GREMLIN Database
DUF2823 - Protein of unknown function (DUF2823)
PFAM: PF11034 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 67 (67)
Sequences: 775 (482)
Seq/√Len: 58.9
META: 0.796

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
23_S51_D2.7071.00
24_K48_A2.6531.00
63_E67_E2.6121.00
23_S27_N2.1751.00
4_I8_A1.8911.00
17_E59_E1.8281.00
13_E61_K1.7960.99
56_K59_E1.7900.99
20_S54_D1.7880.99
16_Q58_H1.7730.99
38_L42_A1.7430.99
42_A46_K1.7170.99
61_K65_H1.7100.99
30_V36_A1.6260.99
13_E58_H1.6000.99
21_G55_E1.3980.97
2_D6_N1.3900.97
20_S58_H1.3820.97
20_S51_D1.3540.96
18_A21_G1.3270.96
13_E65_H1.2990.95
10_Y62_A1.2360.94
63_E66_K1.2150.93
55_E59_E1.1920.92
14_K18_A1.1730.92
46_K49_V1.1660.92
12_S16_Q1.1530.91
14_K17_E1.1360.90
27_N47_D1.1360.90
50_G53_V1.1320.90
15_V18_A1.0770.88
24_K56_K1.0760.88
29_E32_K1.0430.86
17_E21_G1.0250.85
36_A44_A1.0140.85
43_S46_K0.9990.84
24_K55_E0.9830.83
1_M5_K0.9820.83
49_V53_V0.9770.82
10_Y14_K0.9470.80
9_N12_S0.9130.78
31_A41_R0.9020.77
3_T6_N0.9020.77
30_V44_A0.8920.76
17_E55_E0.8880.76
36_A40_T0.8880.76
40_T43_S0.8860.76
37_S40_T0.8720.75
21_G24_K0.8720.75
7_A11_V0.8510.73
42_A45_A0.8380.72
46_K50_G0.8370.72
2_D33_D0.8260.71
45_A50_G0.8180.70
54_D57_K0.8060.69
25_E35_N0.8050.69
53_V57_K0.7640.65
27_N51_D0.7590.64
6_N65_H0.7580.64
60_A63_E0.7570.64
45_A49_V0.7310.61
53_V56_K0.7310.61
7_A10_Y0.7300.61
21_G56_K0.7260.61
2_D5_K0.7230.60
31_A48_A0.7180.60
50_G57_K0.7170.60
24_K28_K0.7040.58
8_A11_V0.7000.58
27_N30_V0.6980.58
57_K61_K0.6970.57
13_E20_S0.6940.57
40_T44_A0.6630.54
59_E67_E0.6620.54
35_N40_T0.6580.53
56_K60_A0.6560.53
10_Y18_A0.6500.52
60_A64_A0.6460.52
30_V40_T0.6340.50
33_D36_A0.6260.50
13_E16_Q0.6250.49
27_N44_A0.6170.49
44_A47_D0.6100.48
47_D67_E0.6000.47
40_T47_D0.5920.46
38_L46_K0.5920.46
11_V22_A0.5890.45
5_K8_A0.5800.44
23_S32_K0.5630.43
51_D54_D0.5600.42
43_S47_D0.5530.42
27_N31_A0.5410.40
25_E28_K0.5320.39
23_S26_A0.5320.39
2_D38_L0.5290.39
17_E62_A0.5170.38
47_D50_G0.5170.38
22_A26_A0.5140.37
30_V33_D0.5130.37
6_N9_N0.5000.36
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1iojA 1 0.7164 5.7 0.889 Contact Map
2l9qA 1 0.5224 3.6 0.9 Contact Map
2kfeA 1 0.2687 3.6 0.9 Contact Map
1pehA 1 0.3433 2.9 0.904 Contact Map
1l8wA 2 0.6866 2.6 0.907 Contact Map
2yk0A 1 0.4328 2.1 0.911 Contact Map
4po2A 4 0.6716 1.8 0.914 Contact Map
2wqdA 2 1 1.7 0.915 Contact Map
4f01A 2 0.6418 1.7 0.916 Contact Map
2nnuA 1 0.4478 1.7 0.916 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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