GREMLIN Database
DUF2887 - Protein of unknown function (DUF2887)
PFAM: PF11103 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 200 (200)
Sequences: 1141 (830)
Seq/√Len: 58.7
META: 0.691

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
114_E120_R5.8511.00
102_R128_E4.7811.00
99_Y106_P3.8581.00
72_F76_L3.2951.00
92_D113_R3.2231.00
36_E43_R3.1271.00
77_F121_V2.7991.00
36_E41_A2.7001.00
69_D75_R2.6371.00
76_L95_A2.6371.00
182_T186_Y2.6261.00
44_I72_F2.6081.00
75_R79_E2.5951.00
81_F115_L2.3451.00
80_I95_A2.2691.00
71_D88_P2.2501.00
16_L60_Y2.2301.00
3_S39_E2.1031.00
5_F8_L1.9161.00
194_E197_E1.8981.00
24_P27_A1.8861.00
69_D79_E1.8571.00
185_V196_I1.8481.00
74_W85_R1.8090.99
195_E199_M1.7960.99
100_P104_L1.7430.99
114_E119_G1.7410.99
49_L59_I1.7340.99
105_E123_R1.7030.99
44_I79_E1.6670.99
42_F82_L1.6390.99
66_F100_P1.6270.99
193_R197_E1.5900.99
94_Q122_R1.5860.99
99_Y105_E1.5850.99
42_F85_R1.5360.98
47_V59_I1.5240.98
61_F112_Y1.5180.98
156_A200_L1.5120.98
100_P106_P1.5100.98
44_I47_V1.5090.98
153_P157_R1.5070.98
61_F80_I1.4880.98
61_F95_A1.4810.98
71_D89_P1.4720.98
125_Y128_E1.4440.97
68_P107_G1.3760.96
18_E136_S1.3520.96
181_E189_P1.3490.96
65_Q75_R1.3430.96
140_A162_R1.3380.96
72_F97_V1.3150.95
101_S104_L1.2960.95
76_L80_I1.2890.95
116_L121_V1.2830.95
114_E118_S1.2810.95
61_F83_Y1.2770.95
135_L143_K1.2640.94
152_A156_A1.2630.94
147_E151_E1.2610.94
35_V47_V1.2510.94
113_R117_N1.2500.94
98_I117_N1.2290.93
163_A167_I1.2110.93
113_R120_R1.2080.93
77_F81_F1.1950.92
149_E157_R1.1950.92
9_F13_P1.1810.92
152_A184_L1.1770.92
140_A143_K1.1690.92
89_P111_P1.1690.92
4_I187_K1.1680.92
143_K147_E1.1630.91
39_E82_L1.1580.91
37_V44_I1.1400.91
71_D85_R1.1380.90
39_E186_Y1.1280.90
32_F79_E1.1170.90
16_L48_F1.1160.90
182_T188_F1.1110.89
17_F23_P1.1090.89
38_K45_D1.1050.89
16_L20_L1.1050.89
67_Q104_L1.1030.89
163_A168_L1.0980.89
32_F46_G1.0980.89
81_F112_Y1.0900.88
92_D110_P1.0880.88
95_A121_V1.0750.88
22_Q26_N1.0630.87
188_F196_I1.0530.87
42_F79_E1.0500.87
73_Y125_Y1.0490.87
73_Y105_E1.0480.86
147_E155_Q1.0290.85
185_V192_S1.0280.85
130_G135_L1.0240.85
40_T43_R1.0180.85
160_L180_I1.0010.84
78_A81_F0.9950.83
2_D5_F0.9830.83
69_D72_F0.9830.83
69_D97_V0.9760.82
118_S121_V0.9750.82
74_W88_P0.9670.82
48_F76_L0.9630.81
23_P28_G0.9570.81
40_T61_F0.9520.81
77_F112_Y0.9460.80
67_Q79_E0.9450.80
181_E185_V0.9330.79
78_A82_L0.9330.79
37_V82_L0.9320.79
7_R39_E0.9310.79
72_F80_I0.9300.79
91_R111_P0.9130.78
5_F64_V0.9040.77
114_E117_N0.9010.77
9_F18_E0.8980.77
132_I135_L0.8940.76
69_D99_Y0.8940.76
185_V189_P0.8920.76
68_P106_P0.8890.76
180_I183_I0.8860.76
139_L143_K0.8830.75
67_Q100_P0.8810.75
20_L98_I0.8770.75
31_R51_P0.8670.74
33_S86_Q0.8650.74
23_P26_N0.8640.74
19_L129_L0.8620.74
35_V87_N0.8610.74
67_Q75_R0.8530.73
139_L142_L0.8460.72
87_N111_P0.8330.71
136_S143_K0.8270.71
8_L16_L0.8220.70
34_S44_I0.8150.69
101_S127_D0.8140.69
117_N155_Q0.8120.69
4_I9_F0.8080.69
33_S47_V0.8040.68
92_D120_R0.8000.68
12_F16_L0.7990.68
44_I69_D0.7980.68
68_P161_E0.7910.67
152_A197_E0.7880.67
141_L196_I0.7880.67
3_S72_F0.7870.67
1_T11_T0.7790.66
42_F78_A0.7750.65
14_S18_E0.7740.65
159_L180_I0.7720.65
182_T196_I0.7720.65
102_R116_L0.7700.65
32_F76_L0.7680.65
59_I83_Y0.7660.65
172_L184_L0.7640.64
135_L162_R0.7610.64
112_Y115_L0.7590.64
33_S37_V0.7590.64
145_I187_K0.7580.64
192_S195_E0.7580.64
181_E194_E0.7550.63
13_P75_R0.7540.63
84_L112_Y0.7510.63
69_D200_L0.7500.63
78_A85_R0.7480.63
37_V96_V0.7470.63
133_P140_A0.7430.62
82_L85_R0.7430.62
73_Y77_F0.7410.62
5_F9_F0.7360.61
16_L21_G0.7320.61
137_L163_A0.7290.61
74_W84_L0.7280.61
5_F18_E0.7250.60
13_P17_F0.7190.60
148_P151_E0.7160.59
3_S40_T0.7120.59
150_E192_S0.7120.59
163_A166_E0.7070.58
16_L24_P0.7060.58
115_L121_V0.7010.58
194_E200_L0.6940.57
156_A196_I0.6940.57
166_E169_D0.6840.56
37_V132_I0.6840.56
129_L139_L0.6800.55
37_V76_L0.6760.55
110_P161_E0.6740.55
149_E189_P0.6720.55
191_L196_I0.6680.54
39_E111_P0.6660.54
29_G57_G0.6640.54
136_S162_R0.6610.53
88_P111_P0.6600.53
94_Q117_N0.6590.53
4_I179_L0.6570.53
60_Y128_E0.6570.53
1_T58_P0.6530.52
16_L25_E0.6520.52
159_L162_R0.6490.52
171_A176_L0.6460.52
84_L93_W0.6440.51
176_L188_F0.6410.51
102_R149_E0.6410.51
103_S108_D0.6400.51
70_E88_P0.6390.51
155_Q161_E0.6320.50
116_L123_R0.6310.50
40_T87_N0.6300.50
20_L113_R0.6290.50
7_R22_Q0.6290.50
52_E57_G0.6280.50
31_R171_A0.6270.50
48_F60_Y0.6270.50
2_D6_Y0.6240.49
153_P156_A0.6220.49
34_S62_V0.6210.49
87_N136_S0.6200.49
151_E158_Q0.6190.49
77_F115_L0.6180.49
196_I199_M0.6140.48
48_F62_V0.6130.48
133_P150_E0.6130.48
150_E153_P0.6120.48
40_T182_T0.6120.48
25_E28_G0.6070.47
37_V56_D0.6050.47
20_L31_R0.6030.47
172_L177_L0.5990.46
72_F105_E0.5960.46
170_E174_R0.5960.46
150_E157_R0.5920.46
15_L20_L0.5900.45
78_A121_V0.5890.45
46_G58_P0.5870.45
85_R200_L0.5820.45
65_Q69_D0.5810.44
55_P166_E0.5780.44
98_I142_L0.5780.44
74_W111_P0.5770.44
154_E161_E0.5740.44
15_L60_Y0.5720.43
42_F182_T0.5710.43
94_Q121_V0.5710.43
56_D164_Q0.5710.43
6_Y61_F0.5690.43
31_R151_E0.5690.43
157_R185_V0.5660.43
183_I187_K0.5650.43
137_L184_L0.5630.43
73_Y123_R0.5610.42
180_I190_Q0.5610.42
40_T85_R0.5610.42
62_V161_E0.5600.42
36_E40_T0.5600.42
135_L169_D0.5570.42
110_P113_R0.5550.42
87_N109_P0.5540.42
16_L147_E0.5530.41
17_F60_Y0.5520.41
155_Q159_L0.5490.41
16_L27_A0.5490.41
185_V193_R0.5470.41
75_R85_R0.5450.41
3_S18_E0.5390.40
37_V150_E0.5350.40
58_P142_L0.5350.40
15_L25_E0.5330.39
102_R131_E0.5330.39
25_E51_P0.5320.39
7_R11_T0.5310.39
77_F183_I0.5290.39
55_P194_E0.5260.39
14_S33_S0.5240.38
68_P104_L0.5220.38
11_T151_E0.5210.38
82_L93_W0.5180.38
105_E193_R0.5170.38
124_I172_L0.5160.38
184_L200_L0.5160.38
50_P100_P0.5130.37
138_G160_L0.5120.37
15_L30_Y0.5110.37
103_S122_R0.5110.37
53_E57_G0.5100.37
28_G31_R0.5100.37
196_I200_L0.5100.37
101_S143_K0.5090.37
4_I40_T0.5080.37
2_D9_F0.5060.36
107_G119_G0.5060.36
5_F30_Y0.5060.36
169_D172_L0.5050.36
7_R178_E0.5030.36
16_L22_Q0.5010.36
136_S142_L0.5000.36
83_Y89_P0.5000.36
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2f4mB 1 0.125 11 0.955 Contact Map
2xppB 1 0.095 7.9 0.958 Contact Map
1pveA 1 0.17 6.5 0.959 Contact Map
4r1kA 1 0.245 5.6 0.961 Contact Map
2d58A 1 0.37 5.6 0.961 Contact Map
1w9cA 2 0.35 5.4 0.961 Contact Map
4gtnA 2 0.31 5.3 0.961 Contact Map
2kkpA 1 0.285 4.5 0.962 Contact Map
2yb5A 1 0.47 4.5 0.963 Contact Map
2xpnB 1 0.1 4.5 0.963 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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