GREMLIN Database
DUF2889 - Protein of unknown function (DUF2889)
PFAM: PF11136 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 123 (123)
Sequences: 6338 (4173)
Seq/√Len: 376.3
META: 0.937

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
66_M69_L4.1401.00
61_D85_V3.1391.00
96_A100_R2.8061.00
22_H46_D2.7301.00
96_A99_E2.5391.00
82_Q85_V2.4361.00
46_D68_A2.4351.00
87_L96_A2.2801.00
54_D58_T2.0461.00
61_D82_Q2.0341.00
51_L62_A1.9351.00
30_D39_P1.9171.00
52_T61_D1.9021.00
81_Y111_T1.8931.00
83_R105_R1.8871.00
58_T88_R1.8001.00
2_T6_R1.7811.00
54_D60_V1.7641.00
16_L60_V1.7571.00
48_W67_D1.7291.00
32_G37_E1.6951.00
48_W65_V1.6451.00
50_R63_E1.6061.00
22_H48_W1.5861.00
2_T8_D1.5561.00
18_D52_T1.5521.00
87_L100_R1.5111.00
19_I51_L1.5031.00
12_R18_D1.4991.00
30_D40_A1.4811.00
80_A83_R1.4691.00
30_D37_E1.4511.00
69_L75_P1.4471.00
59_I93_F1.4461.00
39_P42_E1.4081.00
20_E50_R1.4061.00
24_T46_D1.3901.00
66_M78_A1.3691.00
33_L36_G1.3651.00
75_P78_A1.3541.00
88_R91_P1.3351.00
53_V89_I1.3341.00
46_D67_D1.2851.00
95_R99_E1.2851.00
83_R100_R1.2391.00
51_L59_I1.1941.00
116_A120_A1.1891.00
7_C116_A1.1751.00
51_L117_L1.1551.00
95_R98_R1.1511.00
49_L113_L1.1361.00
33_L38_R1.0901.00
16_L52_T1.0761.00
94_R98_R1.0721.00
18_D50_R1.0681.00
49_L114_L1.0571.00
35_D72_G1.0531.00
81_Y101_L1.0311.00
79_P82_Q1.0151.00
47_M66_M1.0141.00
94_R97_V1.0101.00
26_T43_P1.0091.00
50_R65_V0.9861.00
77_I81_Y0.9851.00
21_G113_L0.9851.00
64_A110_L0.9761.00
77_I80_A0.9761.00
4_R8_D0.9571.00
72_G75_P0.9541.00
49_L110_L0.9461.00
13_D16_L0.9451.00
94_R115_R0.9421.00
4_R26_T0.9321.00
64_A78_A0.9291.00
12_R16_L0.9281.00
42_E68_A0.9201.00
97_V111_T0.9071.00
12_R52_T0.9061.00
80_A105_R0.8951.00
19_I121_A0.8891.00
63_E82_Q0.8871.00
62_A82_Q0.8871.00
65_V78_A0.8721.00
7_C120_A0.8711.00
26_T41_G0.8641.00
43_P68_A0.8581.00
93_F118_A0.8551.00
17_W55_D0.8521.00
22_H67_D0.8471.00
9_G19_I0.8341.00
112_E119_T0.8321.00
102_G105_R0.8231.00
38_R44_V0.8211.00
31_F38_R0.8191.00
64_A81_Y0.8161.00
102_G106_G0.8151.00
113_L116_A0.7981.00
62_A101_L0.7961.00
24_T43_P0.7811.00
93_F114_L0.7761.00
80_A106_G0.7751.00
114_L117_L0.7691.00
73_E76_E0.7671.00
84_L87_L0.7651.00
111_T115_R0.7441.00
31_F44_V0.7331.00
35_D73_E0.7321.00
12_R15_G0.7221.00
18_D53_V0.7221.00
98_R111_T0.7171.00
28_T41_G0.7161.00
77_I101_L0.7141.00
67_D70_P0.6830.99
27_K71_Y0.6760.99
69_L78_A0.6760.99
27_K31_F0.6730.99
20_E48_W0.6710.99
89_I118_A0.6680.99
76_E79_P0.6660.99
19_I53_V0.6600.99
98_R115_R0.6580.99
5_I9_G0.6540.99
83_R101_L0.6520.99
11_R55_D0.6490.99
53_V121_A0.6430.99
116_A119_T0.6400.99
10_Y18_D0.6350.99
62_A85_V0.6330.99
89_I121_A0.6280.99
33_L37_E0.6260.99
9_G12_R0.6250.99
92_G96_A0.6210.99
111_T116_A0.6150.99
21_G117_L0.6140.99
66_M70_P0.6140.99
47_M110_L0.6130.99
5_I116_A0.6120.99
51_L89_I0.6080.99
97_V115_R0.6030.98
97_V114_L0.5970.98
108_T112_E0.5960.98
2_T26_T0.5950.98
87_L93_F0.5890.98
101_L106_G0.5870.98
32_G38_R0.5830.98
10_Y20_E0.5780.98
45_H70_P0.5750.98
74_C107_C0.5740.98
56_D60_V0.5730.98
103_G106_G0.5730.98
4_R24_T0.5700.98
72_G76_E0.5650.98
92_G99_E0.5630.98
92_G118_A0.5630.98
36_G71_Y0.5580.97
32_G35_D0.5570.97
27_K42_E0.5500.97
112_E116_A0.5460.97
7_C17_W0.5450.97
6_R22_H0.5440.97
47_M69_L0.5440.97
80_A101_L0.5420.97
38_R42_E0.5380.97
64_A77_I0.5370.97
15_G52_T0.5280.96
53_V57_L0.5270.96
43_P46_D0.5270.96
16_L50_R0.5250.96
90_G122_F0.5240.96
21_G51_L0.5210.96
29_Y36_G0.5200.96
10_Y14_D0.5190.96
81_Y106_G0.5190.96
118_A122_F0.5190.96
91_P96_A0.5190.96
33_L39_P0.5170.96
26_T40_A0.5170.96
69_L73_E0.5160.96
23_L44_V0.5130.96
66_M110_L0.5120.96
90_G94_R0.5120.96
23_L110_L0.5110.96
35_D69_L0.5000.95
108_T111_T0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1atiA 2 0.3821 11.2 0.92 Contact Map
1a3qA 2 0.561 4.8 0.932 Contact Map
2cs4A 1 0.6098 3.5 0.936 Contact Map
3cnxA 2 0.2358 3.5 0.937 Contact Map
4nq3A 4 0.4878 3.3 0.937 Contact Map
2idbA 3 0.9106 2.9 0.939 Contact Map
2uwqA 1 0.6016 2.9 0.939 Contact Map
3f7sA 2 0.3333 2.6 0.94 Contact Map
3hugB 2 0.4065 2.6 0.94 Contact Map
2gj4A 2 0.374 2.4 0.941 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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