GREMLIN Database
DUF2868 - Protein of unknown function (DUF2868)
PFAM: PF11067 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 319 (304)
Sequences: 1456 (1242)
Seq/√Len: 71.2
META: 0.769

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
36_L127_L5.0211.00
39_N126_G4.0531.00
41_G45_A3.6701.00
28_G137_A3.0741.00
96_S111_L2.8211.00
39_N127_L2.8171.00
56_A111_L2.7171.00
140_R144_A2.6231.00
89_S92_L2.5561.00
50_V115_W2.5091.00
207_L210_D2.3341.00
204_G207_L2.2751.00
202_L205_L2.2731.00
57_F96_S2.2701.00
79_P82_W2.2701.00
181_P188_A2.2301.00
31_S34_F2.1981.00
50_V119_L2.1741.00
271_L314_L2.1681.00
262_A302_P2.1481.00
269_G272_D2.1481.00
271_L313_K2.1471.00
70_H74_Q2.1171.00
73_V93_I2.1161.00
32_Q39_N2.1051.00
16_L19_R2.0981.00
256_V277_L2.0831.00
278_R281_A2.0661.00
43_L122_L2.0181.00
297_D300_T2.0031.00
48_L52_T1.9901.00
36_L39_N1.9121.00
138_L142_R1.8821.00
181_P185_P1.8451.00
25_W137_A1.8361.00
154_L157_Y1.8311.00
80_W115_W1.8141.00
42_A122_L1.8141.00
31_S35_W1.8091.00
80_W117_F1.7971.00
77_A117_F1.7741.00
28_G32_Q1.7631.00
268_R272_D1.7551.00
203_V206_E1.7511.00
284_T290_L1.7481.00
202_L206_E1.7431.00
267_D272_D1.7201.00
184_A188_A1.7001.00
54_D60_E1.6991.00
231_G234_L1.6751.00
265_P269_G1.6741.00
120_G124_V1.6490.99
181_P187_P1.6330.99
136_L139_W1.6330.99
309_D314_L1.6170.99
50_V56_A1.6070.99
91_E94_E1.5870.99
201_L206_E1.5790.99
117_F121_A1.5690.99
25_W144_A1.5680.99
60_E264_E1.5470.99
258_L274_L1.5440.99
136_L140_R1.5390.99
200_A203_V1.5050.99
57_F115_W1.4900.99
78_A82_W1.4670.99
108_A112_G1.4430.99
29_R138_L1.4430.99
60_E267_D1.4400.99
260_V269_G1.4350.99
204_G208_D1.4300.99
111_L115_W1.4280.99
241_R245_L1.4230.98
51_A63_L1.4070.98
100_R112_G1.3990.98
71_R75_A1.3870.98
35_W50_V1.3760.98
160_L164_L1.3700.98
62_T115_W1.3660.98
93_I96_S1.3480.98
182_A192_L1.3230.98
307_L311_R1.3100.97
60_E112_G1.3020.97
85_F120_G1.2900.97
201_L211_L1.2720.97
32_Q35_W1.2670.97
80_W96_S1.2580.97
289_L314_L1.2560.97
15_A19_R1.2530.97
101_L104_I1.2430.96
11_Q14_L1.2430.96
309_D313_K1.2430.96
208_D211_L1.2400.96
134_L138_L1.2380.96
303_D306_R1.2250.96
60_E92_L1.2160.96
46_L102_D1.2160.96
224_V228_V1.2140.96
78_A81_S1.2030.96
189_A195_P1.2030.96
35_W42_A1.1910.95
101_L111_L1.1900.95
29_R134_L1.1900.95
108_A111_L1.1880.95
195_P198_G1.1870.95
50_V63_L1.1810.95
183_A186_A1.1780.95
242_A245_L1.1760.95
60_E98_Y1.1740.95
232_G239_E1.1680.95
278_R282_G1.1670.95
181_P194_A1.1620.95
92_L100_R1.1540.95
56_A63_L1.1540.95
132_L136_L1.1530.95
75_A196_A1.1470.94
46_L119_L1.1450.94
84_G98_Y1.1450.94
131_L135_L1.1390.94
161_L164_L1.1350.94
286_V291_L1.1330.94
284_T287_I1.1280.94
77_A80_W1.1270.94
54_D111_L1.1270.94
26_L30_L1.1220.94
213_P239_E1.1170.94
295_G298_P1.1120.93
38_F117_F1.1070.93
256_V273_F1.1060.93
80_W263_W1.1040.93
77_A87_V1.1020.93
13_L18_G1.1000.93
182_A193_P1.0930.93
200_A206_E1.0910.93
22_L144_A1.0900.93
34_F49_L1.0830.93
49_L53_R1.0770.92
26_L29_R1.0760.92
159_R163_R1.0750.92
157_Y160_L1.0740.92
101_L112_G1.0710.92
181_P193_P1.0670.92
60_E99_F1.0620.92
14_L18_G1.0600.92
32_Q80_W1.0530.91
37_A40_L1.0410.91
312_R316_A1.0390.91
190_A195_P1.0340.91
26_L141_L1.0340.91
83_L97_R1.0270.90
179_P182_A1.0240.90
235_D238_R1.0210.90
56_A60_E1.0200.90
200_A207_L1.0200.90
270_T314_L1.0200.90
66_A94_E1.0150.90
259_L274_L1.0110.90
138_L141_L1.0050.89
69_F133_L1.0000.89
95_A100_R0.9980.89
206_E211_L0.9940.89
243_A247_Q0.9940.89
33_L134_L0.9930.89
117_F262_A0.9890.89
181_P190_A0.9820.88
187_P195_P0.9820.88
52_T73_V0.9790.88
219_G258_L0.9790.88
182_A191_A0.9690.88
163_R278_R0.9660.87
268_R313_K0.9640.87
13_L17_L0.9640.87
54_D115_W0.9640.87
202_L210_D0.9630.87
191_A194_A0.9630.87
54_D96_S0.9590.87
24_R31_S0.9570.87
231_G235_D0.9530.87
215_A219_G0.9520.87
244_L249_A0.9500.87
61_T259_L0.9490.87
108_A116_P0.9460.86
37_A41_G0.9350.86
115_W263_W0.9350.86
93_I106_L0.9330.86
257_L275_A0.9310.85
63_L108_A0.9300.85
56_A115_W0.9280.85
88_P96_S0.9220.85
47_L50_V0.9210.85
196_A199_P0.9210.85
38_F42_A0.9150.84
201_L207_L0.9140.84
231_G273_F0.9120.84
97_R100_R0.9090.84
60_E100_R0.9090.84
50_V55_Y0.9080.84
246_E250_A0.9060.84
77_A113_A0.9040.84
306_R314_L0.9030.84
35_W206_E0.8970.83
11_Q15_A0.8960.83
50_V57_F0.8880.83
201_L205_L0.8810.82
75_A136_L0.8780.82
111_L264_E0.8770.82
261_E264_E0.8760.82
205_L208_D0.8750.82
57_F62_T0.8740.82
32_Q115_W0.8740.82
96_S100_R0.8710.81
25_W126_G0.8700.81
266_P269_G0.8660.81
46_L50_V0.8660.81
38_F115_W0.8650.81
58_G267_D0.8630.81
224_V258_L0.8570.80
40_L44_A0.8560.80
54_D117_F0.8540.80
270_T313_K0.8540.80
139_W143_R0.8510.80
281_A287_I0.8510.80
93_I114_W0.8500.80
53_R60_E0.8480.80
193_P196_A0.8460.79
79_P117_F0.8450.79
185_P189_A0.8420.79
11_Q18_G0.8350.79
72_L76_L0.8350.79
183_A195_P0.8340.79
50_V80_W0.8270.78
236_L239_E0.8250.78
41_G121_A0.8220.78
107_A110_A0.8200.77
94_E97_R0.8160.77
119_L269_G0.8140.77
129_P269_G0.8140.77
56_A101_L0.8120.77
181_P192_L0.8120.77
314_L317_L0.8120.77
167_P171_T0.8110.77
190_A199_P0.8100.76
31_S61_T0.8050.76
178_A181_P0.7990.75
57_F271_L0.7950.75
25_W140_R0.7880.74
78_A216_L0.7860.74
81_S95_A0.7850.74
178_A188_A0.7840.74
299_G302_P0.7830.74
202_L259_L0.7830.74
148_L164_L0.7810.74
133_L160_L0.7800.74
185_P191_A0.7780.74
100_R264_E0.7770.73
84_G115_W0.7740.73
258_L270_T0.7730.73
313_K317_L0.7730.73
43_L62_T0.7720.73
158_R161_L0.7720.73
92_L96_S0.7710.73
192_L195_P0.7680.73
14_L19_R0.7680.73
49_L126_G0.7610.72
302_P309_D0.7570.71
12_A18_G0.7560.71
222_V225_A0.7530.71
213_P220_L0.7530.71
119_L126_G0.7510.71
140_R143_R0.7500.71
180_A186_A0.7490.71
220_L224_V0.7480.71
132_L308_A0.7480.71
38_F313_K0.7480.71
11_Q17_L0.7470.70
54_D80_W0.7470.70
58_G69_F0.7440.70
47_L119_L0.7430.70
180_A187_P0.7430.70
15_A18_G0.7420.70
57_F126_G0.7310.69
100_R111_L0.7290.69
304_A307_L0.7290.69
13_L19_R0.7270.68
271_L277_L0.7260.68
69_F98_Y0.7260.68
277_L313_K0.7240.68
83_L124_V0.7210.68
32_Q134_L0.7180.67
31_S144_A0.7180.67
92_L113_A0.7170.67
135_L193_P0.7170.67
71_R209_D0.7150.67
54_D100_R0.7120.67
36_L131_L0.7110.67
227_V232_G0.7110.67
96_S115_W0.7080.66
219_G222_V0.7050.66
59_W62_T0.7040.66
38_F263_W0.7030.66
32_Q157_Y0.7030.66
243_A246_E0.7010.66
83_L204_G0.7010.66
192_L199_P0.7000.65
117_F265_P0.7000.65
240_Q243_A0.7000.65
243_A248_L0.6980.65
203_V212_P0.6940.65
77_A242_A0.6930.65
98_Y101_L0.6930.65
180_A184_A0.6900.64
57_F125_Y0.6880.64
118_L125_Y0.6860.64
73_V206_E0.6850.64
45_A138_L0.6830.64
200_A204_G0.6790.63
226_E237_D0.6780.63
100_R104_I0.6780.63
270_T274_L0.6770.63
43_L88_P0.6750.63
80_W267_D0.6700.62
68_T71_R0.6690.62
12_A17_L0.6680.62
203_V207_L0.6680.62
117_F261_E0.6650.62
179_P274_L0.6650.62
181_P196_A0.6640.61
111_L267_D0.6640.61
79_P125_Y0.6640.61
93_I250_A0.6630.61
148_L156_G0.6620.61
56_A263_W0.6600.61
309_D316_A0.6590.61
60_E115_W0.6590.61
66_A97_R0.6570.61
101_L108_A0.6550.60
182_A197_G0.6500.60
40_L214_P0.6490.60
21_R61_T0.6460.59
140_R147_R0.6450.59
308_A311_R0.6450.59
253_P258_L0.6420.59
115_W125_Y0.6380.58
215_A218_A0.6370.58
83_L217_P0.6310.57
95_A101_L0.6310.57
228_V233_R0.6290.57
70_H90_L0.6290.57
92_L101_L0.6270.57
74_Q109_A0.6270.57
56_A264_E0.6230.57
12_A16_L0.6180.56
192_L197_G0.6120.55
55_Y97_R0.6100.55
218_A256_V0.6090.55
185_P192_L0.6090.55
60_E261_E0.6070.55
200_A205_L0.6070.55
112_G116_P0.6050.54
150_L154_L0.6040.54
286_V311_R0.6040.54
304_A318_G0.6040.54
93_I113_A0.6020.54
60_E111_L0.6010.54
287_I291_L0.5960.53
220_L223_R0.5960.53
183_A194_A0.5950.53
42_A162_R0.5900.53
87_V109_A0.5880.52
35_W73_V0.5880.52
72_L136_L0.5880.52
98_Y112_G0.5870.52
177_A180_A0.5870.52
117_F263_W0.5830.52
52_T126_G0.5830.52
61_T241_R0.5810.51
121_A246_E0.5800.51
188_A193_P0.5770.51
65_S131_L0.5770.51
140_R289_L0.5760.51
54_D263_W0.5750.51
180_A193_P0.5730.50
217_P259_L0.5710.50
276_E279_R0.5710.50
161_L165_Q0.5700.50
101_L110_A0.5700.50
51_A61_T0.5690.50
32_Q117_F0.5680.50
240_Q244_L0.5660.50
22_L47_L0.5660.50
288_L291_L0.5660.50
128_L174_V0.5650.49
151_D157_Y0.5650.49
202_L207_L0.5640.49
32_Q126_G0.5640.49
225_A232_G0.5640.49
22_L119_L0.5620.49
29_R141_L0.5620.49
21_R24_R0.5590.49
27_L30_L0.5590.49
29_R274_L0.5580.49
80_W125_Y0.5580.49
68_T72_L0.5570.48
38_F56_A0.5560.48
43_L127_L0.5550.48
286_V290_L0.5520.48
60_E108_A0.5520.48
47_L57_F0.5510.48
99_F261_E0.5510.48
177_A190_A0.5500.48
132_L301_A0.5490.48
259_L287_I0.5480.47
135_L187_P0.5470.47
34_F120_G0.5460.47
184_A195_P0.5450.47
22_L60_E0.5450.47
109_A283_A0.5410.47
83_L308_A0.5380.46
106_L110_A0.5370.46
100_R110_A0.5350.46
96_S264_E0.5350.46
60_E101_L0.5350.46
263_W291_L0.5340.46
69_F269_G0.5340.46
25_W228_V0.5300.45
80_W261_E0.5300.45
242_A246_E0.5290.45
77_A263_W0.5280.45
43_L119_L0.5250.45
86_A116_P0.5240.44
260_V264_E0.5240.44
41_G168_S0.5230.44
262_A265_P0.5220.44
92_L264_E0.5220.44
150_L157_Y0.5220.44
177_A187_P0.5190.44
179_P191_A0.5180.44
66_A70_H0.5180.44
67_E71_R0.5170.44
226_E247_Q0.5160.44
265_P313_K0.5140.43
141_L230_D0.5140.43
26_L37_A0.5130.43
76_L201_L0.5090.43
53_R69_F0.5080.43
181_P189_A0.5060.42
261_E265_P0.5060.42
278_R284_T0.5050.42
180_A183_A0.5050.42
235_D239_E0.5050.42
109_A196_A0.5040.42
90_L94_E0.5020.42
126_G148_L0.5020.42
199_P237_D0.5000.42
26_L61_T0.5000.42
185_P188_A0.5000.42
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1sflA 2 0.2821 9.1 0.962 Contact Map
3hzhA 1 0.3824 7.2 0.964 Contact Map
1f6kA 3 0.3918 7.1 0.964 Contact Map
1xkyA 3 0.4702 7.1 0.964 Contact Map
2plnA 2 0.3354 7.1 0.964 Contact Map
3daqA 2 0.3887 6.9 0.964 Contact Map
2ehhA 3 0.3824 5.9 0.965 Contact Map
3b4uA 2 0.3856 5.9 0.965 Contact Map
4xkyA 3 0.3918 5.8 0.965 Contact Map
2pcqA 3 0.3605 5.6 0.965 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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