00
47_A90_W0.5341.00
56_V145_I0.5261.00
61_K105_K0.5261.00
20_S45_N0.5211.00
27_R44_A0.5211.00
47_A71_F0.5211.00
69_T86_Q0.5181.00
58_I143_V0.5131.00
24_V34_V0.5031.00
142_S145_I0.5011.00
115_V121_S0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1lyqA 1 0.6138 36.5 0.917 Contact Map
2c9rA 1 0.5931 28.6 0.921 Contact Map
4a2lA 4 0.5379 7.2 0.94 Contact Map
4d1iA 4 0.7172 6.7 0.941 Contact Map
3rfzB 2 0.5724 6.4 0.942 Contact Map
3v9fA 1 0.5379 5.8 0.943 Contact Map
3ottA 2 0.6414 5.5 0.943 Contact Map
3wtdA 2 0.5793 5.4 0.944 Contact Map
3wtfA 2 0.5793 4.9 0.944 Contact Map
3u7vA 3 0.7034 4.8 0.945 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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