GREMLIN Database
DUF2780 - Protein of unknown function VcgC/VcgE (DUF2780)
PFAM: PF11075 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 175 (157)
Sequences: 728 (538)
Seq/√Len: 42.9
META: 0.714

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
74_L133_L4.5611.00
75_F97_M3.7901.00
70_G150_F3.3081.00
83_S86_D3.2381.00
62_V150_F3.2381.00
82_L172_G2.8811.00
69_G140_L2.7581.00
159_T167_G2.7271.00
90_L166_V2.4471.00
97_M101_L2.3671.00
62_V70_G2.0540.99
54_G88_S2.0370.99
110_S113_L1.9510.99
56_L71_A1.9310.99
91_A154_L1.8680.99
87_F91_A1.8260.98
156_Q159_T1.7770.98
131_A134_A1.7660.98
77_L133_L1.7490.98
74_L136_A1.6790.97
62_V67_A1.6750.97
32_A35_G1.6590.97
89_Q92_K1.6510.97
137_F150_F1.6430.97
106_A109_G1.5930.96
142_L150_F1.5590.96
112_G115_G1.5590.96
101_L105_P1.5570.96
56_L60_L1.5550.96
71_A152_P1.5550.96
134_A142_L1.5530.96
21_A26_A1.5480.95
113_L117_L1.5410.95
63_T102_G1.5040.95
78_A82_L1.4940.95
49_S157_Y1.4670.94
21_A24_V1.4640.94
44_A47_K1.4480.94
71_A75_F1.4370.93
73_A111_S1.4290.93
69_G137_F1.3880.92
77_L81_R1.3860.92
114_S117_L1.3830.92
110_S118_G1.3540.91
146_M157_Y1.3470.91
113_L118_G1.3010.89
74_L154_L1.2980.89
70_G160_K1.2960.89
115_G118_G1.2830.89
120_A124_G1.2610.88
78_A170_L1.2510.87
61_G64_P1.2350.87
87_F101_L1.2300.86
88_S92_K1.2230.86
96_G146_M1.2200.86
92_K98_D1.1990.85
17_G21_A1.1990.85
151_V155_T1.1870.84
108_S146_M1.1860.84
75_F94_V1.1790.84
18_D22_N1.1690.83
22_N27_A1.1650.83
76_G79_K1.1560.83
62_V159_T1.1470.82
73_A133_L1.1400.82
18_D21_A1.1350.82
24_V27_A1.1170.80
113_L116_L1.1020.80
73_A137_F1.0950.79
38_A42_A1.0740.78
45_A49_S1.0690.77
53_V99_S1.0630.77
101_L104_A1.0570.77
31_A35_G1.0540.76
28_Q31_A1.0470.76
24_V28_Q1.0370.75
137_F157_Y1.0350.75
70_G137_F1.0240.74
96_G144_P1.0160.74
69_G150_F1.0010.73
112_G118_G0.9930.72
158_V173_A0.9900.72
127_A147_V0.9870.72
146_M150_F0.9810.71
25_S29_G0.9770.71
43_A51_E0.9720.70
79_K87_F0.9690.70
70_G143_S0.9530.69
97_M103_A0.9520.69
51_E54_G0.9460.68
86_D89_Q0.9390.68
40_A43_A0.9330.67
18_D25_S0.9260.67
136_A147_V0.9200.66
170_L174_L0.9140.66
27_A31_A0.9140.66
73_A76_G0.9100.65
116_L119_S0.9090.65
26_A31_A0.8930.64
62_V142_L0.8930.64
91_A97_M0.8870.63
72_G75_F0.8860.63
25_S28_Q0.8730.62
82_L86_D0.8690.62
24_V30_A0.8580.61
42_A45_A0.8550.60
71_A94_V0.8530.60
128_G158_V0.8390.59
90_L149_K0.8370.59
162_G166_V0.8360.59
133_L145_E0.8330.58
49_S57_S0.8320.58
38_A41_A0.8250.58
56_L150_F0.8180.57
77_L80_S0.8150.57
67_A135_S0.8090.56
32_A40_A0.8080.56
95_P157_Y0.8070.56
37_A42_A0.8070.56
67_A70_G0.8040.56
131_A163_G0.8020.55
35_G38_A0.7980.55
115_G119_S0.7970.55
33_A77_L0.7960.55
171_L174_L0.7940.55
165_G168_S0.7890.54
48_A144_P0.7860.54
31_A37_A0.7820.54
86_D169_L0.7770.53
65_E73_A0.7750.53
59_Q86_D0.7650.52
41_A84_P0.7610.52
130_L144_P0.7580.51
57_S68_A0.7580.51
68_A103_A0.7480.50
76_G89_Q0.7470.50
31_A34_V0.7400.50
111_S114_S0.7400.50
123_L154_L0.7320.49
123_L126_S0.7260.48
28_Q32_A0.7240.48
51_E84_P0.7240.48
18_D23_A0.7170.47
86_D98_D0.7150.47
88_S107_L0.7130.47
110_S114_S0.7120.47
124_G148_G0.7100.47
29_G34_V0.7080.47
82_L99_S0.7060.46
137_F153_V0.7040.46
135_S147_V0.7040.46
49_S72_G0.6990.46
124_G138_S0.6980.46
52_L70_G0.6930.45
28_Q35_G0.6900.45
28_Q130_L0.6900.45
90_L164_Q0.6770.44
128_G149_K0.6760.44
121_G124_G0.6560.42
45_A48_A0.6510.41
94_V152_P0.6480.41
40_A45_A0.6410.40
98_D110_S0.6400.40
16_L21_A0.6380.40
137_F146_M0.6370.40
87_F94_V0.6350.40
150_F157_Y0.6340.40
155_T159_T0.6340.40
81_R153_V0.6290.39
107_L138_S0.6280.39
56_L149_K0.6240.39
41_A108_S0.6240.39
92_K99_S0.6220.39
75_F91_A0.6190.38
36_A41_A0.6180.38
161_S164_Q0.6130.38
22_N26_A0.6100.37
87_F167_G0.6090.37
79_K91_A0.6090.37
76_G86_D0.6080.37
48_A61_G0.6070.37
57_S70_G0.6020.37
43_A118_G0.6000.37
57_S67_A0.5990.37
30_A33_A0.5930.36
152_P155_T0.5880.36
71_A162_G0.5850.35
38_A45_A0.5840.35
53_V60_L0.5840.35
23_A125_G0.5840.35
94_V162_G0.5840.35
33_A106_A0.5820.35
56_L66_Q0.5810.35
106_A139_K0.5750.34
97_M105_P0.5620.33
48_A59_Q0.5620.33
17_G24_V0.5620.33
91_A98_D0.5590.33
50_P64_P0.5560.33
66_Q69_G0.5550.33
116_L120_A0.5550.33
28_Q33_A0.5540.33
165_G171_L0.5540.33
55_A157_Y0.5490.32
118_G157_Y0.5490.32
17_G23_A0.5480.32
26_A32_A0.5470.32
67_A165_G0.5460.32
23_A26_A0.5440.32
91_A163_G0.5410.32
82_L165_G0.5380.31
50_P93_A0.5380.31
108_S120_A0.5320.31
41_A46_A0.5300.31
53_V57_S0.5290.31
24_V34_V0.5290.31
48_A68_A0.5260.30
110_S115_G0.5240.30
150_F160_K0.5240.30
36_A39_A0.5230.30
50_P100_L0.5230.30
21_A28_Q0.5220.30
53_V116_L0.5200.30
84_P111_S0.5180.30
62_V137_F0.5160.30
155_T167_G0.5160.30
65_E68_A0.5150.29
152_P173_A0.5140.29
35_G42_A0.5130.29
37_A40_A0.5130.29
63_T135_S0.5070.29
90_L93_A0.5060.29
80_S133_L0.5030.29
74_L78_A0.5020.28
60_L140_L0.5000.28
30_A41_A0.5000.28
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1qgpA 1 0.2229 11.8 0.94 Contact Map
3ijwA 2 0.3371 5.8 0.947 Contact Map
4imiA 1 0.4171 5.3 0.948 Contact Map
2yskA 2 0.56 3.7 0.952 Contact Map
4hrrB 2 0.72 3.5 0.953 Contact Map
1jf3A 1 0.64 3.3 0.953 Contact Map
1gcvB 1 0.6629 3.1 0.954 Contact Map
3mvcA 1 0.6514 3.1 0.954 Contact Map
1ixsA 1 0.2686 2.9 0.955 Contact Map
3j21k 1 0 2.7 0.955 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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