GREMLIN Database
DUF2750 - Protein of unknown function (DUF2750)
PFAM: PF11042 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 102 (100)
Sequences: 3265 (2593)
Seq/√Len: 259.3
META: 0.782

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
13_E59_E3.5631.00
16_G23_W3.3731.00
41_K45_E3.2701.00
15_W57_P2.6691.00
37_F65_F2.4041.00
74_E96_E2.4021.00
18_R58_V2.3251.00
39_S83_N2.1671.00
24_A55_Y2.1391.00
14_V65_F2.0171.00
3_Y43_F1.8681.00
40_S43_F1.8641.00
4_F8_V1.8261.00
17_L48_A1.8091.00
25_L33_D1.6211.00
61_S64_E1.5931.00
7_E40_S1.5571.00
2_E6_K1.5201.00
43_F83_N1.4971.00
69_W72_G1.4241.00
28_D32_E1.3781.00
72_G76_D1.3291.00
66_L99_L1.3171.00
41_K59_E1.2951.00
48_A57_P1.2401.00
97_E101_D1.2111.00
47_C52_W1.2041.00
37_F80_V1.1961.00
14_V70_L1.1861.00
81_G84_W1.1851.00
34_V81_G1.1831.00
3_Y83_N1.1791.00
45_E57_P1.1511.00
68_R72_G1.1441.00
69_W76_D1.1291.00
7_E83_N1.1201.00
7_E43_F1.1191.00
62_L66_L1.1111.00
64_E68_R1.1071.00
4_F37_F1.1051.00
85_N88_L1.0981.00
85_N89_E1.0921.00
63_D67_E1.0841.00
7_E11_T1.0801.00
4_F98_L1.0791.00
4_F82_V1.0711.00
44_A48_A1.0661.00
26_S29_D1.0571.00
39_S43_F1.0461.00
19_D22_G1.0351.00
65_F70_L1.0331.00
9_A62_L1.0321.00
74_E94_E1.0241.00
23_W58_V1.0151.00
3_Y6_K0.9981.00
33_D78_L0.9971.00
42_E45_E0.9521.00
5_I98_L0.9381.00
70_L99_L0.9301.00
80_V98_L0.9261.00
16_G60_I0.9201.00
97_E100_E0.9091.00
3_Y7_E0.9061.00
69_W73_L0.9031.00
18_R23_W0.8971.00
44_A57_P0.8951.00
81_G90_G0.8931.00
42_E46_A0.8931.00
7_E10_D0.8901.00
24_A52_W0.8681.00
73_L78_L0.8520.99
13_E41_K0.8520.99
50_G53_A0.8500.99
29_D32_E0.8460.99
17_L44_A0.8330.99
32_E79_L0.8250.99
60_I69_W0.8240.99
82_V98_L0.8130.99
7_E39_S0.8060.99
3_Y39_S0.8040.99
84_W92_E0.7910.99
8_V98_L0.7910.99
96_E100_E0.7900.99
11_T40_S0.7890.99
12_E63_D0.7830.99
94_E97_E0.7820.99
73_L80_V0.7810.99
6_K9_A0.7740.99
16_G35_L0.7710.99
70_L74_E0.7700.99
35_L73_L0.7630.99
19_D55_Y0.7620.99
70_L95_P0.7540.99
16_G37_F0.7400.99
79_L94_E0.7360.99
80_V95_P0.7300.98
82_V101_D0.7280.98
36_P84_W0.7270.98
52_W55_Y0.7200.98
81_G92_E0.7170.98
32_E94_E0.7080.98
48_A54_G0.7030.98
34_V92_E0.7020.98
65_F69_W0.7000.98
4_F14_V0.6920.98
8_V62_L0.6890.98
20_E56_E0.6840.98
17_L52_W0.6820.98
45_E48_A0.6800.98
95_P98_L0.6770.97
18_R56_E0.6680.97
46_A86_P0.6600.97
88_L92_E0.6500.97
73_L95_P0.6480.97
93_V98_L0.6430.97
15_W41_K0.6420.96
32_E77_G0.6410.96
71_P99_L0.6320.96
34_V84_W0.6320.96
61_S77_G0.6140.95
93_V101_D0.6090.95
26_S84_W0.6080.95
6_K11_T0.6060.95
3_Y10_D0.6050.95
13_E61_S0.6050.95
2_E101_D0.6020.95
5_I101_D0.6010.95
43_F46_A0.5990.95
3_Y42_E0.5970.95
26_S81_G0.5920.95
89_E92_E0.5920.95
37_F70_L0.5870.94
26_S33_D0.5700.93
65_F98_L0.5590.93
30_E87_D0.5550.92
25_L55_Y0.5540.92
85_N90_G0.5520.92
94_E100_E0.5510.92
26_S92_E0.5510.92
96_E99_L0.5470.92
49_K52_W0.5440.92
27_E33_D0.5390.91
66_L70_L0.5370.91
16_G24_A0.5280.90
47_C65_F0.5120.89
41_K57_P0.5100.89
12_E62_L0.5080.89
6_K10_D0.5020.88
35_L69_W0.5010.88
37_F84_W0.5000.88
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4e6zA 1 0.8725 16 0.886 Contact Map
1wspA 3 0.3922 11.1 0.894 Contact Map
1hksA 1 0.4314 10.5 0.895 Contact Map
4ev1A 2 0.9608 9.8 0.896 Contact Map
3pz7A 1 0.3824 9 0.898 Contact Map
3htsB 2 0.4216 7.9 0.9 Contact Map
3syjA 2 0.1667 7.2 0.902 Contact Map
1vjlA 2 0.8725 7.2 0.902 Contact Map
4muqA 1 0.3824 5.8 0.907 Contact Map
2lduA 1 0.5588 5.6 0.907 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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