GREMLIN Database
DUF2859 - Protein of unknown function (DUF2859)
PFAM: PF11072 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 146 (146)
Sequences: 725 (481)
Seq/√Len: 39.8
META: 0.597

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
71_F97_G7.1741.00
49_S52_L4.7801.00
51_E126_D4.0711.00
111_L120_L3.2051.00
80_R114_L3.1291.00
50_P126_D3.0711.00
9_A13_Y3.0351.00
99_V120_L2.9081.00
99_V111_L2.9031.00
75_D107_A2.6531.00
57_V136_H2.3361.00
80_R110_A2.3331.00
49_S126_D2.3201.00
105_A109_A2.2701.00
100_V125_G2.2010.99
41_E112_R2.0970.99
53_T136_H1.9810.99
2_E6_G1.9450.99
99_V108_L1.9290.99
70_F141_I1.8310.98
13_Y16_L1.6880.97
54_P78_L1.6700.96
36_A40_A1.6140.96
45_L108_L1.6090.95
75_D111_L1.5520.94
75_D80_R1.5230.94
45_L104_T1.4880.93
78_L81_A1.4770.93
134_L139_V1.4740.93
115_A120_L1.4610.92
49_S127_D1.4420.92
143_A146_I1.4190.91
52_L129_A1.4130.91
118_L124_S1.4130.91
37_S40_A1.3470.89
115_A118_L1.3190.88
108_L112_R1.3140.88
41_E45_L1.3060.87
92_E106_E1.2890.87
72_L100_V1.2720.86
70_F96_V1.2700.86
75_D102_V1.2600.85
1_V12_Y1.2540.85
71_F115_A1.2340.84
8_S18_L1.2330.84
52_L100_V1.2030.83
87_R117_G1.1880.82
110_A114_L1.1850.82
72_L124_S1.1750.81
14_E17_N1.1750.81
73_I99_V1.1590.80
7_V18_L1.1550.80
52_L134_L1.1370.79
89_R93_L1.1320.79
71_F95_A1.1300.79
1_V10_L1.1290.78
125_G129_A1.1280.78
27_Q31_P1.0670.74
47_V102_V1.0660.74
111_L128_L1.0660.74
48_R103_E1.0620.74
1_V39_A1.0520.73
57_V60_R1.0500.73
75_D101_N1.0460.73
57_V134_L1.0290.72
57_V139_V1.0280.72
7_V125_G1.0270.72
97_G115_A1.0200.71
87_R91_R0.9870.68
4_S8_S0.9760.68
91_R117_G0.9630.67
9_A16_L0.9610.66
121_L128_L0.9580.66
88_D91_R0.9550.66
47_V101_N0.9520.66
93_L118_L0.9490.65
2_E9_A0.9430.65
53_T57_V0.9380.64
13_Y41_E0.9260.63
99_V102_V0.9100.62
45_L53_T0.9050.62
4_S9_A0.8850.60
86_R89_R0.8760.59
77_P86_R0.8620.58
71_F118_L0.8620.58
107_A111_L0.8570.57
86_R99_V0.8520.57
111_L126_D0.8500.57
99_V107_A0.8340.55
47_V120_L0.8220.54
121_L127_D0.8200.54
14_E21_R0.8200.54
102_V108_L0.8130.53
31_P34_V0.8040.53
10_L14_E0.8020.52
29_P32_P0.7970.52
8_S17_N0.7970.52
42_A105_A0.7910.51
127_D142_T0.7910.51
60_R65_P0.7790.50
104_T107_A0.7690.49
35_P38_P0.7680.49
87_R115_A0.7650.49
73_I114_L0.7640.49
7_V10_L0.7630.49
102_V107_A0.7610.49
40_A47_V0.7570.48
113_A116_P0.7460.47
49_S134_L0.7320.46
18_L21_R0.7320.46
8_S69_P0.7300.46
72_L83_L0.7240.45
2_E16_L0.7230.45
120_L126_D0.7200.45
78_L110_A0.7180.45
51_E130_Q0.7140.44
26_A29_P0.7120.44
117_G132_L0.7100.44
74_G102_V0.7090.44
135_R146_I0.6920.42
49_S131_R0.6880.42
102_V117_G0.6810.41
3_D6_G0.6790.41
45_L66_G0.6750.41
41_E44_M0.6700.40
79_S82_W0.6690.40
60_R100_V0.6670.40
10_L18_L0.6630.40
122_P136_H0.6620.40
100_V129_A0.6610.40
50_P141_I0.6560.39
73_I87_R0.6550.39
7_V67_L0.6540.39
138_P141_I0.6400.38
60_R122_P0.6400.38
76_D90_L0.6390.38
9_A12_Y0.6370.38
73_I113_A0.6350.37
46_P74_G0.6310.37
85_Q121_L0.6290.37
111_L121_L0.6260.37
9_A94_G0.6220.36
54_P125_G0.6180.36
43_A111_L0.6160.36
108_L127_D0.6140.36
68_R133_G0.6140.36
54_P74_G0.6100.35
57_V108_L0.6090.35
53_T56_P0.6070.35
53_T125_G0.6070.35
53_T134_L0.6070.35
72_L119_P0.6020.35
1_V5_G0.6010.35
118_L121_L0.5990.34
72_L104_T0.5990.34
78_L106_E0.5990.34
45_L124_S0.5980.34
31_P40_A0.5960.34
10_L13_Y0.5960.34
7_V87_R0.5960.34
54_P127_D0.5950.34
54_P115_A0.5910.34
97_G120_L0.5900.34
49_S118_L0.5890.34
47_V111_L0.5860.33
1_V6_G0.5860.33
33_P36_A0.5830.33
11_P20_P0.5820.33
54_P102_V0.5770.33
5_G8_S0.5770.33
80_R143_A0.5750.32
129_A132_L0.5740.32
13_Y126_D0.5730.32
17_N23_S0.5710.32
7_V12_Y0.5710.32
68_R78_L0.5680.32
58_A100_V0.5660.32
104_T114_L0.5650.32
83_L98_L0.5640.32
74_G125_G0.5630.32
28_P32_P0.5630.32
23_S115_A0.5620.31
117_G145_G0.5570.31
33_P77_P0.5560.31
1_V9_A0.5540.31
80_R123_A0.5520.31
107_A131_R0.5520.31
55_G122_P0.5510.31
3_D8_S0.5450.30
11_P16_L0.5440.30
41_E108_L0.5420.30
40_A94_G0.5420.30
7_V16_L0.5370.30
50_P130_Q0.5360.29
62_L103_E0.5280.29
103_E106_E0.5270.29
25_P139_V0.5270.29
70_F103_E0.5220.28
109_A113_A0.5200.28
106_E110_A0.5190.28
74_G129_A0.5180.28
60_R136_H0.5170.28
8_S14_E0.5170.28
19_Q141_I0.5160.28
22_A26_A0.5160.28
1_V17_N0.5150.28
112_R122_P0.5140.28
76_D79_S0.5130.28
55_G71_F0.5120.28
31_P73_I0.5110.28
134_L140_L0.5110.28
6_G131_R0.5100.27
83_L97_G0.5050.27
65_P144_T0.5040.27
113_A135_R0.5020.27
94_G119_P0.5010.27
52_L98_L0.5010.27
45_L68_R0.5000.27
57_V123_A0.5000.27
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3lorA 3 0.7534 57 0.911 Contact Map
4ma9A 5 0.7466 53.1 0.913 Contact Map
3razA 1 0.6849 52.7 0.913 Contact Map
4gqcA 4 0.7466 51.3 0.914 Contact Map
1we0A 3 0.7466 50.9 0.914 Contact Map
3fw2A 2 0.726 48.1 0.915 Contact Map
3drnA 1 0.726 47.2 0.916 Contact Map
3zl5A 3 0.7534 47 0.916 Contact Map
2bmxA 3 0.7603 44.4 0.917 Contact Map
3eytA 4 0.7603 43.8 0.918 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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