GREMLIN Database
DUF2862 - Protein of unknown function (DUF2862)
PFAM: PF11061 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 61 (60)
Sequences: 772 (377)
Seq/√Len: 48.6
META: 0.829

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
36_T40_G3.5601.00
35_M39_K3.2041.00
21_A49_D2.5641.00
31_S46_E2.4691.00
35_M41_I2.1601.00
4_K29_T1.9170.99
2_G6_K1.8130.99
10_V14_L1.8090.99
9_R58_D1.6240.98
28_G53_T1.4870.96
54_W59_E1.4150.95
36_T41_I1.3720.94
37_D42_G1.2900.92
29_T46_E1.2880.92
5_V30_I1.2690.91
14_L18_L1.2670.91
31_S45_V1.2670.91
12_D33_F1.2430.90
28_G45_V1.2300.90
17_E26_P1.1520.86
20_D23_G1.0930.83
22_L28_G1.0890.83
46_E50_G1.0750.82
22_L26_P1.0730.82
44_V52_E1.0480.81
7_L45_V1.0420.80
17_E21_A1.0410.80
20_D44_V1.0190.79
56_F59_E1.0130.78
25_S48_S1.0120.78
2_G5_V1.0050.78
10_V15_P0.9950.77
21_A51_S0.9710.75
30_I40_G0.9580.74
30_I41_I0.9480.73
33_F43_V0.9470.73
5_V21_A0.9460.73
30_I36_T0.9370.73
20_D43_V0.9230.71
35_M53_T0.9210.71
38_G42_G0.9160.71
21_A45_V0.9120.70
20_D24_K0.9020.70
32_D36_T0.8610.66
23_G47_L0.8350.64
48_S51_S0.8300.63
5_V9_R0.8250.63
8_E16_K0.8240.63
3_Q6_K0.8240.63
43_V57_E0.8210.62
23_G26_P0.8130.62
6_K15_P0.8070.61
15_P22_L0.8050.61
10_V18_L0.8000.60
1_I6_K0.7610.56
43_V50_G0.7590.56
6_K44_V0.7520.56
16_K20_D0.7500.55
36_T51_S0.7480.55
19_I45_V0.7270.53
3_Q36_T0.7190.52
15_P23_G0.7110.51
24_K58_D0.7080.51
21_A48_S0.6930.50
36_T43_V0.6850.49
35_M42_G0.6730.48
43_V60_I0.6650.47
1_I8_E0.6540.46
7_L11_R0.6430.45
13_R22_L0.6420.44
24_K51_S0.6380.44
1_I24_K0.6340.44
19_I29_T0.6210.42
19_I60_I0.6180.42
36_T60_I0.6180.42
9_R22_L0.6110.41
45_V48_S0.6060.41
11_R53_T0.5930.40
45_V53_T0.5860.39
12_D42_G0.5790.38
4_K16_K0.5770.38
6_K19_I0.5700.37
12_D47_L0.5670.37
9_R33_F0.5620.37
14_L57_E0.5280.34
14_L19_I0.5240.33
37_D55_F0.5230.33
19_I24_K0.5190.33
49_D53_T0.5070.32
20_D49_D0.5000.31
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ju0A 1 0.7213 45.9 0.856 Contact Map
4tseA 2 0.8852 45.8 0.856 Contact Map
3jtzA 2 0.7213 39.5 0.862 Contact Map
3db7A 2 0.9672 15.8 0.886 Contact Map
4qoaA 2 0.9508 12.8 0.89 Contact Map
4qqbX 1 0.623 12.2 0.892 Contact Map
4dsdA 1 0.9344 10.8 0.894 Contact Map
3lxrF 1 0.3934 10.8 0.894 Contact Map
4k61A 1 0.7869 10.3 0.895 Contact Map
1fx7A 4 0.9672 9.5 0.897 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0047 seconds.