GREMLIN Database
DUF2909 - Protein of unknown function (DUF2909)
PFAM: PF11137 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 60 (60)
Sequences: 7672 (4111)
Seq/√Len: 530.8
META: 0.923

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
23_L33_M3.1361.00
34_V38_T2.9121.00
31_K35_K2.2411.00
6_V10_L2.1041.00
54_A59_W2.0171.00
53_L57_L1.9731.00
19_A36_A1.7211.00
12_I44_S1.7071.00
26_D30_S1.5871.00
39_V43_L1.5041.00
49_L53_L1.4961.00
12_I47_L1.4761.00
35_K38_T1.4541.00
21_F25_R1.4421.00
3_I7_L1.3751.00
48_F52_L1.3611.00
18_S22_F1.3561.00
15_S39_V1.2411.00
22_F32_R1.2391.00
4_L8_L1.2361.00
26_D32_R1.1991.00
10_L14_A1.1831.00
50_L54_A1.1791.00
14_A39_V1.1761.00
12_I43_L1.1721.00
17_G20_L1.1511.00
38_T41_V1.1511.00
42_G46_A1.1491.00
11_A43_L1.1431.00
14_A18_S1.1301.00
52_L56_Y1.1101.00
17_G21_F1.0551.00
4_L50_L1.0481.00
54_A57_L1.0331.00
38_T42_G1.0301.00
6_V9_L1.0281.00
13_L17_G1.0251.00
8_L47_L1.0221.00
35_K39_V0.9861.00
9_L13_L0.9681.00
39_V42_G0.9391.00
22_F26_D0.9061.00
53_L56_Y0.8901.00
7_L11_A0.8821.00
19_A33_M0.8721.00
46_A50_L0.8581.00
15_S18_S0.8551.00
45_V48_F0.8541.00
8_L11_A0.8231.00
27_K30_S0.8161.00
14_A17_G0.8131.00
17_G24_V0.7971.00
15_S20_L0.7661.00
18_S21_F0.7641.00
20_L24_V0.7641.00
44_S48_F0.7551.00
8_L46_A0.7321.00
1_M54_A0.7241.00
11_A15_S0.7111.00
1_M59_W0.7081.00
13_L16_L0.7051.00
21_F24_V0.6831.00
19_A22_F0.6721.00
52_L55_Y0.6481.00
47_L50_L0.6391.00
45_V49_L0.6361.00
41_V48_F0.6281.00
22_F36_A0.6251.00
53_L59_W0.6221.00
50_L59_W0.5870.99
5_I60_I0.5780.99
33_M37_L0.5720.99
56_Y59_W0.5670.99
42_G45_V0.5660.99
51_L55_Y0.5610.99
33_M36_A0.5580.99
43_L48_F0.5580.99
34_V45_V0.5530.99
2_K6_V0.5510.99
41_V44_S0.5380.99
31_K34_V0.5340.99
11_A14_A0.5330.99
28_G32_R0.5320.99
18_S32_R0.5310.99
55_Y59_W0.5270.99
9_L41_V0.5200.99
42_G49_L0.5140.99
24_V33_M0.5110.99
3_I6_V0.5090.98
20_L43_L0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2lonA 1 0.9833 82.2 0.719 Contact Map
2lomA 1 0.9833 78.8 0.728 Contact Map
4ev6A 3 0.9 22.1 0.814 Contact Map
4i0uA 4 0.8667 16.7 0.825 Contact Map
1rz2A 1 0.0167 9.8 0.842 Contact Map
4p02B 1 0.45 6.2 0.856 Contact Map
1zoyC 1 0.9167 5.3 0.86 Contact Map
2kseA 1 0.55 4.5 0.864 Contact Map
2wdqC 1 0.9333 4.4 0.866 Contact Map
2h88C 2 0.9167 4.4 0.866 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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