GREMLIN Database
DUF2878 - Protein of unknown function (DUF2878)
PFAM: PF11086 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 155 (153)
Sequences: 3640 (2893)
Seq/√Len: 233.9
META: 0.833

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
11_G92_L4.1201.00
56_A91_A4.0801.00
62_V148_G3.3031.00
74_F86_L3.0001.00
60_L87_V2.6701.00
46_R50_R2.6411.00
114_L118_G2.4151.00
127_A132_V2.3731.00
56_A87_V2.3331.00
82_A86_L2.0991.00
37_L41_L2.0821.00
17_L129_L2.0661.00
9_Q13_F2.0571.00
116_A146_A2.0441.00
134_F141_A2.0321.00
4_N100_S2.0271.00
72_L132_V1.9771.00
64_S82_A1.8151.00
48_E99_H1.7851.00
48_E95_T1.7601.00
55_A94_A1.7531.00
71_L144_A1.6901.00
31_A88_A1.6771.00
124_L128_R1.6291.00
112_A150_A1.6181.00
127_A134_F1.6181.00
62_V152_L1.6021.00
42_S48_E1.5921.00
66_L148_G1.5751.00
102_R105_R1.5711.00
13_F17_L1.5681.00
8_F122_A1.5671.00
42_S45_R1.5531.00
2_L6_V1.5111.00
124_L127_A1.5041.00
48_E98_N1.4711.00
63_D123_Y1.4331.00
7_L34_F1.4261.00
47_R50_R1.3971.00
11_G34_F1.3691.00
115_G119_G1.3301.00
121_L125_A1.3291.00
143_L146_A1.2681.00
16_V132_V1.2641.00
28_P84_L1.2631.00
118_G122_A1.2561.00
38_H48_E1.2521.00
96_T100_S1.2391.00
86_L89_L1.2231.00
35_L39_L1.2211.00
111_A115_G1.2091.00
120_P146_A1.2001.00
98_N105_R1.2001.00
60_L82_A1.1981.00
4_N96_T1.1941.00
11_G15_C1.1871.00
65_L69_L1.1701.00
23_L26_L1.1671.00
67_V74_F1.1571.00
24_P27_G1.1461.00
116_A150_A1.1401.00
69_L73_S1.1151.00
52_L91_A1.0901.00
116_A120_P1.0881.00
136_D141_A1.0881.00
8_F96_T1.0591.00
15_C18_G1.0511.00
112_A154_P1.0481.00
141_A145_L1.0341.00
44_R47_R1.0311.00
137_P140_L1.0281.00
105_R108_P1.0271.00
4_N98_N1.0261.00
123_Y132_V1.0241.00
139_L143_L1.0091.00
5_F100_S1.0011.00
92_L95_T1.0001.00
28_P32_L0.9921.00
105_R154_P0.9911.00
146_A150_A0.9851.00
64_S68_A0.9791.00
25_W28_P0.9791.00
73_S135_P0.9751.00
5_F9_Q0.9711.00
7_L11_G0.9551.00
4_N99_H0.9431.00
9_Q100_S0.9421.00
134_F142_L0.9331.00
108_P112_A0.9191.00
45_R49_L0.9181.00
100_S103_W0.9171.00
82_A87_V0.9141.00
34_F92_L0.9131.00
117_I120_P0.9121.00
119_G122_A0.9021.00
15_C31_A0.8990.99
65_L68_A0.8970.99
104_L153_L0.8960.99
99_H102_R0.8890.99
59_G63_D0.8890.99
28_P31_A0.8810.99
142_L145_L0.8810.99
42_S99_H0.8790.99
148_G152_L0.8790.99
122_A125_A0.8770.99
151_L154_P0.8750.99
117_I121_L0.8700.99
38_H95_T0.8420.99
63_D74_F0.8380.99
101_L153_L0.8370.99
5_F103_W0.8350.99
6_V10_L0.8330.99
107_R110_L0.8280.99
35_L91_A0.8250.99
53_L57_L0.8140.99
60_L81_L0.8100.99
136_D139_L0.8090.99
51_L98_N0.8070.99
15_C88_A0.8060.99
63_D72_L0.8030.99
104_L114_L0.8000.99
3_I6_V0.7820.99
63_D86_L0.7810.99
96_T99_H0.7790.99
31_A92_L0.7770.99
63_D82_A0.7750.99
14_A18_G0.7720.98
86_L132_V0.7550.98
62_V65_L0.7500.98
74_F82_A0.7470.98
68_A80_G0.7410.98
66_L144_A0.7390.98
137_P142_L0.7380.98
126_G129_L0.7360.98
27_G31_A0.7330.98
15_C22_G0.7320.98
12_W16_V0.7300.98
9_Q125_A0.7300.98
4_N48_E0.7270.98
107_R111_A0.7270.98
34_F95_T0.7240.98
86_L145_L0.7200.98
30_A33_A0.7190.98
62_V66_L0.7180.98
4_N38_H0.7160.97
135_P139_L0.7110.97
71_L136_D0.7090.97
67_V80_G0.7000.97
14_A30_A0.6970.97
11_G30_A0.6960.97
147_L150_A0.6960.97
20_A131_A0.6960.97
118_G153_L0.6920.97
49_L53_L0.6900.97
8_F92_L0.6860.97
17_L20_A0.6710.96
34_F99_H0.6690.96
13_F125_A0.6670.96
77_P84_L0.6670.96
140_L143_L0.6660.96
119_G145_L0.6580.96
127_A130_G0.6530.96
18_G27_G0.6500.96
64_S81_L0.6480.96
50_R53_L0.6460.95
19_A131_A0.6460.95
124_L142_L0.6420.95
134_F145_L0.6330.95
126_G131_A0.6320.95
143_L147_L0.6310.95
78_P81_L0.6300.95
103_W119_G0.6290.95
27_G88_A0.6260.95
20_A130_G0.6250.95
119_G148_G0.6230.94
120_P145_L0.6220.94
71_L141_A0.6210.94
31_A35_L0.6130.94
68_A81_L0.6080.94
7_L37_L0.6080.94
15_C92_L0.6070.94
3_I7_L0.6070.94
56_A60_L0.6070.94
124_L138_L0.6060.94
32_L36_A0.6040.94
123_Y149_W0.6030.93
28_P88_A0.6020.93
66_L69_L0.6010.93
2_L5_F0.5970.93
145_L148_G0.5940.93
57_L61_L0.5920.93
109_L113_L0.5870.93
100_S123_Y0.5860.92
37_L40_A0.5800.92
46_R113_L0.5780.92
121_L124_L0.5740.92
144_A147_L0.5720.92
17_L21_H0.5710.91
18_G22_G0.5700.91
61_L79_P0.5700.91
77_P80_G0.5690.91
63_D145_L0.5680.91
52_L95_T0.5670.91
48_E100_S0.5640.91
4_N101_L0.5600.91
14_A27_G0.5570.90
47_R98_N0.5570.90
13_F129_L0.5550.90
38_H42_S0.5520.90
22_G25_W0.5510.90
46_R61_L0.5490.90
67_V132_V0.5450.90
29_L33_A0.5450.90
11_G14_A0.5410.89
47_R75_P0.5380.89
73_S133_T0.5380.89
62_V72_L0.5310.88
97_L123_Y0.5310.88
118_G121_L0.5290.88
76_S79_P0.5260.88
144_A148_G0.5260.88
108_P111_A0.5230.88
55_A152_L0.5190.87
19_A22_G0.5170.87
86_L126_G0.5160.87
39_L49_L0.5120.86
92_L99_H0.5120.86
94_A120_P0.5080.86
43_P47_R0.5050.86
55_A60_L0.5000.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4uc1A 3 0.6903 4.4 0.936 Contact Map
4ryoA 1 0.6452 3.1 0.94 Contact Map
4m5bA 1 0.5032 2.3 0.945 Contact Map
4mt1A 3 0.3484 1.3 0.952 Contact Map
1xc0A 1 0.2129 1.3 0.952 Contact Map
4k0jA 3 0.3613 1.2 0.953 Contact Map
3w9iA 3 0.3548 1.2 0.953 Contact Map
4dx5A 3 0.3548 1.1 0.954 Contact Map
4czbA 2 0.8452 1.1 0.954 Contact Map
3orgA 2 0.3548 0.9 0.956 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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