GREMLIN Database
DUF2865 - Protein of unknown function (DUF2865)
PFAM: PF11064 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 115 (111)
Sequences: 3527 (1677)
Seq/√Len: 159.2
META: 0.92

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
73_R77_E4.4681.00
10_C82_C4.4111.00
15_F36_L3.5491.00
9_T68_L2.9411.00
64_P67_D2.8091.00
5_V54_I2.5541.00
54_I57_A2.5501.00
37_C84_C2.5311.00
73_R79_V2.4331.00
48_R52_S2.3961.00
43_K61_D2.2121.00
31_Q34_Q2.0381.00
43_K59_S1.8341.00
63_Q67_D1.7831.00
70_N73_R1.6461.00
5_V47_Y1.5831.00
55_D72_F1.5451.00
47_Y54_I1.4611.00
5_V57_A1.4531.00
85_N88_G1.4301.00
46_Y60_L1.4051.00
53_D56_Q1.3861.00
30_A34_Q1.3841.00
72_F75_R1.3821.00
66_S72_F1.3701.00
73_R76_K1.3361.00
101_D104_L1.3261.00
45_Y59_S1.3111.00
25_R28_S1.3001.00
17_I44_L1.2911.00
14_Y75_R1.2811.00
4_T29_D1.2681.00
88_G91_W1.2631.00
13_Y74_Y1.2211.00
104_L107_G1.2061.00
97_D101_D1.2041.00
18_S29_D1.1881.00
2_Y26_F1.1621.00
9_T43_K1.1571.00
21_T25_R1.1481.00
9_T41_E1.1281.00
14_Y54_I1.1211.00
23_P26_F1.1191.00
3_R19_F1.1131.00
55_D66_S1.1101.00
45_Y70_N1.1091.00
91_W95_L1.1081.00
38_P42_T1.0690.99
83_T86_G1.0640.99
92_G96_V1.0570.99
96_V99_E1.0570.99
5_V14_Y1.0490.99
4_T26_F1.0440.99
92_G95_L1.0370.99
29_D44_L1.0360.99
89_Q93_L1.0010.99
104_L110_V0.9970.99
96_V100_D0.9890.99
101_D105_R0.9850.99
86_G89_Q0.9840.99
32_T36_L0.9760.99
59_S63_Q0.9630.99
19_F50_P0.9550.99
98_A101_D0.9480.99
26_F44_L0.9440.99
100_D109_I0.9380.98
47_Y51_G0.9340.98
103_T107_G0.9250.98
8_R13_Y0.9020.98
91_W94_A0.9020.98
83_T87_K0.9010.98
34_Q42_T0.8820.98
97_D100_D0.8770.98
39_A88_G0.8760.98
106_P112_T0.8720.97
26_F29_D0.8710.97
21_T26_F0.8670.97
52_S56_Q0.8530.97
95_L98_A0.8390.97
26_F30_A0.8390.97
22_T25_R0.8350.97
56_Q66_S0.8340.97
71_A74_Y0.8290.97
57_A72_F0.8050.96
2_Y23_P0.8030.96
46_Y58_V0.8000.96
95_L99_E0.7960.96
103_T108_D0.7810.95
78_L91_W0.7790.95
60_L63_Q0.7790.95
18_S21_T0.7780.95
89_Q95_L0.7460.94
103_T110_V0.7400.94
21_T29_D0.7350.93
32_T35_A0.7130.92
40_A83_T0.7010.92
40_A82_C0.6990.92
34_Q41_E0.6970.92
106_P113_E0.6960.91
43_K46_Y0.6770.90
16_P74_Y0.6740.90
66_S69_P0.6700.90
54_I72_F0.6680.90
43_K63_Q0.6640.89
104_L108_D0.6600.89
94_A97_D0.6510.89
45_Y68_L0.6500.88
91_W98_A0.6480.88
8_R11_D0.6450.88
20_S29_D0.6360.87
102_P106_P0.6360.87
56_Q77_E0.6320.87
93_L96_V0.6300.87
38_P83_T0.6270.87
3_R47_Y0.6250.86
85_N89_Q0.6240.86
41_E69_P0.6230.86
3_R17_I0.6210.86
38_P89_Q0.6170.86
4_T18_S0.6090.85
10_C40_A0.6070.85
33_C37_C0.6030.84
4_T44_L0.6010.84
101_D106_P0.6000.84
35_A92_G0.6000.84
7_V11_D0.5930.83
109_I113_E0.5910.83
42_T82_C0.5910.83
24_S48_R0.5900.83
37_C68_L0.5880.83
42_T47_Y0.5840.83
29_D32_T0.5820.82
98_A102_P0.5790.82
39_A86_G0.5780.82
91_W99_E0.5750.82
31_Q35_A0.5750.82
3_R29_D0.5720.81
101_D110_V0.5660.81
6_C11_D0.5650.80
76_K85_N0.5630.80
8_R12_G0.5590.80
102_P105_R0.5570.80
47_Y52_S0.5550.79
39_A79_V0.5540.79
66_S87_K0.5540.79
57_A65_Y0.5530.79
94_A98_A0.5480.78
101_D107_G0.5470.78
30_A44_L0.5460.78
30_A41_E0.5460.78
105_R108_D0.5410.78
79_V83_T0.5350.77
7_V12_G0.5310.76
6_C12_G0.5290.76
85_N91_W0.5280.76
103_T106_P0.5260.76
68_L84_C0.5220.75
4_T17_I0.5220.75
61_D66_S0.5160.74
19_F29_D0.5140.74
105_R109_I0.5110.73
39_A42_T0.5080.73
31_Q43_K0.5070.73
21_T44_L0.5020.72
24_S62_G0.5010.72
19_F47_Y0.5000.72
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2pbiA 1 0.8435 10.5 0.937 Contact Map
3wvqA 2 0.3652 4.1 0.948 Contact Map
2gmhA 1 0.4609 4 0.948 Contact Map
1j3gA 1 0.4522 3.7 0.949 Contact Map
1bgkA 1 0.113 2.4 0.953 Contact Map
4didB 1 0.6609 2.1 0.955 Contact Map
4gdiA 4 0.3304 1.6 0.958 Contact Map
2eknA 5 0.4261 1.5 0.959 Contact Map
2ohdA 5 0.4261 1.5 0.959 Contact Map
1byyA 1 0.0783 1.4 0.959 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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