GREMLIN Database
DUF2852 - Protein of unknown function (DUF2852)
PFAM: PF11014 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 122 (120)
Sequences: 3802 (2477)
Seq/√Len: 226.1
META: 0.918

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
112_A116_Q3.7931.00
89_R93_E2.5711.00
111_K115_D2.3961.00
13_M31_I2.3771.00
78_R107_R2.3341.00
96_R100_E2.2831.00
104_R120_E2.0891.00
13_M27_L2.0041.00
55_F58_M1.9491.00
84_R108_A1.9341.00
107_R111_K1.8581.00
55_F59_R1.8451.00
34_S37_M1.8021.00
47_W51_M1.7981.00
103_E107_R1.7781.00
86_E89_R1.7081.00
59_R62_R1.7081.00
75_S95_Q1.7051.00
2_D5_G1.6411.00
26_A29_A1.6301.00
16_G23_L1.6281.00
48_Q52_E1.6241.00
92_E102_L1.5611.00
48_Q51_M1.5231.00
93_E97_E1.4971.00
99_R103_E1.4681.00
54_M58_M1.4561.00
107_R112_A1.4141.00
10_I14_V1.4111.00
50_K54_M1.3821.00
5_G8_A1.3651.00
45_G49_R1.3581.00
54_M57_K1.3481.00
78_R82_E1.3441.00
7_P11_A1.3401.00
51_M55_F1.2821.00
116_Q120_E1.2781.00
16_G20_F1.2651.00
66_G69_G1.2531.00
53_R59_R1.2451.00
30_Y34_S1.2421.00
69_G72_P1.2331.00
44_R48_Q1.2301.00
90_R94_E1.2301.00
29_A33_W1.2271.00
13_M16_G1.2171.00
57_K61_M1.1901.00
33_W37_M1.1901.00
44_R49_R1.1881.00
67_G70_G1.1861.00
46_R50_K1.1731.00
57_K62_R1.1651.00
43_G47_W1.1501.00
101_F109_K1.1331.00
5_G9_W1.1191.00
58_M61_M1.1101.00
2_D6_K1.1031.00
114_F118_M1.0791.00
84_R105_L1.0791.00
60_R63_G1.0771.00
26_A30_Y1.0701.00
21_W25_L1.0421.00
99_R107_R1.0241.00
55_F61_M1.0231.00
68_G71_G1.0171.00
85_A89_R1.0161.00
29_A32_I1.0001.00
42_G49_R0.9841.00
89_R92_E0.9801.00
45_G48_Q0.9761.00
47_W50_K0.9661.00
76_G81_D0.9591.00
15_L19_V0.9571.00
49_R53_R0.9561.00
57_K60_R0.9451.00
46_R49_R0.9421.00
23_L27_L0.9371.00
13_M17_F0.9351.00
52_E55_F0.9251.00
43_G46_R0.9221.00
82_E107_R0.9130.99
51_M54_M0.9110.99
49_R54_M0.9100.99
50_K53_R0.8990.99
28_L32_I0.8860.99
46_R51_M0.8790.99
83_Y87_T0.8770.99
19_V23_L0.8760.99
55_F62_R0.8750.99
98_F101_F0.8590.99
64_R67_G0.8430.99
17_F28_L0.8330.99
26_A33_W0.8250.99
100_E103_E0.8180.99
45_G51_M0.8090.99
70_G73_R0.8070.99
46_R52_E0.7980.99
87_T95_Q0.7890.99
50_K55_F0.7870.98
56_S61_M0.7820.98
95_Q99_R0.7770.98
2_D9_W0.7750.98
20_F27_L0.7730.98
105_L108_A0.7570.98
52_E56_S0.7540.98
19_V27_L0.7510.98
53_R58_M0.7500.98
4_R7_P0.7450.98
92_E96_R0.7440.98
13_M18_I0.7370.98
54_M59_R0.7330.98
95_Q104_R0.7320.98
116_Q119_A0.7310.98
105_L109_K0.7300.98
93_E96_R0.7240.97
54_M61_M0.7230.97
102_L105_L0.7160.97
9_W31_I0.7160.97
65_G69_G0.7100.97
75_S81_D0.7090.97
66_G70_G0.7080.97
4_R12_L0.7060.97
56_S59_R0.7060.97
83_Y101_F0.7060.97
42_G46_R0.6960.97
17_F24_G0.6960.97
20_F23_L0.6940.97
34_S39_C0.6850.96
49_R55_F0.6770.96
12_L27_L0.6720.96
59_R63_G0.6660.96
104_R107_R0.6640.96
39_C42_G0.6580.95
14_V17_F0.6570.95
42_G45_G0.6530.95
111_K119_A0.6520.95
9_W12_L0.6510.95
56_S60_R0.6470.95
68_G73_R0.6460.95
32_I37_M0.6420.95
74_S81_D0.6400.95
16_G31_I0.6380.95
50_K58_M0.6280.94
5_G36_R0.6280.94
65_G68_G0.6250.94
53_R61_M0.6240.94
9_W13_M0.6160.94
57_K63_G0.6150.94
108_A117_F0.6100.93
20_F24_G0.6050.93
93_E117_F0.6020.93
53_R57_K0.6000.93
88_L92_E0.6000.93
27_L35_G0.5800.91
20_F31_I0.5800.91
51_M57_K0.5720.91
43_G51_M0.5710.91
62_R65_G0.5710.91
16_G27_L0.5710.91
27_L31_I0.5650.90
45_G50_K0.5620.90
3_E9_W0.5600.90
92_E105_L0.5590.90
11_A19_V0.5560.90
44_R52_E0.5550.90
43_G49_R0.5470.89
3_E7_P0.5370.88
82_E86_E0.5360.88
53_R56_S0.5320.88
88_L91_L0.5270.87
8_A11_A0.5250.87
107_R118_M0.5250.87
12_L68_G0.5240.87
58_M62_R0.5090.85
47_W52_E0.5080.85
51_M58_M0.5060.85
4_R9_W0.5020.84
30_Y33_W0.5010.84
97_E100_E0.5000.84
5_G30_Y0.5000.84
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1cd1A 1 0.041 11.5 0.936 Contact Map
1o5hA 2 0.5984 9.9 0.937 Contact Map
1s7qA 1 0.0574 9.4 0.938 Contact Map
2l9uA 2 0.3279 6.2 0.943 Contact Map
1m8oB 1 0.1639 5.5 0.944 Contact Map
1ciiA 1 0.418 5 0.946 Contact Map
2k1kA 2 0.2869 5 0.946 Contact Map
3mk7A 1 0.3689 4.8 0.946 Contact Map
4um9B 2 0 4.8 0.946 Contact Map
2kncB 1 0.6148 4.7 0.946 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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