GREMLIN Database
DUF2884 - Protein of unknown function (DUF2884)
PFAM: PF11101 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 228 (227)
Sequences: 845 (576)
Seq/√Len: 38.2
META: 0.555

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
34_L41_V4.8061.00
71_E197_R4.6861.00
24_P27_V3.4671.00
64_E197_R3.1831.00
43_L51_L3.0491.00
34_L51_L2.9861.00
32_G55_E2.6531.00
221_E225_L2.6301.00
209_D226_D2.5841.00
75_I187_V2.4811.00
11_I59_R2.3751.00
72_G76_A2.3711.00
35_F40_A2.2911.00
43_L47_Q2.2741.00
134_F138_F2.2510.99
79_A83_V2.2260.99
155_Q158_G2.1660.99
82_E186_E2.1420.99
123_G127_F2.0430.99
63_P69_A2.0130.99
64_E204_R1.9840.99
47_Q218_R1.9570.98
183_I187_V1.9370.98
207_A210_E1.9350.98
44_S47_Q1.9300.98
149_S153_I1.9000.98
105_L110_K1.8820.98
150_V161_M1.8590.98
172_L176_M1.8570.98
24_P29_N1.8380.98
158_G162_L1.8260.98
29_N33_Q1.8240.98
106_K109_L1.7930.97
58_L203_P1.7900.97
98_L105_L1.7890.97
23_G26_L1.7470.97
33_Q40_A1.7340.97
101_L106_K1.7180.97
12_D138_F1.7020.96
43_L52_R1.6850.96
141_A149_S1.6610.96
36_V41_V1.6230.95
57_G207_A1.6170.95
219_I222_L1.5790.94
166_G169_L1.5780.94
89_G92_S1.5740.94
27_V35_F1.5730.94
154_L176_M1.5350.93
32_G47_Q1.5070.93
146_V171_A1.4980.93
109_L112_R1.4760.92
140_Q150_V1.4660.92
190_R209_D1.4590.92
102_L106_K1.4460.91
134_F140_Q1.4430.91
68_I71_E1.4410.91
49_Q53_E1.4400.91
10_T17_E1.3960.90
155_Q162_L1.3710.89
54_Y212_E1.3630.89
142_V183_I1.3550.88
71_E139_E1.3540.88
155_Q159_N1.3530.88
179_L183_I1.3530.88
83_V87_L1.3520.88
80_L122_L1.3440.88
37_D52_R1.3350.88
153_I158_G1.2960.86
88_L94_A1.2730.85
16_L59_R1.2710.85
192_Q207_A1.2680.85
47_Q50_R1.2650.85
84_A88_L1.2630.84
222_L227_L1.2590.84
26_L29_N1.2580.84
43_L212_E1.2530.84
41_V51_L1.2390.83
68_I75_I1.2340.83
72_G197_R1.2210.82
157_A160_A1.2110.82
212_E226_D1.1910.81
104_Q107_A1.1800.80
83_V191_A1.1610.79
112_R116_S1.1570.79
142_V146_V1.1340.77
137_E150_V1.1270.77
26_L47_Q1.1140.76
223_K226_D1.1130.76
189_A206_Q1.1010.75
18_F26_L1.0980.75
185_A189_A1.0920.75
106_K110_K1.0750.73
109_L159_N1.0730.73
24_P28_I1.0700.73
138_F143_E1.0630.73
28_I55_E1.0610.72
211_L223_K1.0610.72
103_D107_A1.0590.72
104_Q108_Q1.0550.72
123_G126_A1.0550.72
68_I198_A1.0540.72
74_D78_D1.0500.72
55_E59_R1.0470.71
120_F123_G1.0380.71
47_Q55_E1.0310.70
117_G225_L1.0280.70
178_G182_E1.0250.70
101_L183_I1.0220.70
177_E192_Q1.0170.69
37_D46_A1.0100.69
23_G128_D1.0080.68
53_E60_A1.0060.68
43_L48_Q1.0040.68
212_E217_Q1.0000.68
145_L153_I0.9990.68
67_A197_R0.9910.67
62_V159_N0.9800.66
11_I62_V0.9740.66
13_P93_N0.9710.66
12_D15_S0.9670.65
219_I224_P0.9660.65
194_L198_A0.9610.65
27_V130_F0.9590.65
13_P59_R0.9520.64
79_A208_L0.9440.63
113_I209_D0.9440.63
184_E212_E0.9420.63
151_G155_Q0.9360.63
71_E191_A0.9350.63
59_R69_A0.9340.62
145_L159_N0.9300.62
84_A188_E0.9290.62
69_A73_V0.9280.62
22_G53_E0.9270.62
214_Q217_Q0.9170.61
46_A53_E0.9150.61
156_A160_A0.9120.61
222_L225_L0.9100.60
192_Q200_A0.9100.60
39_K192_Q0.9090.60
18_F211_L0.9060.60
94_A98_L0.8980.59
71_E190_R0.8930.59
191_A198_A0.8930.59
93_N171_A0.8860.58
132_D135_E0.8830.58
95_R99_T0.8810.58
43_L63_P0.8660.57
211_L226_D0.8610.56
42_A46_A0.8520.55
186_E220_P0.8510.55
14_D183_I0.8460.55
50_R55_E0.8410.54
20_R105_L0.8380.54
160_A164_G0.8360.54
93_N100_A0.8330.54
62_V120_F0.8300.53
110_K113_I0.8270.53
169_L172_L0.8250.53
209_D213_Q0.8200.53
66_K80_L0.8090.52
94_A101_L0.8060.51
22_G28_I0.8040.51
102_L105_L0.8040.51
76_A80_L0.8030.51
58_L126_A0.8030.51
54_Y62_V0.8020.51
113_I122_L0.8020.51
191_A195_E0.7990.51
75_I190_R0.7910.50
5_S222_L0.7900.50
69_A72_G0.7890.50
10_T16_L0.7880.50
3_V183_I0.7870.50
172_L175_R0.7820.49
154_L158_G0.7820.49
86_G94_A0.7750.48
71_E75_I0.7740.48
106_K111_R0.7730.48
115_Q118_D0.7730.48
122_L145_L0.7720.48
199_E219_I0.7700.48
214_Q224_P0.7640.48
187_V191_A0.7630.47
43_L76_A0.7630.47
113_I116_S0.7610.47
151_G193_A0.7570.47
37_D225_L0.7560.47
184_E195_E0.7560.47
192_Q195_E0.7530.47
41_V187_V0.7520.46
58_L87_L0.7510.46
87_L148_E0.7500.46
32_G50_R0.7490.46
36_V139_E0.7470.46
138_F147_P0.7460.46
42_A178_G0.7440.46
143_E158_G0.7340.45
105_L113_I0.7330.45
103_D106_K0.7290.44
49_Q87_L0.7280.44
40_A48_Q0.7240.44
160_A190_R0.7230.44
210_E224_P0.7130.43
111_R221_E0.7080.43
172_L180_G0.7020.42
136_Q159_N0.6980.42
50_R74_D0.6970.42
14_D132_D0.6960.41
80_L90_D0.6940.41
177_E180_G0.6940.41
10_T19_T0.6920.41
133_A137_E0.6900.41
48_Q52_R0.6900.41
50_R218_R0.6890.41
131_D136_Q0.6860.41
39_K45_A0.6830.40
39_K188_E0.6800.40
163_S172_L0.6790.40
137_E140_Q0.6780.40
64_E186_E0.6780.40
16_L20_R0.6750.40
62_V66_K0.6710.39
32_G44_S0.6710.39
34_L200_A0.6660.39
65_V69_A0.6660.39
138_F141_A0.6640.39
152_S156_A0.6590.38
213_Q226_D0.6570.38
7_Y20_R0.6550.38
54_Y58_L0.6550.38
66_K109_L0.6540.38
144_E148_E0.6510.38
26_L30_H0.6450.37
33_Q191_A0.6450.37
158_G161_M0.6440.37
65_V76_A0.6440.37
214_Q226_D0.6440.37
7_Y123_G0.6430.37
151_G154_L0.6430.37
209_D212_E0.6430.37
172_L195_E0.6430.37
182_E186_E0.6420.37
146_V154_L0.6390.37
48_Q182_E0.6380.37
186_E201_L0.6380.37
160_A168_N0.6370.36
101_L114_Y0.6360.36
128_D143_E0.6340.36
161_M168_N0.6340.36
95_R179_L0.6320.36
165_D172_L0.6290.36
102_L146_V0.6230.35
160_A167_D0.6220.35
136_Q139_E0.6210.35
173_E176_M0.6190.35
34_L47_Q0.6120.34
135_E153_I0.6110.34
195_E220_P0.6100.34
139_E173_E0.6090.34
155_Q180_G0.6060.34
85_A135_E0.6060.34
174_A177_E0.6060.34
4_D46_A0.6040.34
99_T113_I0.6030.34
44_S128_D0.6020.34
72_G193_A0.5990.33
34_L129_Q0.5950.33
169_L173_E0.5950.33
83_V183_I0.5940.33
172_L183_I0.5930.33
83_V128_D0.5900.33
34_L100_A0.5900.33
108_Q188_E0.5900.33
18_F47_Q0.5880.33
133_A138_F0.5870.32
55_E113_I0.5850.32
3_V127_F0.5850.32
51_L55_E0.5840.32
138_F153_I0.5840.32
16_L19_T0.5770.32
3_V19_T0.5740.31
217_Q222_L0.5700.31
68_I156_A0.5690.31
7_Y55_E0.5680.31
105_L112_R0.5680.31
156_A209_D0.5680.31
176_M180_G0.5640.31
51_L85_A0.5640.31
102_L112_R0.5640.31
134_F152_S0.5630.31
84_A157_A0.5620.30
47_Q222_L0.5620.30
52_R199_E0.5580.30
187_V201_L0.5500.30
33_Q195_E0.5500.30
187_V197_R0.5500.30
65_V165_D0.5490.30
56_R171_A0.5490.30
136_Q146_V0.5480.29
8_D186_E0.5480.29
28_I58_L0.5470.29
156_A164_G0.5460.29
65_V109_L0.5460.29
136_Q177_E0.5450.29
68_I186_E0.5420.29
154_L172_L0.5410.29
82_E86_G0.5400.29
131_D137_E0.5400.29
146_V183_I0.5400.29
171_A180_G0.5390.29
8_D71_E0.5370.29
109_L150_V0.5360.29
37_D108_Q0.5350.28
37_D139_E0.5350.28
188_E192_Q0.5350.28
113_I168_N0.5330.28
73_V169_L0.5320.28
72_G194_L0.5310.28
87_L109_L0.5300.28
187_V213_Q0.5300.28
74_D98_L0.5300.28
89_G154_L0.5290.28
57_G204_R0.5260.28
25_K71_E0.5230.28
11_I16_L0.5230.28
22_G208_L0.5230.28
84_A118_D0.5220.28
120_F157_A0.5210.27
149_S156_A0.5180.27
158_G172_L0.5170.27
217_Q225_L0.5170.27
41_V44_S0.5140.27
111_R157_A0.5130.27
185_A196_A0.5120.27
8_D164_G0.5040.26
62_V180_G0.5040.26
215_L219_I0.5040.26
16_L36_V0.5030.26
42_A45_A0.5000.26
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4etpB 1 0.2544 40.6 0.936 Contact Map
4etpA 1 0.2588 31.7 0.94 Contact Map
1mzkA 1 0.2851 28.7 0.941 Contact Map
3ounA 1 0.25 21.3 0.945 Contact Map
3uv0A 2 0.3026 21.3 0.945 Contact Map
3r2pA 2 0.6974 16.9 0.947 Contact Map
3rjpA 1 0.3904 16.8 0.947 Contact Map
3witA 3 0.2105 15.5 0.948 Contact Map
2hqnA 1 0.4474 14.8 0.949 Contact Map
4mtkA 4 0.3509 14.3 0.949 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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