GREMLIN Database
DUF2721 - Protein of unknown function (DUF2721)
PFAM: PF11026 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 129 (127)
Sequences: 12532 (8230)
Seq/√Len: 730.3
META: 0.935

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
70_G112_S4.2971.00
69_L111_A3.4221.00
24_R27_D3.0231.00
9_S13_L2.9261.00
16_L20_N2.7711.00
68_T117_L2.7431.00
34_A38_A2.4901.00
75_L110_I2.3061.00
65_R115_L2.2951.00
25_I63_I2.2521.00
31_A34_A2.1851.00
78_V110_I2.1761.00
72_L108_L2.1041.00
31_A35_E2.0811.00
62_L115_L2.0341.00
9_S16_L1.7821.00
18_L66_A1.7801.00
13_L16_L1.7701.00
118_R121_R1.7131.00
83_L101_L1.6871.00
114_V118_R1.6261.00
73_S109_L1.6181.00
77_F105_A1.6171.00
98_A102_F1.5881.00
11_I73_S1.5661.00
58_R122_L1.5511.00
61_R65_R1.4621.00
36_L50_L1.4541.00
76_L108_L1.4481.00
25_I56_L1.3881.00
111_A115_L1.3541.00
11_I74_A1.3341.00
68_T120_I1.3321.00
28_R31_A1.3091.00
23_A27_D1.3041.00
32_L49_L1.2881.00
62_L118_R1.2801.00
57_R128_R1.2801.00
26_V30_R1.2491.00
71_V117_L1.2421.00
75_L114_V1.1961.00
71_V113_L1.1881.00
68_T121_R1.1731.00
50_L54_R1.1571.00
100_V104_L1.1531.00
71_V116_F1.1431.00
115_L118_R1.1391.00
18_L112_S1.1141.00
125_R128_R1.1051.00
25_I60_A1.1041.00
40_P43_E1.0991.00
65_R68_T1.0981.00
29_I53_L1.0871.00
87_G94_L1.0661.00
80_T98_A1.0591.00
76_L101_L1.0591.00
35_E38_A1.0491.00
18_L70_G1.0371.00
99_A102_F1.0341.00
39_L49_L1.0181.00
83_L97_L1.0161.00
80_T101_L1.0121.00
57_R60_A1.0121.00
96_W100_V0.9931.00
107_L111_A0.9721.00
123_A126_A0.9721.00
61_R128_R0.9701.00
93_D96_W0.9591.00
55_N126_A0.9561.00
41_E45_R0.9291.00
103_I106_L0.9261.00
33_E37_E0.9041.00
58_R62_L0.8991.00
41_E46_R0.8961.00
74_A113_L0.8871.00
34_A37_E0.8841.00
17_V71_V0.8801.00
69_L108_L0.8771.00
85_F103_I0.8761.00
19_T23_A0.8631.00
118_R122_L0.8611.00
48_R52_Q0.8591.00
6_F11_I0.8511.00
121_R125_R0.8461.00
13_L17_V0.8451.00
14_L18_L0.8441.00
5_A10_A0.8421.00
2_V5_A0.8351.00
26_V29_I0.8301.00
78_V109_L0.8301.00
51_A54_R0.8291.00
58_R61_R0.8221.00
12_G16_L0.8051.00
58_R118_R0.8041.00
80_T84_L0.8041.00
14_L109_L0.7971.00
96_W99_A0.7951.00
35_E49_L0.7931.00
55_N58_R0.7911.00
99_A103_I0.7831.00
124_T128_R0.7821.00
14_L74_A0.7781.00
42_D46_R0.7751.00
109_L113_L0.7721.00
27_D31_A0.7711.00
48_R51_A0.7661.00
2_V6_F0.7631.00
29_I33_E0.7601.00
57_R61_R0.7451.00
93_D99_A0.7411.00
124_T127_L0.7401.00
47_E51_A0.7371.00
54_R58_R0.7331.00
41_E44_E0.7301.00
82_L103_I0.7291.00
82_L110_I0.7231.00
44_E47_E0.7121.00
42_D45_R0.7101.00
39_L47_E0.7081.00
47_E50_L0.7081.00
46_R50_L0.6961.00
5_A9_S0.6921.00
37_E43_E0.6901.00
46_R52_Q0.6901.00
40_P45_R0.6891.00
76_L104_L0.6871.00
21_R119_E0.6871.00
81_I106_L0.6861.00
118_R125_R0.6821.00
15_L67_I0.6671.00
8_L74_A0.6661.00
8_L12_G0.6651.00
75_L113_L0.6631.00
77_F80_T0.6621.00
10_A74_A0.6611.00
97_L100_V0.6571.00
39_L44_E0.6481.00
5_A81_I0.6441.00
3_A6_F0.6401.00
3_A77_F0.6391.00
73_S77_F0.6381.00
113_L116_F0.6341.00
32_L56_L0.6291.00
14_L70_G0.6291.00
6_F13_L0.6271.00
69_L115_L0.6251.00
15_L70_G0.6211.00
59_R119_E0.6141.00
33_E53_L0.6121.00
23_A26_V0.6091.00
38_A43_E0.6041.00
84_L88_A0.5991.00
37_E40_P0.5981.00
83_L98_A0.5971.00
2_V9_S0.5951.00
39_L42_D0.5951.00
17_V116_F0.5911.00
44_E50_L0.5881.00
110_I114_V0.5881.00
16_L19_T0.5791.00
95_A99_A0.5781.00
94_L97_L0.5781.00
2_V15_L0.5741.00
6_F81_I0.5701.00
64_R68_T0.5701.00
97_L101_L0.5681.00
76_L105_A0.5661.00
20_N23_A0.5641.00
9_S12_G0.5541.00
87_G91_G0.5541.00
64_R124_T0.5491.00
41_E47_E0.5421.00
39_L43_E0.5381.00
62_L122_L0.5371.00
77_F81_I0.5361.00
49_L52_Q0.5351.00
79_L101_L0.5321.00
69_L112_S0.5321.00
18_L67_I0.5301.00
72_L117_L0.5281.00
84_L98_A0.5241.00
33_E36_L0.5231.00
3_A9_S0.5211.00
46_R49_L0.5161.00
42_D47_E0.5151.00
45_R50_L0.5131.00
22_L123_A0.5121.00
88_A91_G0.5121.00
64_R74_A0.5000.99
65_R121_R0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3pjsK 4 0.5039 28.6 0.876 Contact Map
3effK 4 0.5039 19.9 0.884 Contact Map
3rvyA 3 0.1705 9.5 0.9 Contact Map
3vouA 4 0.4419 7.2 0.905 Contact Map
4h33A 3 0.2093 7 0.906 Contact Map
3d9sA 3 0.2946 6.3 0.908 Contact Map
3b5xA 2 0.9845 6.1 0.909 Contact Map
4ry2A 2 0.9845 5.7 0.91 Contact Map
4bgnA 3 0.2713 5.5 0.91 Contact Map
3b60A 2 0.9922 5.2 0.912 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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