GREMLIN Database
DUF2867 - Protein of unknown function (DUF2867)
PFAM: PF11066 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 144 (132)
Sequences: 13638 (8185)
Seq/√Len: 712.4
META: 0.872

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
12_A112_R3.1631.00
14_P112_R2.6401.00
10_V114_R2.5921.00
14_P110_G2.4871.00
133_I136_F2.3201.00
14_P105_V2.2841.00
40_Y143_G2.2721.00
95_D120_R2.2371.00
23_T26_R2.1301.00
20_P23_T2.1131.00
10_V116_T2.0571.00
103_S114_R1.9911.00
138_R142_R1.9541.00
66_D69_E1.9491.00
12_A114_R1.9171.00
134_L138_R1.9031.00
105_V112_R1.8911.00
25_F84_L1.8481.00
25_F29_E1.8431.00
72_V83_A1.8281.00
30_R68_D1.6831.00
131_Y134_L1.6621.00
102_V111_T1.6471.00
32_I39_Y1.6421.00
22_E87_D1.6391.00
103_S112_R1.6331.00
104_P111_T1.6161.00
26_R29_E1.5951.00
80_R88_E1.5901.00
24_V27_V1.5141.00
48_R51_G1.5131.00
40_Y139_L1.5101.00
30_R36_P1.4331.00
70_L76_L1.4321.00
121_P130_W1.4091.00
100_F113_L1.3991.00
16_P19_A1.3781.00
133_I140_I1.3751.00
101_R114_R1.3681.00
65_R69_E1.3361.00
105_V110_G1.3331.00
25_F28_I1.3291.00
72_V84_L1.3201.00
11_R142_R1.3071.00
29_E84_L1.2661.00
27_V30_R1.2561.00
23_T27_V1.2461.00
136_F140_I1.2421.00
127_R131_Y1.2381.00
6_R120_R1.2371.00
28_I102_V1.2191.00
48_R52_G1.2071.00
47_D52_G1.1731.00
106_G109_G1.1541.00
16_P20_P1.1071.00
65_R71_R1.0881.00
88_E103_S1.0841.00
24_V113_L1.0501.00
15_V24_V1.0401.00
27_V36_P1.0391.00
100_F115_Q1.0371.00
106_G110_G1.0301.00
29_E68_D1.0261.00
104_P110_G1.0201.00
101_R116_T1.0181.00
11_R138_R1.0051.00
8_V118_L1.0001.00
39_Y43_W0.9961.00
124_L128_L0.9901.00
6_R121_P0.9871.00
42_L136_F0.9811.00
47_D58_G0.9801.00
47_D57_R0.9771.00
36_P39_Y0.9761.00
15_V113_L0.9641.00
47_D51_G0.9641.00
24_V28_I0.9621.00
50_V55_L0.9571.00
67_P71_R0.9511.00
82_E97_W0.9501.00
21_P104_P0.9491.00
94_G101_R0.9401.00
70_L73_G0.9381.00
7_L130_W0.9281.00
91_L96_A0.9041.00
4_G120_R0.9041.00
75_A80_R0.8941.00
23_T28_I0.8941.00
84_L89_M0.8851.00
26_R68_D0.8721.00
29_E69_E0.8631.00
70_L84_L0.8571.00
130_W134_L0.8501.00
50_V53_V0.8441.00
35_E67_P0.8401.00
77_D81_V0.8391.00
125_L128_L0.8371.00
21_P25_F0.8321.00
99_E118_L0.8281.00
70_L74_D0.8241.00
94_G99_E0.8121.00
7_L133_I0.8041.00
71_R74_D0.8031.00
47_D50_V0.8011.00
124_L127_R0.7971.00
65_R74_D0.7961.00
15_V19_A0.7891.00
35_E39_Y0.7861.00
91_L119_F0.7801.00
49_L52_G0.7751.00
132_A135_P0.7721.00
24_V29_E0.7711.00
51_G59_R0.7661.00
9_D133_I0.7621.00
44_R48_R0.7591.00
16_P110_G0.7531.00
92_P119_F0.7521.00
21_P24_V0.7501.00
22_E26_R0.7491.00
43_W47_D0.7421.00
15_V111_T0.7411.00
100_F117_A0.7401.00
37_G40_Y0.7321.00
97_W118_L0.7301.00
69_E74_D0.7281.00
20_P24_V0.7221.00
99_E122_R0.7091.00
24_V111_T0.7081.00
41_A139_L0.6971.00
27_V39_Y0.6881.00
75_A78_F0.6861.00
95_D118_L0.6861.00
17_G20_P0.6831.00
96_A117_A0.6811.00
46_R129_Y0.6751.00
105_V108_G0.6731.00
7_L121_P0.6731.00
82_E92_P0.6721.00
119_F130_W0.6651.00
47_D59_R0.6601.00
19_A23_T0.6581.00
42_L133_I0.6581.00
36_P68_D0.6541.00
78_F91_L0.6531.00
94_G122_R0.6531.00
26_R30_R0.6511.00
76_L81_V0.6451.00
54_G58_G0.6401.00
96_A130_W0.6401.00
133_I142_R0.6391.00
34_G37_G0.6371.00
95_D122_R0.6311.00
117_A137_H0.6251.00
65_R70_L0.6231.00
97_W115_Q0.6211.00
125_L132_A0.6201.00
88_E105_V0.6091.00
123_G126_G0.6071.00
133_I138_R0.6031.00
104_P113_L0.6001.00
11_R117_A0.5991.00
19_A27_V0.5991.00
83_A86_P0.5991.00
32_I89_M0.5951.00
40_Y140_I0.5901.00
7_L131_Y0.5871.00
17_G111_T0.5841.00
106_G111_T0.5841.00
135_P139_L0.5831.00
76_L80_R0.5801.00
50_V95_D0.5731.00
49_L53_V0.5721.00
69_E72_V0.5711.00
58_G78_F0.5661.00
97_W127_R0.5611.00
12_A16_P0.5591.00
115_Q141_F0.5551.00
37_G41_A0.5521.00
44_R55_L0.5491.00
66_D71_R0.5471.00
7_L127_R0.5441.00
14_P111_T0.5381.00
104_P109_G0.5361.00
47_D56_R0.5331.00
38_W140_I0.5301.00
95_D98_L0.5281.00
94_G100_F0.5261.00
10_V103_S0.5211.00
90_K99_E0.5181.00
51_G57_R0.5121.00
58_G75_A0.5111.00
54_G96_A0.5111.00
68_D72_V0.5111.00
34_G43_W0.5080.99
66_D70_L0.5070.99
56_R88_E0.5030.99
29_E86_P0.5020.99
25_F87_D0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2pcsA 1 0.8611 14.8 0.92 Contact Map
2ns9A 2 0.9097 8.3 0.929 Contact Map
3ggnA 2 0.7778 7.5 0.93 Contact Map
3ossC 1 0.4375 5.7 0.934 Contact Map
3p9vA 2 0.9028 5.5 0.934 Contact Map
1t17A 1 0.8889 4.6 0.937 Contact Map
1vjkA 1 0.5069 4.5 0.937 Contact Map
2m19A 1 0.5556 3.5 0.94 Contact Map
2qjlA 1 0.5694 3.1 0.942 Contact Map
3f59A 1 0.3403 2.7 0.943 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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