GREMLIN Database
DUF2612 - Protein of unknown function (DUF2612)
PFAM: PF11041 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 183 (180)
Sequences: 1523 (1263)
Seq/√Len: 94.2
META: 0.794

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
57_V110_I5.4031.00
74_F83_F4.8631.00
59_V110_I3.2011.00
102_S105_A3.1221.00
54_G106_Y3.1121.00
47_G103_D3.0511.00
48_F52_I2.7521.00
145_N149_T2.6851.00
43_D111_K2.6521.00
42_L110_I2.4811.00
120_D125_S2.4431.00
62_V100_S2.3961.00
5_I16_V2.3401.00
144_D147_D2.3051.00
81_L86_G2.2011.00
75_D84_D2.1731.00
6_I9_Y2.1671.00
42_L111_K2.1481.00
53_W57_V2.1271.00
17_A21_A2.1251.00
57_V117_N2.1121.00
61_R103_D1.9961.00
83_F88_F1.9721.00
145_N151_T1.9571.00
60_S106_Y1.9101.00
46_V49_Q1.8711.00
160_T163_E1.8361.00
39_V48_F1.8121.00
74_F88_F1.7341.00
82_G85_Q1.7341.00
35_F39_V1.7211.00
57_V114_I1.6951.00
113_K117_N1.6891.00
51_D61_R1.6691.00
42_L57_V1.6391.00
51_D103_D1.5811.00
54_G61_R1.5811.00
146_G149_T1.5471.00
21_A25_P1.5451.00
30_Q34_D1.5231.00
37_D41_D1.4601.00
144_D148_M1.4411.00
61_R106_Y1.4140.99
77_A80_A1.4130.99
2_L20_E1.4060.99
122_T125_S1.3480.99
101_L109_L1.3460.99
137_G163_E1.3430.99
151_T182_N1.3320.99
148_M179_V1.3100.99
115_A129_I1.2980.99
51_D106_Y1.2930.99
54_G103_D1.2890.99
9_Y12_S1.2650.99
52_I56_I1.2640.99
157_F163_E1.2600.99
159_L163_E1.2530.99
171_D175_R1.2280.98
32_L40_F1.2120.98
20_E24_Q1.1900.98
22_L26_L1.1720.98
35_F40_F1.1570.98
70_V81_L1.1560.98
12_S15_L1.1550.98
51_D54_G1.1500.98
103_D106_Y1.1450.98
128_A132_F1.1390.97
24_Q28_P1.1250.97
47_G51_D1.1180.97
106_Y110_I1.1170.97
125_S128_A1.1130.97
112_A133_L1.1080.97
72_F88_F1.1050.97
33_L36_L1.0990.97
5_I19_I1.0970.97
15_L18_L1.0840.97
9_Y15_L1.0810.97
59_V109_L1.0630.96
47_G106_Y1.0590.96
165_A169_Q1.0330.95
108_L163_E1.0290.95
16_V20_E1.0120.95
45_A50_L1.0100.95
7_S10_A1.0040.95
38_D46_V0.9980.95
18_L22_L0.9900.94
89_Y95_T0.9840.94
119_S125_S0.9780.94
104_D107_R0.9750.94
42_L46_V0.9690.94
34_D38_D0.9670.94
114_I117_N0.9660.94
6_I12_S0.9650.94
41_D44_T0.9630.93
18_L25_P0.9620.93
27_D31_D0.9520.93
148_M176_P0.9450.93
6_I15_L0.9430.93
38_D42_L0.9410.93
144_D175_R0.9350.92
127_N130_L0.9300.92
40_F49_Q0.9240.92
78_G85_Q0.9200.92
155_F159_L0.9200.92
28_P31_D0.9140.92
139_R156_G0.9090.91
36_L41_D0.9000.91
2_L10_A0.8990.91
58_G117_N0.8940.91
113_K116_A0.8910.90
138_G141_Y0.8910.90
115_A133_L0.8790.90
51_D117_N0.8700.89
147_D151_T0.8670.89
70_V86_G0.8630.89
87_P93_D0.8630.89
101_L105_A0.8600.89
31_D34_D0.8600.89
49_Q53_W0.8500.88
95_T98_Y0.8420.88
144_D149_T0.8420.88
73_G76_E0.8410.88
2_L19_I0.8400.88
164_L168_T0.8330.87
72_F82_G0.8170.86
15_L19_I0.8130.86
141_Y153_Y0.8040.85
35_F49_Q0.7920.84
175_R180_R0.7920.84
32_L35_F0.7850.84
11_N16_V0.7800.84
114_I118_I0.7730.83
47_G61_R0.7690.83
89_Y93_D0.7600.82
14_K18_L0.7580.82
159_L164_L0.7570.82
94_P97_G0.7550.82
32_L36_L0.7540.81
22_L25_P0.7440.81
145_N148_M0.7430.81
135_G139_R0.7400.80
14_K17_A0.7370.80
167_L173_L0.7360.80
19_I23_N0.7360.80
36_L52_I0.7290.79
5_I15_L0.7250.79
154_V160_T0.7220.79
36_L40_F0.7210.78
3_D38_D0.7180.78
99_T105_A0.7170.78
55_R110_I0.7150.78
40_F52_I0.7110.78
149_T182_N0.7080.77
115_A128_A0.7070.77
23_N26_L0.7070.77
7_S15_L0.7040.77
137_G140_A0.7020.77
70_V92_G0.7010.77
3_D16_V0.6930.76
108_L135_G0.6920.76
143_V154_V0.6830.75
48_F51_D0.6760.74
173_L176_P0.6750.74
52_I55_R0.6740.74
5_I30_Q0.6730.74
84_D90_G0.6680.73
172_L175_R0.6660.73
128_A134_F0.6660.73
36_L39_V0.6620.72
72_F87_P0.6600.72
63_L170_S0.6600.72
8_Q12_S0.6590.72
149_T180_R0.6580.72
4_L49_Q0.6580.72
153_Y173_L0.6560.72
89_Y92_G0.6530.71
14_K19_I0.6500.71
12_S16_V0.6500.71
2_L23_N0.6480.71
76_E85_Q0.6410.70
83_F89_Y0.6410.70
10_A16_V0.6350.69
122_T129_I0.6330.69
82_G86_G0.6290.69
85_Q90_G0.6280.68
50_L107_R0.6230.68
123_I153_Y0.6220.68
25_P110_I0.6210.68
48_F115_A0.6190.67
123_I126_I0.6160.67
108_L132_F0.6110.66
17_A20_E0.6110.66
5_I9_Y0.6090.66
127_N131_R0.6090.66
50_L178_G0.6070.66
31_D35_F0.6000.65
126_I130_L0.6000.65
59_V113_K0.5940.64
48_F55_R0.5920.64
24_Q90_G0.5920.64
127_N176_P0.5910.64
170_S173_L0.5910.64
18_L23_N0.5900.64
124_P127_N0.5890.63
111_K114_I0.5880.63
32_L39_V0.5840.63
134_F140_A0.5830.63
116_A126_I0.5820.63
108_L136_G0.5790.62
175_R181_V0.5740.61
76_E90_G0.5700.61
17_A43_D0.5640.60
84_D91_G0.5610.60
116_A171_D0.5610.60
21_A105_A0.5590.59
13_P16_V0.5580.59
104_D128_A0.5550.59
5_I20_E0.5540.59
15_L56_I0.5540.59
4_L45_A0.5530.59
73_G83_F0.5510.58
5_I14_K0.5490.58
155_F163_E0.5490.58
100_S142_V0.5480.58
3_D18_L0.5460.58
130_L141_Y0.5450.58
45_A107_R0.5420.57
46_V53_W0.5420.57
58_G103_D0.5410.57
53_W114_I0.5400.57
134_F163_E0.5390.57
61_R117_N0.5390.57
12_S111_K0.5380.57
2_L30_Q0.5370.56
10_A13_P0.5370.56
72_F75_D0.5340.56
12_S35_F0.5320.56
71_Y89_Y0.5320.56
68_T98_Y0.5320.56
44_T60_S0.5320.56
18_L29_L0.5310.56
24_Q169_Q0.5290.55
51_D101_L0.5280.55
33_L37_D0.5280.55
44_T50_L0.5260.55
164_L167_L0.5260.55
30_Q33_L0.5250.55
81_L85_Q0.5230.54
112_A172_L0.5200.54
3_D10_A0.5180.54
8_Q59_V0.5180.54
121_G125_S0.5170.54
3_D21_A0.5140.53
9_Y56_I0.5140.53
110_I114_I0.5120.53
150_M176_P0.5110.53
131_R137_G0.5100.53
5_I13_P0.5100.53
50_L54_G0.5100.53
34_D37_D0.5080.52
37_D40_F0.5080.52
58_G106_Y0.5070.52
124_P141_Y0.5060.52
124_P128_A0.5060.52
146_G151_T0.5050.52
39_V49_Q0.5030.52
35_F53_W0.5020.52
54_G58_G0.5010.51
155_F166_I0.5000.51
90_G98_Y0.5000.51
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1yx3A 1 0.3333 11.9 0.943 Contact Map
4jpdA 5 0.377 8.3 0.947 Contact Map
1sauA 1 0.3279 7.5 0.948 Contact Map
2j9wA 1 0.2951 6.5 0.949 Contact Map
4w4mA 1 0.3497 5.8 0.95 Contact Map
2g7hA 1 0.541 5.5 0.951 Contact Map
1j5wA 2 0.2842 4.8 0.952 Contact Map
1ew4A 1 0.3661 4.5 0.953 Contact Map
4a18M 1 0.1913 4.3 0.953 Contact Map
4f37A 1 0.3497 4 0.954 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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